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Orosomucoid, carotid plaque, and incidence of stroke

Berntsson, John LU ; Östling, Gerd LU ; Persson, Margaretha LU ; Smith, J. Gustav; Hedblad, Bo LU and Engström, Gunnar LU (2016) In Stroke: a journal of cerebral circulation 47(7). p.1858-1863
Abstract

Background and Purpose - Orosomucoid (α-1-acid glycoprotein) is an acute-phase protein that has been implicated in anti-inflammatory, immunomodulating, and angiogenic pathways. Orosomucoid has also been associated with coronary disease and stroke. The relationship between orosomucoid, carotid plaque, and stroke incidence were explored in this study. Methods - Plasma levels of orosomucoid were assessed in 4285 subjects (39.8% men; mean age 57.5±5.9 years) without cardiovascular disease, who participated in the Malmö Diet and Cancer Study, between 1991 and 1994. The right carotid artery was examined for plaque using B-mode ultrasound examination. Incidence of stroke was followed up during a median follow-up time of 17.7 years. Results -... (More)

Background and Purpose - Orosomucoid (α-1-acid glycoprotein) is an acute-phase protein that has been implicated in anti-inflammatory, immunomodulating, and angiogenic pathways. Orosomucoid has also been associated with coronary disease and stroke. The relationship between orosomucoid, carotid plaque, and stroke incidence were explored in this study. Methods - Plasma levels of orosomucoid were assessed in 4285 subjects (39.8% men; mean age 57.5±5.9 years) without cardiovascular disease, who participated in the Malmö Diet and Cancer Study, between 1991 and 1994. The right carotid artery was examined for plaque using B-mode ultrasound examination. Incidence of stroke was followed up during a median follow-up time of 17.7 years. Results - Carotid plaque was present in 43.5% at baseline. Orosomucoid was significantly higher in subjects with carotid plaque (mean±SD: 0.72±0.22 versus 0.69±0.20 g/L; P

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Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
acute-phase reaction, carotid artery disease, cytokines, risk factor, stroke
in
Stroke: a journal of cerebral circulation
volume
47
issue
7
pages
6 pages
publisher
American Heart Association
external identifiers
  • Scopus:84974807325
ISSN
0039-2499
DOI
10.1161/STROKEAHA.116.013374
language
English
LU publication?
yes
id
30ab59ce-d947-4e92-8076-a6a24445beac
date added to LUP
2016-07-11 15:54:50
date last changed
2016-09-20 03:07:52
@misc{30ab59ce-d947-4e92-8076-a6a24445beac,
  abstract     = {<p>Background and Purpose - Orosomucoid (α-1-acid glycoprotein) is an acute-phase protein that has been implicated in anti-inflammatory, immunomodulating, and angiogenic pathways. Orosomucoid has also been associated with coronary disease and stroke. The relationship between orosomucoid, carotid plaque, and stroke incidence were explored in this study. Methods - Plasma levels of orosomucoid were assessed in 4285 subjects (39.8% men; mean age 57.5±5.9 years) without cardiovascular disease, who participated in the Malmö Diet and Cancer Study, between 1991 and 1994. The right carotid artery was examined for plaque using B-mode ultrasound examination. Incidence of stroke was followed up during a median follow-up time of 17.7 years. Results - Carotid plaque was present in 43.5% at baseline. Orosomucoid was significantly higher in subjects with carotid plaque (mean±SD: 0.72±0.22 versus 0.69±0.20 g/L; P</p>},
  author       = {Berntsson, John and Östling, Gerd and Persson, Margaretha and Smith, J. Gustav and Hedblad, Bo and Engström, Gunnar},
  issn         = {0039-2499},
  keyword      = {acute-phase reaction,carotid artery disease,cytokines,risk factor,stroke},
  language     = {eng},
  month        = {07},
  number       = {7},
  pages        = {1858--1863},
  publisher    = {ARRAY(0x7ed85c8)},
  series       = { Stroke: a journal of cerebral circulation},
  title        = {Orosomucoid, carotid plaque, and incidence of stroke},
  url          = {http://dx.doi.org/10.1161/STROKEAHA.116.013374},
  volume       = {47},
  year         = {2016},
}