Multimodal management of colorectal liver metastases and the effect on regeneration and outcome after liver resection.
(2012) In Scandinavian Journal of Gastroenterology- Abstract
- Abstract Management of colorectal liver metastases (CRLM) has dramatically changed during the last decade and has now become more multimodal and aggressive, including the use of downstaging chemotherapy, portal vein embolization to increase the function of the liver remnant or both in combination. Radiofrequency ablation is also an option in CRLM, potentially combined with surgical resection. Results are quite convincing concerning the safety of liver resection also when performed following neoadjuvant chemotherapy. Sparing liver parenchyma in patients with bilobar liver metastatic disease subjected to liver resection may be possible without endangering surgical radicality. Sparing liver parenchyma when using neoadjuvant chemotherapy, a... (More)
- Abstract Management of colorectal liver metastases (CRLM) has dramatically changed during the last decade and has now become more multimodal and aggressive, including the use of downstaging chemotherapy, portal vein embolization to increase the function of the liver remnant or both in combination. Radiofrequency ablation is also an option in CRLM, potentially combined with surgical resection. Results are quite convincing concerning the safety of liver resection also when performed following neoadjuvant chemotherapy. Sparing liver parenchyma in patients with bilobar liver metastatic disease subjected to liver resection may be possible without endangering surgical radicality. Sparing liver parenchyma when using neoadjuvant chemotherapy, a chemotherapy-free period of 6 weeks or more seems to positively affect liver regeneration. There is still the possibility to reresect recurrent liver lesions, though there seems to be a tendency toward fewer reresections following the use of adjuvant chemotherapy. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/3161119
- author
- Ansari, Daniel LU ; Bergenfeldt, Magnus LU ; Tingstedt, Bobby LU and Andersson, Roland LU
- organization
- publishing date
- 2012-10-04
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Scandinavian Journal of Gastroenterology
- publisher
- Taylor & Francis
- external identifiers
-
- wos:000312427800008
- pmid:23035803
- scopus:84870018867
- ISSN
- 1502-7708
- DOI
- 10.3109/00365521.2012.729083
- language
- English
- LU publication?
- yes
- id
- 0c2680f7-fc94-42d6-9639-6c3f93cc331b (old id 3161119)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/23035803?dopt=Abstract
- date added to LUP
- 2016-04-04 09:35:48
- date last changed
- 2022-01-29 18:37:57
@article{0c2680f7-fc94-42d6-9639-6c3f93cc331b,
abstract = {{Abstract Management of colorectal liver metastases (CRLM) has dramatically changed during the last decade and has now become more multimodal and aggressive, including the use of downstaging chemotherapy, portal vein embolization to increase the function of the liver remnant or both in combination. Radiofrequency ablation is also an option in CRLM, potentially combined with surgical resection. Results are quite convincing concerning the safety of liver resection also when performed following neoadjuvant chemotherapy. Sparing liver parenchyma in patients with bilobar liver metastatic disease subjected to liver resection may be possible without endangering surgical radicality. Sparing liver parenchyma when using neoadjuvant chemotherapy, a chemotherapy-free period of 6 weeks or more seems to positively affect liver regeneration. There is still the possibility to reresect recurrent liver lesions, though there seems to be a tendency toward fewer reresections following the use of adjuvant chemotherapy.}},
author = {{Ansari, Daniel and Bergenfeldt, Magnus and Tingstedt, Bobby and Andersson, Roland}},
issn = {{1502-7708}},
language = {{eng}},
month = {{10}},
publisher = {{Taylor & Francis}},
series = {{Scandinavian Journal of Gastroenterology}},
title = {{Multimodal management of colorectal liver metastases and the effect on regeneration and outcome after liver resection.}},
url = {{http://dx.doi.org/10.3109/00365521.2012.729083}},
doi = {{10.3109/00365521.2012.729083}},
year = {{2012}},
}