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Measurement of MR signal and T2* in lung to characterize a tight skin mouse model of emphysema using single-point imaging

Olsson, Lars E LU ; Lindahl, Maria LU ; Onnervik, Per-Ola; Johansson, Lars B; Palmér, Malin; Reimer, Martina Kvist LU ; Hultin, Leif and Hockings, Paul D (2007) In Journal of Magnetic Resonance Imaging 25(3). p.94-488
Abstract

PURPOSE: To evaluate whether MRI signal and T2* measurements of lung tissue acquired at ultrashort detection times (tds) can detect emphysematous changes in lungs.

MATERIALS AND METHODS: MR signal intensity of in vivo mouse lungs was measured at 4.7 T at tds of 0.2 and 0.4 msec using single-point imaging (SPI). T2* was calculated from the measurements obtained at the two tds. Two groups of 8- and 30-week-old Tight Skin (TS) and aged-matched CB57BL/6 mice were examined. The TS mice spontaneously developed emphysema-like alveolar enlargement. In vivo micro-computed tomography (microCT) scanning and histology were used as reference methods.

RESULTS: MR signal and T2* were significantly lower in the lungs of TS mice than in... (More)

PURPOSE: To evaluate whether MRI signal and T2* measurements of lung tissue acquired at ultrashort detection times (tds) can detect emphysematous changes in lungs.

MATERIALS AND METHODS: MR signal intensity of in vivo mouse lungs was measured at 4.7 T at tds of 0.2 and 0.4 msec using single-point imaging (SPI). T2* was calculated from the measurements obtained at the two tds. Two groups of 8- and 30-week-old Tight Skin (TS) and aged-matched CB57BL/6 mice were examined. The TS mice spontaneously developed emphysema-like alveolar enlargement. In vivo micro-computed tomography (microCT) scanning and histology were used as reference methods.

RESULTS: MR signal and T2* were significantly lower in the lungs of TS mice than in controls. There were no significant differences between the different age groups. MR signal in lung parenchyma correlated linearly (P < 0.0001, r = 0.89) with microCT mass density, and T2* correlated linearly (P < 0.0001, r = -0.91) with the alveoli size (mean linear intercept [MLI]).

CONCLUSION: The MR signal intensity and T2* measured at short tds can be used as imaging biomarkers to characterize parenchyma density and alveolar size, respectively.

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author
publishing date
type
Contribution to journal
publication status
published
keywords
Age Factors, Animals, Disease Models, Animal, Disease Progression, Emphysema, Image Processing, Computer-Assisted, Imaging, Three-Dimensional, Lung, Magnetic Resonance Imaging, Mice, Signal Processing, Computer-Assisted, Tomography, X-Ray Computed
in
Journal of Magnetic Resonance Imaging
volume
25
issue
3
pages
7 pages
publisher
John Wiley & Sons
external identifiers
  • Scopus:33847651296
ISSN
1053-1807
DOI
10.1002/jmri.20840
language
English
LU publication?
no
id
31896240-951f-4139-a1a8-0a54f3b925e5
date added to LUP
2016-08-16 12:11:53
date last changed
2016-11-17 13:04:23
@misc{31896240-951f-4139-a1a8-0a54f3b925e5,
  abstract     = {<p>PURPOSE: To evaluate whether MRI signal and T2* measurements of lung tissue acquired at ultrashort detection times (tds) can detect emphysematous changes in lungs.</p><p>MATERIALS AND METHODS: MR signal intensity of in vivo mouse lungs was measured at 4.7 T at tds of 0.2 and 0.4 msec using single-point imaging (SPI). T2* was calculated from the measurements obtained at the two tds. Two groups of 8- and 30-week-old Tight Skin (TS) and aged-matched CB57BL/6 mice were examined. The TS mice spontaneously developed emphysema-like alveolar enlargement. In vivo micro-computed tomography (microCT) scanning and histology were used as reference methods.</p><p>RESULTS: MR signal and T2* were significantly lower in the lungs of TS mice than in controls. There were no significant differences between the different age groups. MR signal in lung parenchyma correlated linearly (P &lt; 0.0001, r = 0.89) with microCT mass density, and T2* correlated linearly (P &lt; 0.0001, r = -0.91) with the alveoli size (mean linear intercept [MLI]).</p><p>CONCLUSION: The MR signal intensity and T2* measured at short tds can be used as imaging biomarkers to characterize parenchyma density and alveolar size, respectively.</p>},
  author       = {Olsson, Lars E and Lindahl, Maria and Onnervik, Per-Ola and Johansson, Lars B and Palmér, Malin and Reimer, Martina Kvist and Hultin, Leif and Hockings, Paul D},
  issn         = {1053-1807},
  keyword      = {Age Factors,Animals,Disease Models, Animal,Disease Progression,Emphysema,Image Processing, Computer-Assisted,Imaging, Three-Dimensional,Lung,Magnetic Resonance Imaging,Mice,Signal Processing, Computer-Assisted,Tomography, X-Ray Computed},
  language     = {eng},
  number       = {3},
  pages        = {94--488},
  publisher    = {ARRAY(0xb02b9e8)},
  series       = {Journal of Magnetic Resonance Imaging},
  title        = {Measurement of MR signal and T2* in lung to characterize a tight skin mouse model of emphysema using single-point imaging},
  url          = {http://dx.doi.org/10.1002/jmri.20840},
  volume       = {25},
  year         = {2007},
}