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Characterization of the gene for prostate-specific antigen, a human glandular kallikrein

Lundwall, Åke LU (1989) In Biochem Biophys Res Commun 161(3). p.1151-9
Abstract
The gene for the human glandular kallikrein, prostate-specific antigen, has been cloned. The sequence of 7130 nucleotides encompassing the gene and 633 bp of 5' and 639 bp of 3' flanking DNA has been determined. The translation initiation site was slightly heterogeneous, yielding 5' non-translated leader sequences of 41 and 35 bp. The gene is divided into five exons, with introns located at positions identical with those found in other glandular kallikrein genes. The nucleotide sequence is very similar to that of the human kallikrein gene hGK-1, with 76 to 93% of the nucleotides being identical in the exons and 76 to 87% in the introns. The similarity also extends approximately 200 bp into the sequence flanking the 5' end of hGK-1 and... (More)
The gene for the human glandular kallikrein, prostate-specific antigen, has been cloned. The sequence of 7130 nucleotides encompassing the gene and 633 bp of 5' and 639 bp of 3' flanking DNA has been determined. The translation initiation site was slightly heterogeneous, yielding 5' non-translated leader sequences of 41 and 35 bp. The gene is divided into five exons, with introns located at positions identical with those found in other glandular kallikrein genes. The nucleotide sequence is very similar to that of the human kallikrein gene hGK-1, with 76 to 93% of the nucleotides being identical in the exons and 76 to 87% in the introns. The similarity also extends approximately 200 bp into the sequence flanking the 5' end of hGK-1 and several other, both human and rodent, glandular kallikrein genes. (Less)
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published
subject
keywords
Prostate-Specific Antigen, Prostate/*immunology, Molecular Sequence Data, Male, Kallikreins/*genetics, Introns, Humans, *Genes, Exons, Molecular, Cloning, Base Sequence, Amino Acid Sequence, Neoplasm/*genetics, Antigens, RNA Caps/genetics, Repetitive Sequences, Nucleic Acid, Research Support, Non-U.S. Gov't, Restriction Mapping, Tissue Kallikreins
in
Biochem Biophys Res Commun
volume
161
issue
3
pages
1151 - 9
external identifiers
  • Scopus:0024333883
language
English
LU publication?
yes
id
417147be-cfe5-4cbe-8aa8-110a0b2f50ff (old id 3965178)
alternative location
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=2472789
date added to LUP
2013-08-11 15:07:55
date last changed
2016-04-16 12:47:51
@misc{417147be-cfe5-4cbe-8aa8-110a0b2f50ff,
  abstract     = {The gene for the human glandular kallikrein, prostate-specific antigen, has been cloned. The sequence of 7130 nucleotides encompassing the gene and 633 bp of 5' and 639 bp of 3' flanking DNA has been determined. The translation initiation site was slightly heterogeneous, yielding 5' non-translated leader sequences of 41 and 35 bp. The gene is divided into five exons, with introns located at positions identical with those found in other glandular kallikrein genes. The nucleotide sequence is very similar to that of the human kallikrein gene hGK-1, with 76 to 93% of the nucleotides being identical in the exons and 76 to 87% in the introns. The similarity also extends approximately 200 bp into the sequence flanking the 5' end of hGK-1 and several other, both human and rodent, glandular kallikrein genes.},
  author       = {Lundwall, Åke},
  keyword      = {Prostate-Specific Antigen,Prostate/*immunology,Molecular Sequence Data,Male,Kallikreins/*genetics,Introns,Humans,*Genes,Exons,Molecular,Cloning,Base Sequence,Amino Acid Sequence,Neoplasm/*genetics,Antigens,RNA Caps/genetics,Repetitive Sequences,Nucleic Acid,Research Support,Non-U.S. Gov't,Restriction Mapping,Tissue Kallikreins},
  language     = {eng},
  number       = {3},
  pages        = {1151--9},
  series       = {Biochem Biophys Res Commun},
  title        = {Characterization of the gene for prostate-specific antigen, a human glandular kallikrein},
  volume       = {161},
  year         = {1989},
}