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A method for measuring the variation of intima-media thickness during the entire cardiac cycle using B-Mode images

Erlöv, Tobias LU ; Rydén Ahlgren, Åsa LU ; Jansson, Tomas LU ; Persson, Hans W LU ; Lindström, Kjell LU ; Nilsson, Jan LU and Cinthio, Magnus LU (2012) IEEE International Ultrasonics Symposium (IUS), 2011 In 2011 IEEE International Ultrasonics Symposium (IUS) p.2126-2129
Abstract
Increased intima-media thickness (IMT) has been shown to predict cardiovascular risk, and measurement of intima-media thickness has been extensively used in medical research since the mid-1990s. IMT is conventionally measured by manual tracing, however this method is very time-consuming and suffers from large inter-observer variability. Numerous methods, both semi-automatic and fully-automatic, have been suggested to limit the influence of the observer. However, most methods only report one value per cardiac cycle instead of the variation of IMT over time. We propose a new method that measures the variation of IMT during the entire cardiac cycle. The method tracks spatial variations with compensation for both longitudinal movement and... (More)
Increased intima-media thickness (IMT) has been shown to predict cardiovascular risk, and measurement of intima-media thickness has been extensively used in medical research since the mid-1990s. IMT is conventionally measured by manual tracing, however this method is very time-consuming and suffers from large inter-observer variability. Numerous methods, both semi-automatic and fully-automatic, have been suggested to limit the influence of the observer. However, most methods only report one value per cardiac cycle instead of the variation of IMT over time. We propose a new method that measures the variation of IMT during the entire cardiac cycle. The method tracks spatial variations with compensation for both longitudinal movement and angle variations. This enables detection of positions where an inaccurate measurement of IMT has occurred. These can then be removed from the calculations in order to maximize the accuracy. The method was evaluated in vivo on 20 healthy individuals (mean age 38 years, range 25-57). The overall IMT in diastole (IMTdia) was 717+/-69 mu m and the intima-media compression (IMC) was 66+/-21 mu m which corresponds to a 9.2+/-2.6% maximal compression of the arterial wall during a cardiac cycle. The CV was 3.5% for IMTdia and 9.9% for IMC. Extending traditional IMT measurement to include also the variation of IMT during a cardiac cycle may improve the individual risk classification for cardiovascular diseases. (Less)
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author
organization
publishing date
type
Chapter in Book/Report/Conference proceeding
publication status
published
subject
keywords
intima-media thickness, intima-media compression, longitudinal movement, carotid artery, non-invasive ultrasound
in
2011 IEEE International Ultrasonics Symposium (IUS)
pages
2126 - 2129
publisher
IEEE--Institute of Electrical and Electronics Engineers Inc.
conference name
IEEE International Ultrasonics Symposium (IUS), 2011
external identifiers
  • WOS:000309918400507
  • Scopus:84869054587
ISBN
978-1-4577-1253-1
DOI
10.1109/ULTSYM.2011.0527
language
English
LU publication?
yes
id
1079f151-aaa8-4529-b498-9aa8b7795fcd (old id 3400392)
date added to LUP
2013-01-31 15:22:40
date last changed
2016-10-13 04:36:57
@misc{1079f151-aaa8-4529-b498-9aa8b7795fcd,
  abstract     = {Increased intima-media thickness (IMT) has been shown to predict cardiovascular risk, and measurement of intima-media thickness has been extensively used in medical research since the mid-1990s. IMT is conventionally measured by manual tracing, however this method is very time-consuming and suffers from large inter-observer variability. Numerous methods, both semi-automatic and fully-automatic, have been suggested to limit the influence of the observer. However, most methods only report one value per cardiac cycle instead of the variation of IMT over time. We propose a new method that measures the variation of IMT during the entire cardiac cycle. The method tracks spatial variations with compensation for both longitudinal movement and angle variations. This enables detection of positions where an inaccurate measurement of IMT has occurred. These can then be removed from the calculations in order to maximize the accuracy. The method was evaluated in vivo on 20 healthy individuals (mean age 38 years, range 25-57). The overall IMT in diastole (IMTdia) was 717+/-69 mu m and the intima-media compression (IMC) was 66+/-21 mu m which corresponds to a 9.2+/-2.6% maximal compression of the arterial wall during a cardiac cycle. The CV was 3.5% for IMTdia and 9.9% for IMC. Extending traditional IMT measurement to include also the variation of IMT during a cardiac cycle may improve the individual risk classification for cardiovascular diseases.},
  author       = {Erlöv, Tobias and Rydén Ahlgren, Åsa and Jansson, Tomas and Persson, Hans W and Lindström, Kjell and Nilsson, Jan and Cinthio, Magnus},
  isbn         = {978-1-4577-1253-1},
  keyword      = {intima-media thickness,intima-media compression,longitudinal movement,carotid artery,non-invasive ultrasound},
  language     = {eng},
  pages        = {2126--2129},
  publisher    = {ARRAY(0x9623758)},
  series       = {2011 IEEE International Ultrasonics Symposium (IUS)},
  title        = {A method for measuring the variation of intima-media thickness during the entire cardiac cycle using B-Mode images},
  url          = {http://dx.doi.org/10.1109/ULTSYM.2011.0527},
  year         = {2012},
}