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Detection of tumor necrosis factor alpha but not tumor necrosis factor beta in rheumatoid arthritis synovial fluid and serum.

Saxne, Tore LU ; Palladino, Michael ; Heinegård, Dick LU ; Talal, Norman and Wollheim, Frank LU (1988) In Arthritis and Rheumatism 31(8). p.1041-1045
Abstract
Synovial fluids from 6 of 12 patients with rheumatoid arthritis (RA) and from 3 of 11 patients with reactive arthritis contained measurable levels of tumor necrosis factor α (TNFα). Seven of 12 sera from RA patients contained TNFα, while only 1 of those from reactive arthritis patients was positive. Gamma-interferon was detected in the synovial fluids and sera of only the RA patients. Tumor necrosis factor β was not detected in any sera or synovial fluids. RA patients with detectable TNFα had higher erythrocyte sedimentation rates and synovial fluid leukocyte counts.
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author
; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
in
Arthritis and Rheumatism
volume
31
issue
8
pages
1041 - 1045
publisher
John Wiley & Sons Inc.
external identifiers
  • scopus:0023712236
ISSN
0004-3591
language
English
LU publication?
yes
id
2cb0f821-d861-4ad3-a2c0-cea40268079a
date added to LUP
2016-05-06 16:02:37
date last changed
2021-03-21 05:26:46
@article{2cb0f821-d861-4ad3-a2c0-cea40268079a,
  abstract     = {{Synovial fluids from 6 of 12 patients with rheumatoid arthritis (RA) and from 3 of 11 patients with reactive arthritis contained measurable levels of tumor necrosis factor α (TNFα). Seven of 12 sera from RA patients contained TNFα, while only 1 of those from reactive arthritis patients was positive. Gamma-interferon was detected in the synovial fluids and sera of only the RA patients. Tumor necrosis factor β was not detected in any sera or synovial fluids. RA patients with detectable TNFα had higher erythrocyte sedimentation rates and synovial fluid leukocyte counts.}},
  author       = {{Saxne, Tore and Palladino, Michael and Heinegård, Dick and Talal, Norman and Wollheim, Frank}},
  issn         = {{0004-3591}},
  language     = {{eng}},
  number       = {{8}},
  pages        = {{1041--1045}},
  publisher    = {{John Wiley & Sons Inc.}},
  series       = {{Arthritis and Rheumatism}},
  title        = {{Detection of tumor necrosis factor alpha but not tumor necrosis factor beta in rheumatoid arthritis synovial fluid and serum.}},
  volume       = {{31}},
  year         = {{1988}},
}