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Allergy to methyltetrahydrophthalic anhydride in epoxy resin workers

Nielsen, Jörn LU ; Welinder, Hans LU ; Horstmann, Vibeke LU and Skerfving, Staffan LU (1992) In British Journal of Industrial Medicine 49(11). p.769-775
Abstract
One hundred and forty four current and 26

former workers in a plant producing barrels

for rocket guns from an epoxy resin containing

methyltetrahydrophthalic anhydride

(MTHPA; time weighted average air concentration

up to 150 uglm') were studied. They

showed higher frequencies of work related

symptoms from the eyes (31 v 0%; p < 0-001),

nose (53 v 9%; p < 0-001), pharynx (26 v 6%;

p < 0-01), and asthma (11 v 0%; p < 0 05) than

33 controls. Also they had higher rates of

positive skin prick test to a conjugate of

MTHPA and human serum albumin (16 v 0%;

p < 0-01), and more had specific IgE and IgG

serum... (More)
One hundred and forty four current and 26

former workers in a plant producing barrels

for rocket guns from an epoxy resin containing

methyltetrahydrophthalic anhydride

(MTHPA; time weighted average air concentration

up to 150 uglm') were studied. They

showed higher frequencies of work related

symptoms from the eyes (31 v 0%; p < 0-001),

nose (53 v 9%; p < 0-001), pharynx (26 v 6%;

p < 0-01), and asthma (11 v 0%; p < 0 05) than

33 controls. Also they had higher rates of

positive skin prick test to a conjugate of

MTHPA and human serum albumin (16 v 0%;

p < 0-01), and more had specific IgE and IgG

serum antibodies (18 v 0%; p < 0-01 and 12 v

0%; p < 0 05 respectively). There were statistically

significant exposure-response relations

between exposure and symptoms from eyes

and upper airways, dry cough, positive skin

prick test, and specific IgE and IgG antibodies.

There was a non-significant difference in reaction

to metacholine between exposed workers

and non-smoking controls. In workers with

and without specific IgE antibodies, differences

existed in frequency of nasal secretion (54 v

23%; p < 0-05) and dry cough (38 v 12%;

p < 0-05). Workers with specific IgG had more

dry cough (38 v 12%; p < 0-05), but less symptoms

ofnon-specific bronchial hyperreactivity

(0 v 26%; p < 0-05). Atopic workers sneezed

more than non-atopic workers (65 v 30%;

p < 0-01). In a prospective study five sensitised

workers who left the factory became less reactive

to metacholine, and became symptom

free. In 41 workers who stayed, there was no

improvement, despite a 10-fold reduction in

exposure. The results show the extreme sensitising

properties ofMTHPA. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
British Journal of Industrial Medicine
volume
49
issue
11
pages
769 - 775
publisher
BMJ Publishing Group
external identifiers
  • Scopus:0026460835
language
English
LU publication?
yes
id
7c5d2b6c-ceca-42c7-8e8c-9c4c81936cfd (old id 3294508)
alternative location
http://www.jstor.org/stable/27727526
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1039324/
http://www.ncbi.nlm.nih.gov/pubmed/1463677
date added to LUP
2013-04-22 14:50:49
date last changed
2016-12-04 04:49:21
@misc{7c5d2b6c-ceca-42c7-8e8c-9c4c81936cfd,
  abstract     = {One hundred and forty four current and 26<br/><br>
former workers in a plant producing barrels<br/><br>
for rocket guns from an epoxy resin containing<br/><br>
methyltetrahydrophthalic anhydride<br/><br>
(MTHPA; time weighted average air concentration<br/><br>
up to 150 uglm') were studied. They<br/><br>
showed higher frequencies of work related<br/><br>
symptoms from the eyes (31 v 0%; p &lt; 0-001),<br/><br>
nose (53 v 9%; p &lt; 0-001), pharynx (26 v 6%;<br/><br>
p &lt; 0-01), and asthma (11 v 0%; p &lt; 0 05) than<br/><br>
33 controls. Also they had higher rates of<br/><br>
positive skin prick test to a conjugate of<br/><br>
MTHPA and human serum albumin (16 v 0%;<br/><br>
p &lt; 0-01), and more had specific IgE and IgG<br/><br>
serum antibodies (18 v 0%; p &lt; 0-01 and 12 v<br/><br>
0%; p &lt; 0 05 respectively). There were statistically<br/><br>
significant exposure-response relations<br/><br>
between exposure and symptoms from eyes<br/><br>
and upper airways, dry cough, positive skin<br/><br>
prick test, and specific IgE and IgG antibodies.<br/><br>
There was a non-significant difference in reaction<br/><br>
to metacholine between exposed workers<br/><br>
and non-smoking controls. In workers with<br/><br>
and without specific IgE antibodies, differences<br/><br>
existed in frequency of nasal secretion (54 v<br/><br>
23%; p &lt; 0-05) and dry cough (38 v 12%;<br/><br>
p &lt; 0-05). Workers with specific IgG had more<br/><br>
dry cough (38 v 12%; p &lt; 0-05), but less symptoms<br/><br>
ofnon-specific bronchial hyperreactivity<br/><br>
(0 v 26%; p &lt; 0-05). Atopic workers sneezed<br/><br>
more than non-atopic workers (65 v 30%;<br/><br>
p &lt; 0-01). In a prospective study five sensitised<br/><br>
workers who left the factory became less reactive<br/><br>
to metacholine, and became symptom<br/><br>
free. In 41 workers who stayed, there was no<br/><br>
improvement, despite a 10-fold reduction in<br/><br>
exposure. The results show the extreme sensitising<br/><br>
properties ofMTHPA.},
  author       = {Nielsen, Jörn and Welinder, Hans and Horstmann, Vibeke and Skerfving, Staffan},
  language     = {eng},
  number       = {11},
  pages        = {769--775},
  publisher    = {ARRAY(0x9e86738)},
  series       = {British Journal of Industrial Medicine},
  title        = {Allergy to methyltetrahydrophthalic anhydride in epoxy resin workers},
  volume       = {49},
  year         = {1992},
}