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Factors related to the progression of joint destruction in rheumatoid arthritis.

Sjöblom, K G; Saxne, Tore LU ; Petersson, H and Wollheim, Frank LU (1984) In Scandinavian Journal of Rheumatology 13(1). p.21-27
Abstract
In 103 (M=25, F=78) of 150 consecutive RA patients, values of the following variables were obtained at the start and end of a 2-year follow-up period: radiographic destruction score of hands and feet according to Larsen (Larsen index), Ritchie index, B-hemoglobin, ESR and plasma proteins (α1-antitrypsin, ceruloplasmin, CRP, fibrinogen, haptoglobin, orosomucoid, IgA, IgG, IgM, C3 and C4). 60% of the values of ΔLI (final minus initial value of Larsen index) were significantly larger than zero (11-44 units, p<0.05). ΔLI was larger in females than in males (p=0.11). Comparing women with duration of disease (DoD) 1-6 years versus 7-52 years, ΔLI was larger in the former group (p=0.005). Comparing women with the largest ΔLI (19-44 units) with... (More)
In 103 (M=25, F=78) of 150 consecutive RA patients, values of the following variables were obtained at the start and end of a 2-year follow-up period: radiographic destruction score of hands and feet according to Larsen (Larsen index), Ritchie index, B-hemoglobin, ESR and plasma proteins (α1-antitrypsin, ceruloplasmin, CRP, fibrinogen, haptoglobin, orosomucoid, IgA, IgG, IgM, C3 and C4). 60% of the values of ΔLI (final minus initial value of Larsen index) were significantly larger than zero (11-44 units, p<0.05). ΔLI was larger in females than in males (p=0.11). Comparing women with duration of disease (DoD) 1-6 years versus 7-52 years, ΔLI was larger in the former group (p=0.005). Comparing women with the largest ΔLI (19-44 units) with the remainder ones (ΔLI=-9-18 units), CRP and haptoglobin was higher and IgM lower in the former group (p=0.03, 0.02 and 0.03 respectively). In women with DoD 1-6 years (and only in this interval) significant linear relationships were found between ALI and hemoglobin (r-0.52, p<0.01) Ritchie index, haptoglobin, CRP (r=0.41-0.46, p<0.05) and IgM (r=-0.43, p<0.05). The mean of repeated hemoglobin values correlated even more strongly with ΔLI (r=0.70, p<0.001). ΔLI was predicted quite well by an expression linear in hemoglobin, fibrinogen and IgM (R=0.84). Similar results were obtained when male patients were included. © 1984 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
rheumatoid arthritis, joint disorders
in
Scandinavian Journal of Rheumatology
volume
13
issue
1
pages
21 - 27
publisher
Taylor & Francis
external identifiers
  • Scopus:0021339756
ISSN
1502-7732
language
English
LU publication?
yes
id
2e849bac-23a0-4fa3-b3d5-666c1b57508e
date added to LUP
2016-05-06 15:42:16
date last changed
2016-11-15 13:29:42
@misc{2e849bac-23a0-4fa3-b3d5-666c1b57508e,
  abstract     = {In 103 (M=25, F=78) of 150 consecutive RA patients, values of the following variables were obtained at the start and end of a 2-year follow-up period: radiographic destruction score of hands and feet according to Larsen (Larsen index), Ritchie index, B-hemoglobin, ESR and plasma proteins (α1-antitrypsin, ceruloplasmin, CRP, fibrinogen, haptoglobin, orosomucoid, IgA, IgG, IgM, C3 and C4). 60% of the values of ΔLI (final minus initial value of Larsen index) were significantly larger than zero (11-44 units, p&lt;0.05). ΔLI was larger in females than in males (p=0.11). Comparing women with duration of disease (DoD) 1-6 years versus 7-52 years, ΔLI was larger in the former group (p=0.005). Comparing women with the largest ΔLI (19-44 units) with the remainder ones (ΔLI=-9-18 units), CRP and haptoglobin was higher and IgM lower in the former group (p=0.03, 0.02 and 0.03 respectively). In women with DoD 1-6 years (and only in this interval) significant linear relationships were found between ALI and hemoglobin (r-0.52, p&lt;0.01) Ritchie index, haptoglobin, CRP (r=0.41-0.46, p&lt;0.05) and IgM (r=-0.43, p&lt;0.05). The mean of repeated hemoglobin values correlated even more strongly with ΔLI (r=0.70, p&lt;0.001). ΔLI was predicted quite well by an expression linear in hemoglobin, fibrinogen and IgM (R=0.84). Similar results were obtained when male patients were included. © 1984 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted},
  author       = {Sjöblom, K G and Saxne, Tore and Petersson, H and Wollheim, Frank},
  issn         = {1502-7732},
  keyword      = {rheumatoid arthritis,joint disorders},
  language     = {eng},
  number       = {1},
  pages        = {21--27},
  publisher    = {ARRAY(0x8003ce8)},
  series       = {Scandinavian Journal of Rheumatology},
  title        = {Factors related to the progression of joint destruction in rheumatoid arthritis.},
  volume       = {13},
  year         = {1984},
}