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The nonhemostatic immune functions of platelets

Kapur, Rick and Semple, John W LU (2016) In Seminars in Hematology 53(Suppl 1). p.2-6
Abstract

Platelets are megakaryocyte-derived cellular fragments, which lack a nucleus and are the smallest circulating cells and are classically known to have a major role in supporting hemostasis. Apart from this well-established role, it is now becoming evident that platelets are also capable of conveying other important functions, such as during infection and inflammation. This paper will outline these nonhemostatic functions in two major sections termed "Platelets versus pathogens" and "Platelet-target cell communication". Platelets actively contribute to protection against invading pathogens and are capable of regulating immune functions in various target cells, all through sophisticated and efficient mechanisms. These relatively novel... (More)

Platelets are megakaryocyte-derived cellular fragments, which lack a nucleus and are the smallest circulating cells and are classically known to have a major role in supporting hemostasis. Apart from this well-established role, it is now becoming evident that platelets are also capable of conveying other important functions, such as during infection and inflammation. This paper will outline these nonhemostatic functions in two major sections termed "Platelets versus pathogens" and "Platelet-target cell communication". Platelets actively contribute to protection against invading pathogens and are capable of regulating immune functions in various target cells, all through sophisticated and efficient mechanisms. These relatively novel features will be highlighted, illustrating the multifunctional role of platelets in inflammation.

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Please use this url to cite or link to this publication:
author
publishing date
type
Contribution to journal
publication status
published
keywords
Journal Article
in
Seminars in Hematology
volume
53
issue
Suppl 1
pages
2 - 6
publisher
Elsevier
external identifiers
  • Scopus:84973908633
ISSN
0037-1963
DOI
10.1053/j.seminhematol.2016.04.002
language
English
LU publication?
no
id
3e1d1f23-8d1e-4621-bdc5-4f11b2bb6bf2
date added to LUP
2016-09-23 11:55:21
date last changed
2016-10-13 05:14:10
@misc{3e1d1f23-8d1e-4621-bdc5-4f11b2bb6bf2,
  abstract     = {<p>Platelets are megakaryocyte-derived cellular fragments, which lack a nucleus and are the smallest circulating cells and are classically known to have a major role in supporting hemostasis. Apart from this well-established role, it is now becoming evident that platelets are also capable of conveying other important functions, such as during infection and inflammation. This paper will outline these nonhemostatic functions in two major sections termed "Platelets versus pathogens" and "Platelet-target cell communication". Platelets actively contribute to protection against invading pathogens and are capable of regulating immune functions in various target cells, all through sophisticated and efficient mechanisms. These relatively novel features will be highlighted, illustrating the multifunctional role of platelets in inflammation.</p>},
  author       = {Kapur, Rick and Semple, John W},
  issn         = {0037-1963},
  keyword      = {Journal Article},
  language     = {eng},
  number       = {Suppl 1},
  pages        = {2--6},
  publisher    = {ARRAY(0x9b38c68)},
  series       = {Seminars in Hematology},
  title        = {The nonhemostatic immune functions of platelets},
  url          = {http://dx.doi.org/10.1053/j.seminhematol.2016.04.002},
  volume       = {53},
  year         = {2016},
}