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Allelic loss at chromosome 13q12-q13 is associated with poor prognosis in familial and sporadic breast cancer

van den Berg, J; Johannsson, O LU ; Håkansson, S; Olsson, Håkan LU and Borg, Åke LU (1996) In British Journal of Cancer 74(10). p.1615-1619
Abstract

Loss of heterozygosity (LOH) was analysed in 84 primary tumours from sporadic, familial and hereditary breast cancer using five microsatellite markers spanning the chromosomal region 13q12-q13 which harbours the BRCA2 breast cancer susceptibility gene, and using one other marker located within the RBI tumour-suppressor gene at 13q14. LOH at the BRCA2 region was found in 34% and at RBI in 27% of the tumours. Selective LOH at BRCA2 occurred in 7% of the tumours, whereas selective LOH at RBI was observed in another 7%. Moreover, a few tumours demonstrated a restricted deletion pattern, suggesting the presence of additional tumour-suppressor genes both proximal and distal of BRCA2. LOH at BRCA2 was significantly correlated to high S-phase... (More)

Loss of heterozygosity (LOH) was analysed in 84 primary tumours from sporadic, familial and hereditary breast cancer using five microsatellite markers spanning the chromosomal region 13q12-q13 which harbours the BRCA2 breast cancer susceptibility gene, and using one other marker located within the RBI tumour-suppressor gene at 13q14. LOH at the BRCA2 region was found in 34% and at RBI in 27% of the tumours. Selective LOH at BRCA2 occurred in 7% of the tumours, whereas selective LOH at RBI was observed in another 7%. Moreover, a few tumours demonstrated a restricted deletion pattern, suggesting the presence of additional tumour-suppressor genes both proximal and distal of BRCA2. LOH at BRCA2 was significantly correlated to high S-phase values, low oestrogen and progesterone receptor content and DNA non-diploidy. LOH at BRCA2 was also associated, albeit non-significantly, with large tumour size and the ductal and medullar histological types. No correlation was found with lymph node status, patient age or a family history of breast cancer. A highly significant and independent correlation existed between LOH at BRCA2 and early recurrence and death. LOH at RBI was not associated with the above mentioned factors or prognosis. The present study does not provide conclusive evidence that BRCA2 is the sole target for deletions at 13q12-q13 in breast tumours. However, the results suggest that inactivation of one or several tumour-suppressor genes in the 13q12-q13 region confer a strong tumour growth potential and poor prognosis in both familial and sporadic breast cancer.

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keywords
Adult, Aged, Aged, 80 and over, Alleles, BRCA2 Protein, Breast Neoplasms, Cell Division, Chromosomes, Human, Pair 13, DNA, Neoplasm, DNA, Satellite, Female, Gene Deletion, Humans, Middle Aged, Neoplasm Proteins, Polymerase Chain Reaction, Prognosis, S Phase, Transcription Factors
in
British Journal of Cancer
volume
74
issue
10
pages
1615 - 1619
publisher
Nature Publishing Group
external identifiers
  • Scopus:0029905138
ISSN
0007-0920
language
English
LU publication?
yes
id
343d5110-8b07-491f-88ad-c4e46bceb2ec
date added to LUP
2016-09-18 12:50:29
date last changed
2016-10-13 05:13:48
@misc{343d5110-8b07-491f-88ad-c4e46bceb2ec,
  abstract     = {<p>Loss of heterozygosity (LOH) was analysed in 84 primary tumours from sporadic, familial and hereditary breast cancer using five microsatellite markers spanning the chromosomal region 13q12-q13 which harbours the BRCA2 breast cancer susceptibility gene, and using one other marker located within the RBI tumour-suppressor gene at 13q14. LOH at the BRCA2 region was found in 34% and at RBI in 27% of the tumours. Selective LOH at BRCA2 occurred in 7% of the tumours, whereas selective LOH at RBI was observed in another 7%. Moreover, a few tumours demonstrated a restricted deletion pattern, suggesting the presence of additional tumour-suppressor genes both proximal and distal of BRCA2. LOH at BRCA2 was significantly correlated to high S-phase values, low oestrogen and progesterone receptor content and DNA non-diploidy. LOH at BRCA2 was also associated, albeit non-significantly, with large tumour size and the ductal and medullar histological types. No correlation was found with lymph node status, patient age or a family history of breast cancer. A highly significant and independent correlation existed between LOH at BRCA2 and early recurrence and death. LOH at RBI was not associated with the above mentioned factors or prognosis. The present study does not provide conclusive evidence that BRCA2 is the sole target for deletions at 13q12-q13 in breast tumours. However, the results suggest that inactivation of one or several tumour-suppressor genes in the 13q12-q13 region confer a strong tumour growth potential and poor prognosis in both familial and sporadic breast cancer.</p>},
  author       = {van den Berg, J and Johannsson, O and Håkansson, S and Olsson, Håkan and Borg, Åke},
  issn         = {0007-0920},
  keyword      = {Adult,Aged,Aged, 80 and over,Alleles,BRCA2 Protein,Breast Neoplasms,Cell Division,Chromosomes, Human, Pair 13,DNA, Neoplasm,DNA, Satellite,Female,Gene Deletion,Humans,Middle Aged,Neoplasm Proteins,Polymerase Chain Reaction,Prognosis,S Phase,Transcription Factors},
  language     = {eng},
  number       = {10},
  pages        = {1615--1619},
  publisher    = {ARRAY(0xade76f0)},
  series       = {British Journal of Cancer},
  title        = {Allelic loss at chromosome 13q12-q13 is associated with poor prognosis in familial and sporadic breast cancer},
  volume       = {74},
  year         = {1996},
}