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Role of Monocytes and Intestinal Macrophages in Crohn's Disease and Ulcerative Colitis

Grip, Olof LU (2016) In Inflammatory Bowel Diseases 22(8). p.1992-1998
Abstract

Monocytes and macrophages are part of the body's first line of defence, eliminating pathogens by phagocytosis or by releasing a broad array of inflammatory mediators, such as cytokines, chemokines, and proteases. In humans, 3 subsets of monocytes are described in blood with seemingly different functions, the classical (CD14 + + CD16 -) monocytes, the intermediate (CD14 + + CD16 +) monocytes, and the nonclassical (CD14 + CD16 + +) monocytes. In the intestine, macrophages can be divided into resident and inflammatory macrophages that are distinguished by low and high expression of CD14, respectively. However, the roles and function of the 3 monocyte... (More)

Monocytes and macrophages are part of the body's first line of defence, eliminating pathogens by phagocytosis or by releasing a broad array of inflammatory mediators, such as cytokines, chemokines, and proteases. In humans, 3 subsets of monocytes are described in blood with seemingly different functions, the classical (CD14 + + CD16 -) monocytes, the intermediate (CD14 + + CD16 +) monocytes, and the nonclassical (CD14 + CD16 + +) monocytes. In the intestine, macrophages can be divided into resident and inflammatory macrophages that are distinguished by low and high expression of CD14, respectively. However, the roles and function of the 3 monocyte subsets in health and disease are not fully understood. In this review, we describe what is known about the origin of human intestinal macrophages and their blood monocytic counterparts and many of their numerous distinct mechanisms influencing the intestinal immune system.

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Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
cytokines, IBD, intestinal inflammation, macrophages, monocytes
in
Inflammatory Bowel Diseases
volume
22
issue
8
pages
7 pages
publisher
John Wiley & Sons
external identifiers
  • Scopus:84979871450
ISSN
1078-0998
DOI
10.1097/MIB.0000000000000824
language
English
LU publication?
yes
id
456f8b89-9b8b-412a-846d-e144e2f475da
date added to LUP
2016-09-08 15:14:40
date last changed
2016-09-08 15:14:40
@misc{456f8b89-9b8b-412a-846d-e144e2f475da,
  abstract     = {<p>Monocytes and macrophages are part of the body's first line of defence, eliminating pathogens by phagocytosis or by releasing a broad array of inflammatory mediators, such as cytokines, chemokines, and proteases. In humans, 3 subsets of monocytes are described in blood with seemingly different functions, the classical (CD14 <sup>+</sup> <sup>+</sup> CD16 -) monocytes, the intermediate (CD14 <sup>+</sup> <sup>+</sup> CD16 <sup>+</sup>) monocytes, and the nonclassical (CD14 <sup>+</sup> CD16 <sup>+</sup> <sup>+</sup>) monocytes. In the intestine, macrophages can be divided into resident and inflammatory macrophages that are distinguished by low and high expression of CD14, respectively. However, the roles and function of the 3 monocyte subsets in health and disease are not fully understood. In this review, we describe what is known about the origin of human intestinal macrophages and their blood monocytic counterparts and many of their numerous distinct mechanisms influencing the intestinal immune system.</p>},
  author       = {Grip, Olof},
  issn         = {1078-0998},
  keyword      = {cytokines,IBD,intestinal inflammation,macrophages,monocytes},
  language     = {eng},
  month        = {05},
  number       = {8},
  pages        = {1992--1998},
  publisher    = {ARRAY(0x9f1d030)},
  series       = {Inflammatory Bowel Diseases},
  title        = {Role of Monocytes and Intestinal Macrophages in Crohn's Disease and Ulcerative Colitis},
  url          = {http://dx.doi.org/10.1097/MIB.0000000000000824},
  volume       = {22},
  year         = {2016},
}