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Eradication of nasopharyngeal carriage of penicillin-non-susceptible Streptococcus pneumoniae-is it possible?

Hellberg, Maria LU ; Johansson, Sandra; Ahl, Jonas LU ; Odenholt, Inga LU ; Holmdahl, Torsten LU ; Ringberg, Håkan; Nilsson Wimar, Percy LU and Norrgren, Hans LU (2012) In Scandinavian Journal of Infectious Diseases 44(12). p.909-914
Abstract
Background: The South Swedish Pneumococcal Intervention Project (SSPIP) was started in 1995 with the aim of limiting the spread of penicillin-non-susceptible pneumococci (PNSP) in Skåne County, Sweden. As part of the SSPIP, eradication therapy with rifampicin in combination with 1 more antibiotic was considered on a social indication after prolonged carriage of 2-3 months. Methods: In this retrospective study, 125 medical records were analyzed. Children aged 0-10 y referred for eradication therapy in Malmö and Lund, due to a prolonged nasopharyngeal carriage of PNSP with a penicillin G minimum inhibitory concentration of ≥ 0.5 mg/l, between the y 1997 and 2011 were included. Two consecutive negative cultures, with the second one no shorter... (More)
Background: The South Swedish Pneumococcal Intervention Project (SSPIP) was started in 1995 with the aim of limiting the spread of penicillin-non-susceptible pneumococci (PNSP) in Skåne County, Sweden. As part of the SSPIP, eradication therapy with rifampicin in combination with 1 more antibiotic was considered on a social indication after prolonged carriage of 2-3 months. Methods: In this retrospective study, 125 medical records were analyzed. Children aged 0-10 y referred for eradication therapy in Malmö and Lund, due to a prolonged nasopharyngeal carriage of PNSP with a penicillin G minimum inhibitory concentration of ≥ 0.5 mg/l, between the y 1997 and 2011 were included. Two consecutive negative cultures, with the second one no shorter than 7 days after treatment completion, were required for the carriage to be considered eradicated. Results: Out of 125 children, 71 received treatment with rifampicin in combination with amoxicillin (n = 44), erythromycin (n = 22), or clindamycin (n = 5) for 7 days. Eradication treatment was successful in 91.5% of the children. Six children (8.5%) had treatment failure with amoxicillin and rifampicin; 3 were found by late follow-up. There was a trend towards a better outcome with erythromycin and clindamycin combinations in comparison to amoxicillin. Conclusions: Eradication therapy was successful, but a proper follow-up is essential. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Scandinavian Journal of Infectious Diseases
volume
44
issue
12
pages
909 - 914
publisher
Informa Healthcare
external identifiers
  • WOS:000311127800003
  • PMID:22991948
  • Scopus:84874184479
ISSN
1651-1980
DOI
10.3109/00365548.2012.697636
language
English
LU publication?
yes
id
c9d86865-911c-45b9-ab16-1f0752e4e31d (old id 3123859)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/22991948?dopt=Abstract
date added to LUP
2012-10-03 22:09:47
date last changed
2016-10-13 04:32:12
@misc{c9d86865-911c-45b9-ab16-1f0752e4e31d,
  abstract     = {Background: The South Swedish Pneumococcal Intervention Project (SSPIP) was started in 1995 with the aim of limiting the spread of penicillin-non-susceptible pneumococci (PNSP) in Skåne County, Sweden. As part of the SSPIP, eradication therapy with rifampicin in combination with 1 more antibiotic was considered on a social indication after prolonged carriage of 2-3 months. Methods: In this retrospective study, 125 medical records were analyzed. Children aged 0-10 y referred for eradication therapy in Malmö and Lund, due to a prolonged nasopharyngeal carriage of PNSP with a penicillin G minimum inhibitory concentration of ≥ 0.5 mg/l, between the y 1997 and 2011 were included. Two consecutive negative cultures, with the second one no shorter than 7 days after treatment completion, were required for the carriage to be considered eradicated. Results: Out of 125 children, 71 received treatment with rifampicin in combination with amoxicillin (n = 44), erythromycin (n = 22), or clindamycin (n = 5) for 7 days. Eradication treatment was successful in 91.5% of the children. Six children (8.5%) had treatment failure with amoxicillin and rifampicin; 3 were found by late follow-up. There was a trend towards a better outcome with erythromycin and clindamycin combinations in comparison to amoxicillin. Conclusions: Eradication therapy was successful, but a proper follow-up is essential.},
  author       = {Hellberg, Maria and Johansson, Sandra and Ahl, Jonas and Odenholt, Inga and Holmdahl, Torsten and Ringberg, Håkan and Nilsson Wimar, Percy and Norrgren, Hans},
  issn         = {1651-1980},
  language     = {eng},
  number       = {12},
  pages        = {909--914},
  publisher    = {ARRAY(0x8b89990)},
  series       = {Scandinavian Journal of Infectious Diseases},
  title        = {Eradication of nasopharyngeal carriage of penicillin-non-susceptible Streptococcus pneumoniae-is it possible?},
  url          = {http://dx.doi.org/10.3109/00365548.2012.697636},
  volume       = {44},
  year         = {2012},
}