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Telomere length in blood and skeletal muscle in relation to measures of glycaemia and insulinaemia.

Ahmad, Shafqat LU ; Heraclides, A; Sun, Q; Elgzyri, Targ LU ; Rönn, Tina LU ; Ling, Charlotte LU ; Isomaa, B; Eriksson, Karl-Fredrik LU ; Groop, Leif LU and Franks, Paul LU , et al. (2012) In Diabetic medicine : a journal of the British Diabetic Association 29(10). p.377-381
Abstract
Aims:

Skeletal muscle is a major metabolic organ and plays important roles in glucose metabolism, insulin sensitivity and insulin action. Muscle telomere length reflects the myocyte's exposure to harmful environmental factors. Leukocyte telomere length is considered a marker of muscle telomere length and is used in epidemiologic studies to assess associations with ageing-related diseases where muscle physiology is important. However, the extent to which leucocyte and muscle telomere length are correlated is unknown, as are their relative correlations with glucose and insulin concentrations. The purpose of this study was to determine the extent of these relationships.



Methods:

Leucocyte and muscle... (More)
Aims:

Skeletal muscle is a major metabolic organ and plays important roles in glucose metabolism, insulin sensitivity and insulin action. Muscle telomere length reflects the myocyte's exposure to harmful environmental factors. Leukocyte telomere length is considered a marker of muscle telomere length and is used in epidemiologic studies to assess associations with ageing-related diseases where muscle physiology is important. However, the extent to which leucocyte and muscle telomere length are correlated is unknown, as are their relative correlations with glucose and insulin concentrations. The purpose of this study was to determine the extent of these relationships.



Methods:

Leucocyte and muscle telomere length were measured by quantitative real-time polymerase chain reaction in participants from the Malmö Exercise Intervention (n = 27) and the Prevalence, Prediction and Prevention of Diabetes-Botnia studies (n = 31). Participants in both studies were free from Type 2 diabetes. We assessed the association between leucocyte telomere length, muscle telomere length and metabolic traits using Spearmen correlations and multivariate linear regression. Bland-Altman analysis was used to assess agreement between leucocyte and muscle telomere length.



Results:

In age-, study-, diabetes family history- and sex-adjusted models, leucocyte and muscle telomere length were positively correlated (r = 0.39, 95% CI 0.15-0.59). Leucocyte telomere length was inversely associated with 2-h glucose concentrations (r = -0.58, 95% CI -1.0 to -0.16), but there was no correlation between muscle telomere length and 2-h glucose concentrations (r = 0.05, 95% CI -0.35 to 0.46) or between leucocyte or muscle telomere length with other metabolic traits.



Conclusions:

In summary, the current study supports the use of leucocyte telomere length as a proxy for muscle telomere length in epidemiological studies of Type 2 diabetes aetiology. (Less)
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organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Diabetic medicine : a journal of the British Diabetic Association
volume
29
issue
10
pages
377 - 381
publisher
Wiley-Blackwell
external identifiers
  • WOS:000308960400004
  • PMID:22747879
  • Scopus:84866451388
ISSN
1464-5491
DOI
10.1111/j.1464-5491.2012.03737.x
language
English
LU publication?
yes
id
7ffef861-54fb-4f94-a83b-28033c1325d0 (old id 2967661)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/22747879?dopt=Abstract
date added to LUP
2012-08-09 14:46:54
date last changed
2016-12-04 04:40:15
@misc{7ffef861-54fb-4f94-a83b-28033c1325d0,
  abstract     = {Aims:<br/><br>
Skeletal muscle is a major metabolic organ and plays important roles in glucose metabolism, insulin sensitivity and insulin action. Muscle telomere length reflects the myocyte's exposure to harmful environmental factors. Leukocyte telomere length is considered a marker of muscle telomere length and is used in epidemiologic studies to assess associations with ageing-related diseases where muscle physiology is important. However, the extent to which leucocyte and muscle telomere length are correlated is unknown, as are their relative correlations with glucose and insulin concentrations. The purpose of this study was to determine the extent of these relationships. <br/><br>
<br/><br>
Methods:<br/><br>
Leucocyte and muscle telomere length were measured by quantitative real-time polymerase chain reaction in participants from the Malmö Exercise Intervention (n = 27) and the Prevalence, Prediction and Prevention of Diabetes-Botnia studies (n = 31). Participants in both studies were free from Type 2 diabetes. We assessed the association between leucocyte telomere length, muscle telomere length and metabolic traits using Spearmen correlations and multivariate linear regression. Bland-Altman analysis was used to assess agreement between leucocyte and muscle telomere length. <br/><br>
<br/><br>
Results:<br/><br>
In age-, study-, diabetes family history- and sex-adjusted models, leucocyte and muscle telomere length were positively correlated (r = 0.39, 95% CI 0.15-0.59). Leucocyte telomere length was inversely associated with 2-h glucose concentrations (r = -0.58, 95% CI -1.0 to -0.16), but there was no correlation between muscle telomere length and 2-h glucose concentrations (r = 0.05, 95% CI -0.35 to 0.46) or between leucocyte or muscle telomere length with other metabolic traits. <br/><br>
<br/><br>
Conclusions:<br/><br>
In summary, the current study supports the use of leucocyte telomere length as a proxy for muscle telomere length in epidemiological studies of Type 2 diabetes aetiology.},
  author       = {Ahmad, Shafqat and Heraclides, A and Sun, Q and Elgzyri, Targ and Rönn, Tina and Ling, Charlotte and Isomaa, B and Eriksson, Karl-Fredrik and Groop, Leif and Franks, Paul and Hansson, Ola},
  issn         = {1464-5491},
  language     = {eng},
  number       = {10},
  pages        = {377--381},
  publisher    = {ARRAY(0x975f260)},
  series       = {Diabetic medicine : a journal of the British Diabetic Association},
  title        = {Telomere length in blood and skeletal muscle in relation to measures of glycaemia and insulinaemia.},
  url          = {http://dx.doi.org/10.1111/j.1464-5491.2012.03737.x},
  volume       = {29},
  year         = {2012},
}