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A hypothesis about tumour development and the clinical features of hereditary breast cancers

Olsson, H LU (2001) In European Journal of Cancer 37(16). p.2023-2029
Abstract

A unifying hypothesis is presented about tumour biology in hereditary breast cancer in relation to the epithelial origin and the degree of differentiation of the normal epithelium at the time of tumour initiation. By using different breast cancer syndromes as examples, it is possible to, at least partly, predict the tumour biology, clinical presentation and therapeutic response.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Adult, Ataxia Telangiectasia Mutated Proteins, Breast Neoplasms, Cell Cycle Proteins, Cell Transformation, Neoplastic, DNA-Binding Proteins, Female, Genes, BRCA1, Genes, BRCA2, Genes, p53, Humans, Middle Aged, Mutation, Neoplasm Proteins, Neoplastic Syndromes, Hereditary, Protein-Serine-Threonine Kinases, Tumor Suppressor Proteins
in
European Journal of Cancer
volume
37
issue
16
pages
2023 - 2029
publisher
Elsevier
external identifiers
  • Scopus:0034774288
ISSN
0959-8049
language
English
LU publication?
yes
id
306100e1-cdff-472c-b336-3b3ad4eb66ce
date added to LUP
2016-09-18 12:23:09
date last changed
2016-10-13 05:13:41
@misc{306100e1-cdff-472c-b336-3b3ad4eb66ce,
  abstract     = {<p>A unifying hypothesis is presented about tumour biology in hereditary breast cancer in relation to the epithelial origin and the degree of differentiation of the normal epithelium at the time of tumour initiation. By using different breast cancer syndromes as examples, it is possible to, at least partly, predict the tumour biology, clinical presentation and therapeutic response.</p>},
  author       = {Olsson, H},
  issn         = {0959-8049},
  keyword      = {Adult,Ataxia Telangiectasia Mutated Proteins,Breast Neoplasms,Cell Cycle Proteins,Cell Transformation, Neoplastic,DNA-Binding Proteins,Female,Genes, BRCA1,Genes, BRCA2,Genes, p53,Humans,Middle Aged,Mutation,Neoplasm Proteins,Neoplastic Syndromes, Hereditary,Protein-Serine-Threonine Kinases,Tumor Suppressor Proteins},
  language     = {eng},
  number       = {16},
  pages        = {2023--2029},
  publisher    = {ARRAY(0x90be9e0)},
  series       = {European Journal of Cancer},
  title        = {A hypothesis about tumour development and the clinical features of hereditary breast cancers},
  volume       = {37},
  year         = {2001},
}