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Increased release of bone sialoprotein into synovial fluid reflects tissue destruction in rheumatoid arthritis

Saxne, Tore LU ; Zunino, Lelis and Heinegård, Dick LU (1995) In Arthritis and Rheumatism 38(1). p.82-90
Abstract
Objective. Bone sialoprotein (BSP) was quantified in synovial fluids and sera from rheumatoid arthritis (RA) patients to elucidate whether its release from bone relates to the degree of joint tissue destruction. Osteocalcin was assayed for comparison.


Methods. BSP and osteocalcin levels were determined by immunoassays of knee synovial fluids and of sera from RA patients who were selected on the basis of radiographic knee joint tissue damage.


Results. Synovial fluid concentrations of BSP increased with increasing degrees of knee joint damage (rs = 0.6848, P < 0.001). Synovial fluid concentrations of osteocalcin did not relate to the degree of joint damage. Serum concentrations of BSP were increased, but did... (More)
Objective. Bone sialoprotein (BSP) was quantified in synovial fluids and sera from rheumatoid arthritis (RA) patients to elucidate whether its release from bone relates to the degree of joint tissue destruction. Osteocalcin was assayed for comparison.


Methods. BSP and osteocalcin levels were determined by immunoassays of knee synovial fluids and of sera from RA patients who were selected on the basis of radiographic knee joint tissue damage.


Results. Synovial fluid concentrations of BSP increased with increasing degrees of knee joint damage (rs = 0.6848, P < 0.001). Synovial fluid concentrations of osteocalcin did not relate to the degree of joint damage. Serum concentrations of BSP were increased, but did not relate to the degree of joint damage. Serum concentrations of osteocalcin were normal, but increased within the range of normal during progression of joint destruction (rs = 0.4567, P < 0.001).


Conclusion. Quantification of BSP in synovial fluid holds promise as a useful means of assessing the degree of tissue damage at the molecular level in patients with RA. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
bone sialoprotein, rheumatoid arthritis, joint tissue destruction
in
Arthritis and Rheumatism
volume
38
issue
1
pages
82 - 90
publisher
John Wiley & Sons
external identifiers
  • Scopus:0028797761
ISSN
1529-0131
language
English
LU publication?
yes
id
2ef5f4b2-972b-4c9f-9cba-1d0457037b03
date added to LUP
2016-05-07 10:10:19
date last changed
2016-05-26 14:21:23
@misc{2ef5f4b2-972b-4c9f-9cba-1d0457037b03,
  abstract     = {Objective. Bone sialoprotein (BSP) was quantified in synovial fluids and sera from rheumatoid arthritis (RA) patients to elucidate whether its release from bone relates to the degree of joint tissue destruction. Osteocalcin was assayed for comparison.<br>
<br>
<br>
Methods. BSP and osteocalcin levels were determined by immunoassays of knee synovial fluids and of sera from RA patients who were selected on the basis of radiographic knee joint tissue damage.<br>
<br>
<br>
Results. Synovial fluid concentrations of BSP increased with increasing degrees of knee joint damage (rs = 0.6848, P &lt; 0.001). Synovial fluid concentrations of osteocalcin did not relate to the degree of joint damage. Serum concentrations of BSP were increased, but did not relate to the degree of joint damage. Serum concentrations of osteocalcin were normal, but increased within the range of normal during progression of joint destruction (rs = 0.4567, P &lt; 0.001).<br>
<br>
<br>
Conclusion. Quantification of BSP in synovial fluid holds promise as a useful means of assessing the degree of tissue damage at the molecular level in patients with RA.},
  author       = {Saxne, Tore and Zunino, Lelis and Heinegård, Dick},
  issn         = {1529-0131},
  keyword      = {bone sialoprotein,rheumatoid arthritis,joint tissue destruction},
  language     = {eng},
  number       = {1},
  pages        = {82--90},
  publisher    = {ARRAY(0xa58c4b8)},
  series       = {Arthritis and Rheumatism},
  title        = {Increased release of bone sialoprotein into synovial fluid reflects tissue destruction in rheumatoid arthritis},
  volume       = {38},
  year         = {1995},
}