Advanced

MIRD Pamphlet No. 23: Quantitative SPECT for Patient-Specific 3-Dimensional Dosimetry in Internal Radionuclide Therapy

Dewaraja, Y. K.; Frey, E. C.; Sgouros, G.; Brill, A. B.; Roberson, P.; Zanzonico, P. B. and Ljungberg, Michael LU (2012) In Journal of Nuclear Medicine 53(8). p.1310-1325
Abstract
In internal radionuclide therapy, a growing interest in voxel-level estimates of tissue-absorbed dose has been driven by the desire to report radiobiologic quantities that account for the biologic consequences of both spatial and temporal nonuniformities in these dose estimates. This report presents an overview of 3-dimensional SPECT methods and requirements for internal dosimetry at both regional and voxel levels. Combined SPECT/CT image-based methods are emphasized, because the CT-derived anatomic information allows one to address multiple technical factors that affect SPECT quantification while facilitating the patient-specific voxel-level dosimetry calculation itself. SPECT imaging and reconstruction techniques for quantification in... (More)
In internal radionuclide therapy, a growing interest in voxel-level estimates of tissue-absorbed dose has been driven by the desire to report radiobiologic quantities that account for the biologic consequences of both spatial and temporal nonuniformities in these dose estimates. This report presents an overview of 3-dimensional SPECT methods and requirements for internal dosimetry at both regional and voxel levels. Combined SPECT/CT image-based methods are emphasized, because the CT-derived anatomic information allows one to address multiple technical factors that affect SPECT quantification while facilitating the patient-specific voxel-level dosimetry calculation itself. SPECT imaging and reconstruction techniques for quantification in radionuclide therapy are not necessarily the same as those designed to optimize diagnostic imaging quality. The current overview is intended as an introduction to an upcoming series of MIRD pamphlets with detailed radionuclide-specific recommendations intended to provide best-practice SPECT quantification-based guidance for radionuclide dosimetry. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Nuclear Medicine
volume
53
issue
8
pages
1310 - 1325
publisher
Society of Nuclear Medicine
external identifiers
  • WOS:000307201300034
  • Scopus:84864751150
ISSN
0161-5505
DOI
10.2967/jnumed.111.100123
language
English
LU publication?
yes
id
a2367947-150b-495a-8e87-dbc9694100a6 (old id 3053203)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/22743252
date added to LUP
2012-12-17 11:48:48
date last changed
2016-10-13 04:24:40
@misc{a2367947-150b-495a-8e87-dbc9694100a6,
  abstract     = {In internal radionuclide therapy, a growing interest in voxel-level estimates of tissue-absorbed dose has been driven by the desire to report radiobiologic quantities that account for the biologic consequences of both spatial and temporal nonuniformities in these dose estimates. This report presents an overview of 3-dimensional SPECT methods and requirements for internal dosimetry at both regional and voxel levels. Combined SPECT/CT image-based methods are emphasized, because the CT-derived anatomic information allows one to address multiple technical factors that affect SPECT quantification while facilitating the patient-specific voxel-level dosimetry calculation itself. SPECT imaging and reconstruction techniques for quantification in radionuclide therapy are not necessarily the same as those designed to optimize diagnostic imaging quality. The current overview is intended as an introduction to an upcoming series of MIRD pamphlets with detailed radionuclide-specific recommendations intended to provide best-practice SPECT quantification-based guidance for radionuclide dosimetry.},
  author       = {Dewaraja, Y. K. and Frey, E. C. and Sgouros, G. and Brill, A. B. and Roberson, P. and Zanzonico, P. B. and Ljungberg, Michael},
  issn         = {0161-5505},
  language     = {eng},
  number       = {8},
  pages        = {1310--1325},
  publisher    = {ARRAY(0xaefdde0)},
  series       = {Journal of Nuclear Medicine},
  title        = {MIRD Pamphlet No. 23: Quantitative SPECT for Patient-Specific 3-Dimensional Dosimetry in Internal Radionuclide Therapy},
  url          = {http://dx.doi.org/10.2967/jnumed.111.100123},
  volume       = {53},
  year         = {2012},
}