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Breast tomosynthesis and digital mammography: a comparison of diagnostic accuracy.

Svahn, Tony LU ; Chakraborty, D P; Ikeda, D; Zackrisson, Sophia LU ; Do, Y; Mattsson, Sören LU and Andersson, Ingvar LU (2012) In British Journal of Radiology
Abstract
Objective:

Our aim was to compare the ability of radiologists to detect breast cancers using one-view breast tomosynthesis (BT) and two-view digital mammography (DM) in an enriched population of abnormal (diseased) patients and benign and/or normal (healthy) patients.



Methods:

All participants gave informed consent. The BT and DM examinations were performed with about the same average glandular dose to the breast. The study population comprised patients with subtle signs of malignancy seen on DM and/or ultrasonography. Ground truth was established by pathology, needle biopsy and/or by 1-year follow-up by mammography, which retrospectively resulted in 89 abnormal breasts (one breast per patient) with... (More)
Objective:

Our aim was to compare the ability of radiologists to detect breast cancers using one-view breast tomosynthesis (BT) and two-view digital mammography (DM) in an enriched population of abnormal (diseased) patients and benign and/or normal (healthy) patients.



Methods:

All participants gave informed consent. The BT and DM examinations were performed with about the same average glandular dose to the breast. The study population comprised patients with subtle signs of malignancy seen on DM and/or ultrasonography. Ground truth was established by pathology, needle biopsy and/or by 1-year follow-up by mammography, which retrospectively resulted in 89 abnormal breasts (one breast per patient) with 95 malignant lesions and 96 normal or benign breasts. Two experienced radiologists, non-participants in the study, determined the locations of the malignant lesions. Five radiologists, experienced in mammography, interpreted the cases independently in a free-response study. The data were analysed by the receiver operating characteristic (ROC) and jackknife alternative free-response ROC (JAFROC) methods, regarding both readers and cases as random effects.



Results:

The diagnostic accuracy of BT was significantly better than that of DM (JAFROC: p = 0.0031, ROC: p = 0.0415). The average sensitivity of BT was higher than that for DM (∼90 vs ∼79%; 95% confidence interval of difference: [0.036, 0.108]) while the average false positive fraction was not significantly different (95% confidence interval of difference: [-0.117, 0.010]).Conclusion: The diagnostic accuracy of BT was superior to DM in an enriched population. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
British Journal of Radiology
publisher
British Inst Radiology
external identifiers
  • WOS:000311603400016
  • PMID:22674710
  • Scopus:84864849066
ISSN
1748-880X
DOI
10.1259/bjr/53282892
language
English
LU publication?
yes
id
afda534b-b200-4bb5-8a18-ac7f5b79ca3c (old id 2859722)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/22674710?dopt=Abstract
date added to LUP
2012-07-04 11:30:35
date last changed
2016-11-13 04:28:39
@misc{afda534b-b200-4bb5-8a18-ac7f5b79ca3c,
  abstract     = {Objective: <br/><br>
Our aim was to compare the ability of radiologists to detect breast cancers using one-view breast tomosynthesis (BT) and two-view digital mammography (DM) in an enriched population of abnormal (diseased) patients and benign and/or normal (healthy) patients.<br/><br>
<br/><br>
Methods: <br/><br>
All participants gave informed consent. The BT and DM examinations were performed with about the same average glandular dose to the breast. The study population comprised patients with subtle signs of malignancy seen on DM and/or ultrasonography. Ground truth was established by pathology, needle biopsy and/or by 1-year follow-up by mammography, which retrospectively resulted in 89 abnormal breasts (one breast per patient) with 95 malignant lesions and 96 normal or benign breasts. Two experienced radiologists, non-participants in the study, determined the locations of the malignant lesions. Five radiologists, experienced in mammography, interpreted the cases independently in a free-response study. The data were analysed by the receiver operating characteristic (ROC) and jackknife alternative free-response ROC (JAFROC) methods, regarding both readers and cases as random effects.<br/><br>
<br/><br>
Results: <br/><br>
The diagnostic accuracy of BT was significantly better than that of DM (JAFROC: p = 0.0031, ROC: p = 0.0415). The average sensitivity of BT was higher than that for DM (∼90 vs ∼79%; 95% confidence interval of difference: [0.036, 0.108]) while the average false positive fraction was not significantly different (95% confidence interval of difference: [-0.117, 0.010]).Conclusion: The diagnostic accuracy of BT was superior to DM in an enriched population.},
  author       = {Svahn, Tony and Chakraborty, D P and Ikeda, D and Zackrisson, Sophia and Do, Y and Mattsson, Sören and Andersson, Ingvar},
  issn         = {1748-880X},
  language     = {eng},
  month        = {06},
  publisher    = {ARRAY(0x82e0f28)},
  series       = {British Journal of Radiology},
  title        = {Breast tomosynthesis and digital mammography: a comparison of diagnostic accuracy.},
  url          = {http://dx.doi.org/10.1259/bjr/53282892},
  year         = {2012},
}