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Combinations of cereal β-glucans and probiotics can enhance the anti-inflammatory activity on host cells by a synergistic effect

Arena, Mattia Pia ; Russo, Pasquale ; Capozzi, Vittorio ; Rascón, Ana LU ; Felis, Giovanna E. ; Spano, Giuseppe and Fiocco, Daniela (2016) In Journal of Functional Foods 23. p.12-23
Abstract

The influence of oat and barley β-glucans on some features of diverse probiotic strains was investigated. Neither barley nor oat β-glucans supported the growth of any of the investigated strains when used as the sole carbon source in fermentation media. No protective effect by β-glucans was observed on bacterial survival to in vitro simulation of the human digestive tract. Moreover, the presence of β-glucans did not enhance the ability of probiotic bacteria to adhere on human intestinal cells. The immunomodulatory activities of probiotics, β-glucans, and their combinations were studied and compared in vitro by transcriptional analysis of immune-related genes on LPS-stimulated THP-1 macrophages. Immune modulating properties were... (More)

The influence of oat and barley β-glucans on some features of diverse probiotic strains was investigated. Neither barley nor oat β-glucans supported the growth of any of the investigated strains when used as the sole carbon source in fermentation media. No protective effect by β-glucans was observed on bacterial survival to in vitro simulation of the human digestive tract. Moreover, the presence of β-glucans did not enhance the ability of probiotic bacteria to adhere on human intestinal cells. The immunomodulatory activities of probiotics, β-glucans, and their combinations were studied and compared in vitro by transcriptional analysis of immune-related genes on LPS-stimulated THP-1 macrophages. Immune modulating properties were evidenced. In particular, mixtures of probiotic microorganisms and barley β-glucans exhibited synergistic effects in modulating the transcriptional level of several immune-related genes, leading to an overall enhanced anti-inflammatory effect. Together, these findings suggest a promising application of probiotic bacteria and β-glucans in the preparation of dietary mixtures presenting health-promoting features such as immunomodulatory properties.

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author
; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Beta Glucan (PubChem CID: 9202437), Immune system, Prebiotics, Probiotics, Relative gene expression, Synbiotics, β-glucan
in
Journal of Functional Foods
volume
23
pages
12 pages
publisher
Elsevier
external identifiers
  • wos:000376145200002
  • scopus:84959159638
ISSN
1756-4646
DOI
10.1016/j.jff.2016.02.015
language
English
LU publication?
yes
id
3445335c-020d-4224-8714-51a188f2b38c
date added to LUP
2016-05-10 09:33:30
date last changed
2024-03-06 22:51:31
@article{3445335c-020d-4224-8714-51a188f2b38c,
  abstract     = {{<p>The influence of oat and barley β-glucans on some features of diverse probiotic strains was investigated. Neither barley nor oat β-glucans supported the growth of any of the investigated strains when used as the sole carbon source in fermentation media. No protective effect by β-glucans was observed on bacterial survival to in vitro simulation of the human digestive tract. Moreover, the presence of β-glucans did not enhance the ability of probiotic bacteria to adhere on human intestinal cells. The immunomodulatory activities of probiotics, β-glucans, and their combinations were studied and compared in vitro by transcriptional analysis of immune-related genes on LPS-stimulated THP-1 macrophages. Immune modulating properties were evidenced. In particular, mixtures of probiotic microorganisms and barley β-glucans exhibited synergistic effects in modulating the transcriptional level of several immune-related genes, leading to an overall enhanced anti-inflammatory effect. Together, these findings suggest a promising application of probiotic bacteria and β-glucans in the preparation of dietary mixtures presenting health-promoting features such as immunomodulatory properties.</p>}},
  author       = {{Arena, Mattia Pia and Russo, Pasquale and Capozzi, Vittorio and Rascón, Ana and Felis, Giovanna E. and Spano, Giuseppe and Fiocco, Daniela}},
  issn         = {{1756-4646}},
  keywords     = {{Beta Glucan (PubChem CID: 9202437); Immune system; Prebiotics; Probiotics; Relative gene expression; Synbiotics; β-glucan}},
  language     = {{eng}},
  month        = {{05}},
  pages        = {{12--23}},
  publisher    = {{Elsevier}},
  series       = {{Journal of Functional Foods}},
  title        = {{Combinations of cereal β-glucans and probiotics can enhance the anti-inflammatory activity on host cells by a synergistic effect}},
  url          = {{http://dx.doi.org/10.1016/j.jff.2016.02.015}},
  doi          = {{10.1016/j.jff.2016.02.015}},
  volume       = {{23}},
  year         = {{2016}},
}