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Stem cell repair of striatal ischemia.

Kokaia, Zaal LU and Lindvall, Olle LU (2012) In Progress in Brain Research 201(2012). p.35-53
Abstract
Stem cell-based approaches have promising prospects as new treatments to repair the stroke-damaged brain and promote efficient functional recovery. Studies in animal models of stroke have shown that transplantation of neural stem/progenitor cells (NSPCs) isolated from different sources can improve function not only by replacing dead neurons but also by trophic actions, modulation of inflammation, promotion of angiogenesis, and neuroprotection. Endogenous NSPCs produce new neurons following stroke and are also potential therapeutic targets. Joint efforts of basic researchers and clinicians are needed to develop safe and reproducible NSPC sources, test them in relevant animal models of stroke, and optimize the recovery of impaired functions.
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Progress in Brain Research
volume
201
issue
2012
pages
35 - 53
publisher
Elsevier
external identifiers
  • PMID:23186709
  • WOS:000349320300004
  • Scopus:84870184244
ISSN
1875-7855
DOI
10.1016/B978-0-444-59544-7.00003-2
language
English
LU publication?
yes
id
2509f514-fa72-4390-a6fd-42c24ee2866d (old id 3218447)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/23186709?dopt=Abstract
date added to LUP
2012-12-03 21:12:57
date last changed
2016-10-13 04:30:52
@misc{2509f514-fa72-4390-a6fd-42c24ee2866d,
  abstract     = {Stem cell-based approaches have promising prospects as new treatments to repair the stroke-damaged brain and promote efficient functional recovery. Studies in animal models of stroke have shown that transplantation of neural stem/progenitor cells (NSPCs) isolated from different sources can improve function not only by replacing dead neurons but also by trophic actions, modulation of inflammation, promotion of angiogenesis, and neuroprotection. Endogenous NSPCs produce new neurons following stroke and are also potential therapeutic targets. Joint efforts of basic researchers and clinicians are needed to develop safe and reproducible NSPC sources, test them in relevant animal models of stroke, and optimize the recovery of impaired functions.},
  author       = {Kokaia, Zaal and Lindvall, Olle},
  issn         = {1875-7855},
  language     = {eng},
  number       = {2012},
  pages        = {35--53},
  publisher    = {ARRAY(0x9bb37d8)},
  series       = {Progress in Brain Research},
  title        = {Stem cell repair of striatal ischemia.},
  url          = {http://dx.doi.org/10.1016/B978-0-444-59544-7.00003-2},
  volume       = {201},
  year         = {2012},
}