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Hypoxic conditions induce a cancer-like phenotype in human breast epithelial cells.

Vaapil, Marica LU ; Helczynska, Karolina LU ; Villadsen, René; Petersen, Ole W; Johansson, Elisabet LU ; Beckman, Siv LU ; Larsson, Christer LU ; Påhlman, Sven LU and Jögi, Annika LU (2012) In PLoS One 7(9).
Abstract
Solid tumors are less oxygenated than their tissue of origin. Low intra-tumor oxygen levels are associated with worse outcome, increased metastatic potential and immature phenotype in breast cancer. We have reported that tumor hypoxia correlates to low differentiation status in breast cancer. Less is known about effects of hypoxia on non-malignant cells. Here we address whether hypoxia influences the differentiation stage of non-malignant breast epithelial cells and potentially have bearing on early stages of tumorigenesis.
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
hypoxia, Breast cancer, differentiation, epithelial cells
in
PLoS One
volume
7
issue
9
publisher
Public Library of Science
external identifiers
  • WOS:000309973900183
  • PMID:23029547
  • Scopus:84866984248
ISSN
1932-6203
DOI
10.1371/journal.pone.0046543
language
English
LU publication?
yes
id
088dcd0e-5e2b-40f0-a26f-5f089f466440 (old id 3161219)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/23029547?dopt=Abstract
date added to LUP
2012-11-01 12:28:40
date last changed
2016-10-13 04:30:30
@misc{088dcd0e-5e2b-40f0-a26f-5f089f466440,
  abstract     = {Solid tumors are less oxygenated than their tissue of origin. Low intra-tumor oxygen levels are associated with worse outcome, increased metastatic potential and immature phenotype in breast cancer. We have reported that tumor hypoxia correlates to low differentiation status in breast cancer. Less is known about effects of hypoxia on non-malignant cells. Here we address whether hypoxia influences the differentiation stage of non-malignant breast epithelial cells and potentially have bearing on early stages of tumorigenesis.},
  author       = {Vaapil, Marica and Helczynska, Karolina and Villadsen, René and Petersen, Ole W and Johansson, Elisabet and Beckman, Siv and Larsson, Christer and Påhlman, Sven and Jögi, Annika},
  issn         = {1932-6203},
  keyword      = {hypoxia,Breast cancer,differentiation,epithelial cells},
  language     = {eng},
  number       = {9},
  publisher    = {ARRAY(0x8813bc0)},
  series       = {PLoS One},
  title        = {Hypoxic conditions induce a cancer-like phenotype in human breast epithelial cells.},
  url          = {http://dx.doi.org/10.1371/journal.pone.0046543},
  volume       = {7},
  year         = {2012},
}