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Modulation of the Coagulation System During Severe Streptococcal Disease.

Shannon, Oonagh LU ; Herwald, Heiko LU and Oehmcke, Sonja LU (2012) In Current Topics in Microbiology and Immunology
Abstract
Haemostasis is maintained by a tightly regulated coagulation system that comprises platelets, procoagulant proteins, and anticoagulant proteins. During the local and systemic response to bacterial infection, the coagulation system becomes activated, and contributes to the pathophysiological response to infection. The significant human pathogen, Streptococcus pyogenes has multiple strategies to modulate coagulation. This can range from systemic activation of the intrinsic and extrinsic pathway of coagulation to local stimulation of fibrinolysis. Such diverse effects on this host system imply a finely tuned host-bacteria interaction. The molecular mechanisms that underlie this modulation of the coagulation system are discussed in this review.
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Current Topics in Microbiology and Immunology
publisher
Springer
external identifiers
  • PMID:23224709
  • WOS:000330612100009
  • Scopus:84880434656
ISSN
0070-217X
DOI
10.1007/82_2012_283
language
English
LU publication?
yes
id
36095c7b-d304-48c9-8668-00abe97f14b6 (old id 3347423)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/23224709?dopt=Abstract
date added to LUP
2013-01-02 15:01:26
date last changed
2016-11-20 04:21:31
@misc{36095c7b-d304-48c9-8668-00abe97f14b6,
  abstract     = {Haemostasis is maintained by a tightly regulated coagulation system that comprises platelets, procoagulant proteins, and anticoagulant proteins. During the local and systemic response to bacterial infection, the coagulation system becomes activated, and contributes to the pathophysiological response to infection. The significant human pathogen, Streptococcus pyogenes has multiple strategies to modulate coagulation. This can range from systemic activation of the intrinsic and extrinsic pathway of coagulation to local stimulation of fibrinolysis. Such diverse effects on this host system imply a finely tuned host-bacteria interaction. The molecular mechanisms that underlie this modulation of the coagulation system are discussed in this review.},
  author       = {Shannon, Oonagh and Herwald, Heiko and Oehmcke, Sonja},
  issn         = {0070-217X},
  language     = {eng},
  month        = {12},
  publisher    = {ARRAY(0x77d90e8)},
  series       = {Current Topics in Microbiology and Immunology},
  title        = {Modulation of the Coagulation System During Severe Streptococcal Disease.},
  url          = {http://dx.doi.org/10.1007/82_2012_283},
  year         = {2012},
}