Both Low and High Serum IGF-I Levels Associate with Cancer Mortality in Older Men.
(2012) In The Journal of clinical endocrinology and metabolism- Abstract
- Background:
Although recent population-based studies suggest a U-shaped relationship between serum IGF-I concentration and all-cause mortality, the distribution of death causes underlying this association remains unclear. We hypothesized that high IGF-I levels associate with increased cancer mortality, whereas low IGF-I levels associate with increased cardiovascular disease (CVD) mortality.
Methods:
Serum IGF-I levels were measured in 2901 elderly men (mean age 75.4, range 69-81 yr) included in the prospective population-based Osteoporotic Fractures in Men Study (Sweden) study. Mortality data were obtained from central registers with no loss of follow-up. The statistical analyses included Cox... (More) - Background:
Although recent population-based studies suggest a U-shaped relationship between serum IGF-I concentration and all-cause mortality, the distribution of death causes underlying this association remains unclear. We hypothesized that high IGF-I levels associate with increased cancer mortality, whereas low IGF-I levels associate with increased cardiovascular disease (CVD) mortality.
Methods:
Serum IGF-I levels were measured in 2901 elderly men (mean age 75.4, range 69-81 yr) included in the prospective population-based Osteoporotic Fractures in Men Study (Sweden) study. Mortality data were obtained from central registers with no loss of follow-up. The statistical analyses included Cox proportional hazards regressions with or without a spline approach.
Results:
During the follow-up (mean 6.0 yr), 586 of the participants died (cancer deaths, n = 211; CVD deaths, n = 214). As expected, our data revealed a U-shaped association between serum IGF-I levels and all-cause mortality. Low as well as high serum IGF-I (quintile 1 or 5 vs. quintiles 2-4) associated with increased cancer mortality [hazard ratio (HR) = 1.86, 95% confidence interval (CI) = 1.34-2.58; and HR = 1.90, 95% CI = 1.37-2.65, respectively]. Only low serum IGF-I associated with increased CVD mortality (quintile 1 vs. quintiles 2-4, HR = 1.48, 95% CI = 1.08-2.04). These associations remained after adjustment for multiple covariates and exclusion of men who died during the first 2 yr of follow-up.Conclusions:Our findings demonstrate that both low and high serum IGF-I levels are risk markers for increased cancer mortality in older men. Moreover, low IGF-I levels associate with increased CVD mortality. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/3123592
- author
- Svensson, Johan ; Carlzon, Daniel ; Petzold, Max ; Karlsson, Magnus LU ; Ljunggren, Osten ; Tivesten, Asa ; Mellström, Dan and Ohlsson, Claes
- organization
- publishing date
- 2012-09-26
- type
- Contribution to journal
- publication status
- published
- subject
- in
- The Journal of clinical endocrinology and metabolism
- publisher
- Oxford University Press
- external identifiers
-
- wos:000312003900064
- pmid:23015658
- scopus:84870728818
- pmid:23015658
- ISSN
- 1945-7197
- DOI
- 10.1210/jc.2012-2329
- language
- English
- LU publication?
- yes
- id
- fbf8202b-ac72-49c5-87ef-8e1d0074d533 (old id 3123592)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/23015658?dopt=Abstract
- date added to LUP
- 2016-04-04 09:14:33
- date last changed
- 2022-02-20 23:54:32
@article{fbf8202b-ac72-49c5-87ef-8e1d0074d533,
abstract = {{Background:<br/><br>
Although recent population-based studies suggest a U-shaped relationship between serum IGF-I concentration and all-cause mortality, the distribution of death causes underlying this association remains unclear. We hypothesized that high IGF-I levels associate with increased cancer mortality, whereas low IGF-I levels associate with increased cardiovascular disease (CVD) mortality.<br/><br>
<br/><br>
Methods:<br/><br>
Serum IGF-I levels were measured in 2901 elderly men (mean age 75.4, range 69-81 yr) included in the prospective population-based Osteoporotic Fractures in Men Study (Sweden) study. Mortality data were obtained from central registers with no loss of follow-up. The statistical analyses included Cox proportional hazards regressions with or without a spline approach.<br/><br>
<br/><br>
Results:<br/><br>
During the follow-up (mean 6.0 yr), 586 of the participants died (cancer deaths, n = 211; CVD deaths, n = 214). As expected, our data revealed a U-shaped association between serum IGF-I levels and all-cause mortality. Low as well as high serum IGF-I (quintile 1 or 5 vs. quintiles 2-4) associated with increased cancer mortality [hazard ratio (HR) = 1.86, 95% confidence interval (CI) = 1.34-2.58; and HR = 1.90, 95% CI = 1.37-2.65, respectively]. Only low serum IGF-I associated with increased CVD mortality (quintile 1 vs. quintiles 2-4, HR = 1.48, 95% CI = 1.08-2.04). These associations remained after adjustment for multiple covariates and exclusion of men who died during the first 2 yr of follow-up.Conclusions:Our findings demonstrate that both low and high serum IGF-I levels are risk markers for increased cancer mortality in older men. Moreover, low IGF-I levels associate with increased CVD mortality.}},
author = {{Svensson, Johan and Carlzon, Daniel and Petzold, Max and Karlsson, Magnus and Ljunggren, Osten and Tivesten, Asa and Mellström, Dan and Ohlsson, Claes}},
issn = {{1945-7197}},
language = {{eng}},
month = {{09}},
publisher = {{Oxford University Press}},
series = {{The Journal of clinical endocrinology and metabolism}},
title = {{Both Low and High Serum IGF-I Levels Associate with Cancer Mortality in Older Men.}},
url = {{http://dx.doi.org/10.1210/jc.2012-2329}},
doi = {{10.1210/jc.2012-2329}},
year = {{2012}},
}