Impairment and recovery of postural control in rabbits with spinal cord lesions.

Lyalka, V F; Zelenin, P V; Nyström, Anastasia; Orlovsky, G N; Grillner, S; Deliagina, T G

Impairment and recovery of postural control in rabbits with spinal cord lesions.

Mark

Lyalka, V F ; Zelenin, P V ; Nyström, Anastasia ^LU ; Orlovsky, G N ; Grillner, S and Deliagina, T G (2005) In Journal of Neurophysiology 94(6). p.90-3677

Abstract: The aim of this study was to characterize impairment and subsequent recovery of postural control after spinal cord injuries. Experiments were carried out on rabbits with three types of lesion--a dorsal (D), lateral (L), or ventral (V) hemisection (HS) at T(12) level. The animals were maintaining equilibrium on a platform periodically tilted in the frontal plane. We assessed the postural limb/trunk configuration from video recordings and postural reflexes in the hindquarters from kinematical and electromyographic (EMG) recordings. We found that for a few days after DHS or LHS, the animals were not able to maintain the dorsal-side-up position of their hindquarters. This ability was then gradually restored, and the dynamic postural reflexes... (More); The aim of this study was to characterize impairment and subsequent recovery of postural control after spinal cord injuries. Experiments were carried out on rabbits with three types of lesion--a dorsal (D), lateral (L), or ventral (V) hemisection (HS) at T(12) level. The animals were maintaining equilibrium on a platform periodically tilted in the frontal plane. We assessed the postural limb/trunk configuration from video recordings and postural reflexes in the hindquarters from kinematical and electromyographic (EMG) recordings. We found that for a few days after DHS or LHS, the animals were not able to maintain the dorsal-side-up position of their hindquarters. This ability was then gradually restored, and the dynamic postural reflexes reached the prelesion value within 2-3 wk. By contrast, a VHS almost completely abolished postural reflexes, and they did not recover for > or =7 wk. The DHS, LHS, and VHS caused immediate and slowly compensated changes in the postural limb/trunk configuration as well as gradually developing changes. After DHS, both hind limbs were placed in an abnormal rostral and medial position. After LHS, the limb on the undamaged side was turned inward and occurred at the abnormal medial position; LHS also caused a gradually developing twisting of the caudal trunk. VHS caused gradually developing extension of the ankle and knee joints. These findings show that ventral spinal pathways are of crucial importance for postural control. When a part of these pathways is spared, postural reflexes can be restored rapidly, but not the postural limb/trunk configuration. Spinal and supraspinal mechanisms responsible for postural deficits and their compensation are discussed. (Less)

Please use this url to cite or link to this publication: https://lup.lub.lu.se/record/3132175

author

Lyalka, V F ; Zelenin, P V ; Nyström, Anastasia ^LU ; Orlovsky, G N ; Grillner, S and Deliagina, T G

publishing date

2005

type

Contribution to journal

publication status

published

subject

Otorhinolaryngology

keywords

Postural Balance, Skeletal, Muscle, Movement, Neurological, Models, Functional Laterality, Extremities, Electromyography, Animal, Disease Models, Animals, Biomechanics, Posture, Psychomotor Performance, Rabbits, Recovery of Function, Reflex, Spinal Cord Injuries, Time Factors

in

Journal of Neurophysiology

volume

94

issue

6

pages

90 - 3677

publisher

American Physiological Society

external identifiers

scopus:28044453707

ISSN

0022-3077

language

English

LU publication?

no

id

cac8d437-75fb-4f95-b406-621e61fb5928 (old id 3132175)

alternative location

http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=16049143&ordinalpos=3&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum

http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&DbFrom=pubmed&Cmd=Link&LinkName=pubmed_pubmed&LinkReadableName=Related%20Articles&IdsFromResult=16049143&ordinalpos=3&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum

date added to LUP

2016-04-04 09:32:58

date last changed

2024-01-12 15:03:00

@article{cac8d437-75fb-4f95-b406-621e61fb5928,
  abstract     = {{The aim of this study was to characterize impairment and subsequent recovery of postural control after spinal cord injuries. Experiments were carried out on rabbits with three types of lesion--a dorsal (D), lateral (L), or ventral (V) hemisection (HS) at T(12) level. The animals were maintaining equilibrium on a platform periodically tilted in the frontal plane. We assessed the postural limb/trunk configuration from video recordings and postural reflexes in the hindquarters from kinematical and electromyographic (EMG) recordings. We found that for a few days after DHS or LHS, the animals were not able to maintain the dorsal-side-up position of their hindquarters. This ability was then gradually restored, and the dynamic postural reflexes reached the prelesion value within 2-3 wk. By contrast, a VHS almost completely abolished postural reflexes, and they did not recover for &gt; or =7 wk. The DHS, LHS, and VHS caused immediate and slowly compensated changes in the postural limb/trunk configuration as well as gradually developing changes. After DHS, both hind limbs were placed in an abnormal rostral and medial position. After LHS, the limb on the undamaged side was turned inward and occurred at the abnormal medial position; LHS also caused a gradually developing twisting of the caudal trunk. VHS caused gradually developing extension of the ankle and knee joints. These findings show that ventral spinal pathways are of crucial importance for postural control. When a part of these pathways is spared, postural reflexes can be restored rapidly, but not the postural limb/trunk configuration. Spinal and supraspinal mechanisms responsible for postural deficits and their compensation are discussed.}},
  author       = {{Lyalka, V F and Zelenin, P V and Nyström, Anastasia and Orlovsky, G N and Grillner, S and Deliagina, T G}},
  issn         = {{0022-3077}},
  keywords     = {{Postural Balance; Skeletal; Muscle; Movement; Neurological; Models; Functional Laterality; Extremities; Electromyography; Animal; Disease Models; Animals; Biomechanics; Posture; Psychomotor Performance; Rabbits; Recovery of Function; Reflex; Spinal Cord Injuries; Time Factors}},
  language     = {{eng}},
  number       = {{6}},
  pages        = {{90--3677}},
  publisher    = {{American Physiological Society}},
  series       = {{Journal of Neurophysiology}},
  title        = {{Impairment and recovery of postural control in rabbits with spinal cord lesions.}},
  url          = {{http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=16049143&ordinalpos=3&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum}},
  volume       = {{94}},
  year         = {{2005}},
}

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Impairment and recovery of postural control in rabbits with spinal cord lesions.