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Incidence, prevalence and clinical characteristics of Behcet's disease in southern Sweden.

Mohammad, Aladdin LU ; Mandl, Thomas LU ; Sturfelt, Gunnar LU and Segelmark, Mårten LU (2012) In Rheumatology (Oxford, England)
Abstract
Objective:

To study the incidence, prevalence and clinical characteristics of Behçet's disease (BD) in a defined population in southern Sweden.



Methods:

The study area consists of three health-care districts with an adult population (≥15 years) of 809 317 on 1 January 2011 (25% of non-Swedish ancestry), situated in Skåne, the southernmost county in Sweden. Patients were identified using clinical registries in all the five hospitals within the study area. Only patients fulfilling the International Study Group criteria for diagnosis of BD were included.Results. Forty patients (13 women) fulfilling the diagnosis criteria for BD (70% of non-Swedish ancestry) were identified. The point prevalence of BD on 1... (More)
Objective:

To study the incidence, prevalence and clinical characteristics of Behçet's disease (BD) in a defined population in southern Sweden.



Methods:

The study area consists of three health-care districts with an adult population (≥15 years) of 809 317 on 1 January 2011 (25% of non-Swedish ancestry), situated in Skåne, the southernmost county in Sweden. Patients were identified using clinical registries in all the five hospitals within the study area. Only patients fulfilling the International Study Group criteria for diagnosis of BD were included.Results. Forty patients (13 women) fulfilling the diagnosis criteria for BD (70% of non-Swedish ancestry) were identified. The point prevalence of BD on 1 January 2011 was 4.9/100 000 adults (95% CI 3.4, 6.5) and was higher among the population of non-Swedish ancestry (13.6 vs 2.0/100 000, P < 0.001), and higher among men (6.8 vs 3.2/100 000, P = 0.019). There were 20 incident cases (diagnosed in Sweden between 1997 and 2010). The annual incidence rate was 0.2/100 000 adults (95% CI 0.1, 0.3) and was higher among the population of non-Swedish ancestry (0.6 vs 0.1/100 000, P < 0.001). The incidence was 0.3/100 000 adults in men and 0.1/100 000 in women, P = 0.143. During the course of the disease, 100% of the patients developed oral ulceration, 80% genital ulcers, 88% skin lesions, 53% eye disease, 40% arthritis/arthralgia and 20% venous thrombosis.



Conclusion:

The prevalence of BD is higher in Sweden than previously reported, mainly due to immigration. The incidence of BD remains elevated for immigrants from high-prevalence regions even long after settling in Sweden. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Rheumatology (Oxford, England)
publisher
Oxford University Press
external identifiers
  • WOS:000314054800013
  • PMID:23012468
  • Scopus:84873878941
ISSN
1462-0332
DOI
10.1093/rheumatology/kes249
language
English
LU publication?
yes
id
4df262a0-6292-4bf7-bdb0-8b15cc47906d (old id 3123642)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/23012468?dopt=Abstract
date added to LUP
2012-10-03 20:57:25
date last changed
2016-10-13 15:12:32
@misc{4df262a0-6292-4bf7-bdb0-8b15cc47906d,
  abstract     = {Objective:<br/><br>
To study the incidence, prevalence and clinical characteristics of Behçet's disease (BD) in a defined population in southern Sweden.<br/><br>
<br/><br>
Methods:<br/><br>
The study area consists of three health-care districts with an adult population (≥15 years) of 809 317 on 1 January 2011 (25% of non-Swedish ancestry), situated in Skåne, the southernmost county in Sweden. Patients were identified using clinical registries in all the five hospitals within the study area. Only patients fulfilling the International Study Group criteria for diagnosis of BD were included.Results. Forty patients (13 women) fulfilling the diagnosis criteria for BD (70% of non-Swedish ancestry) were identified. The point prevalence of BD on 1 January 2011 was 4.9/100 000 adults (95% CI 3.4, 6.5) and was higher among the population of non-Swedish ancestry (13.6 vs 2.0/100 000, P &lt; 0.001), and higher among men (6.8 vs 3.2/100 000, P = 0.019). There were 20 incident cases (diagnosed in Sweden between 1997 and 2010). The annual incidence rate was 0.2/100 000 adults (95% CI 0.1, 0.3) and was higher among the population of non-Swedish ancestry (0.6 vs 0.1/100 000, P &lt; 0.001). The incidence was 0.3/100 000 adults in men and 0.1/100 000 in women, P = 0.143. During the course of the disease, 100% of the patients developed oral ulceration, 80% genital ulcers, 88% skin lesions, 53% eye disease, 40% arthritis/arthralgia and 20% venous thrombosis.<br/><br>
<br/><br>
Conclusion:<br/><br>
The prevalence of BD is higher in Sweden than previously reported, mainly due to immigration. The incidence of BD remains elevated for immigrants from high-prevalence regions even long after settling in Sweden.},
  author       = {Mohammad, Aladdin and Mandl, Thomas and Sturfelt, Gunnar and Segelmark, Mårten},
  issn         = {1462-0332},
  language     = {eng},
  month        = {09},
  publisher    = {ARRAY(0x894b5a0)},
  series       = {Rheumatology (Oxford, England)},
  title        = {Incidence, prevalence and clinical characteristics of Behcet's disease in southern Sweden.},
  url          = {http://dx.doi.org/10.1093/rheumatology/kes249},
  year         = {2012},
}