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Correlations between cholinergic neurons and muscarinic m2 receptors in the rat retina

Wassélius, J LU ; Johansson, Kjell LU ; Bruun, A LU ; Zucker, C and Ehinger, B LU (1998) In NeuroReport 9(8). p.802-1799
Abstract

Acetylcholine is well established as the neurotransmitter of starburst amacrine cells in the vertebrate retina but their function is poorly understood. We compared the distribution of muscarinic m2 receptors in the rat retina with the localization of the starburst cell processes. mAChR2 immunoreactivity appeared in a central band in the inner plexiform layer, which did not co-localize with the processes of the cholinergic amacrine cells. We found co-labelling of VAChT and ChAT making it highly unlikely that there are undetected cholinergic neurons in rat retina. Most mAChR2 receptors were located far from the cholinergic neurons, suggesting that most of them are unlikely to be associated with conventional cholinergic synapses.

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organization
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type
Contribution to journal
publication status
published
subject
keywords
Acetylcholine, Animals, Choline O-Acetyltransferase, Female, Neurons, Rats, Rats, Sprague-Dawley, Receptors, Muscarinic, Retina, Comparative Study, Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.
in
NeuroReport
volume
9
issue
8
pages
4 pages
publisher
Lippincott Williams & Wilkins
external identifiers
  • Scopus:0032104066
ISSN
0959-4965
language
English
LU publication?
yes
id
385e00c5-f536-4305-b1e6-1f4dd1b61498
date added to LUP
2016-10-14 10:02:03
date last changed
2016-10-17 10:32:06
@misc{385e00c5-f536-4305-b1e6-1f4dd1b61498,
  abstract     = {<p>Acetylcholine is well established as the neurotransmitter of starburst amacrine cells in the vertebrate retina but their function is poorly understood. We compared the distribution of muscarinic m2 receptors in the rat retina with the localization of the starburst cell processes. mAChR2 immunoreactivity appeared in a central band in the inner plexiform layer, which did not co-localize with the processes of the cholinergic amacrine cells. We found co-labelling of VAChT and ChAT making it highly unlikely that there are undetected cholinergic neurons in rat retina. Most mAChR2 receptors were located far from the cholinergic neurons, suggesting that most of them are unlikely to be associated with conventional cholinergic synapses.</p>},
  author       = {Wassélius, J and Johansson, Kjell and Bruun, A and Zucker, C and Ehinger, B},
  issn         = {0959-4965},
  keyword      = {Acetylcholine,Animals,Choline O-Acetyltransferase,Female,Neurons,Rats,Rats, Sprague-Dawley,Receptors, Muscarinic,Retina,Comparative Study,Journal Article,Research Support, Non-U.S. Gov't,Research Support, U.S. Gov't, P.H.S.},
  language     = {eng},
  month        = {06},
  number       = {8},
  pages        = {802--1799},
  publisher    = {ARRAY(0xc72b168)},
  series       = {NeuroReport},
  title        = {Correlations between cholinergic neurons and muscarinic m2 receptors in the rat retina},
  volume       = {9},
  year         = {1998},
}