Advanced

Criteria for the Research Institute for Fragrance Materials, Inc. (RIFM) safety evaluation process for fragrance ingredients.

Api, A M; Belsito, D; Bruze, Magnus LU ; Cadby, P; Calow, P; Dagli, M L; Dekant, W; Dent, M; Ellis, G and Fryer, A D, et al. (2014) In Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
Abstract
The Research Institute for Fragrance Materials, Inc. (RIFM) has been engaged in the generation and evaluation of safety data for fragrance materials since its inception over 45 years ago. Over time, RIFM's approach to gathering data, estimating exposure and assessing safety has evolved as the tools for risk assessment evolved. This publication is designed to update the RIFM safety assessment process, which follows a series of decision trees, reflecting advances in approaches in risk assessment and new and classical toxicological methodologies employed by RIFM over the past ten years. These changes include incorporating 1) new scientific information including a framework for choosing structural analogs, 2) consideration of the Threshold of... (More)
The Research Institute for Fragrance Materials, Inc. (RIFM) has been engaged in the generation and evaluation of safety data for fragrance materials since its inception over 45 years ago. Over time, RIFM's approach to gathering data, estimating exposure and assessing safety has evolved as the tools for risk assessment evolved. This publication is designed to update the RIFM safety assessment process, which follows a series of decision trees, reflecting advances in approaches in risk assessment and new and classical toxicological methodologies employed by RIFM over the past ten years. These changes include incorporating 1) new scientific information including a framework for choosing structural analogs, 2) consideration of the Threshold of Toxicological Concern (TTC), 3) the Quantitative Risk Assessment (QRA) for dermal contact sensitization, 4) the respiratory route of exposure, 5) aggregate exposure assessment methodology, 6) the latest methodology and approaches to risk assessments, 7) the latest alternatives to animal testing methodology and 8) environmental risk assessment. The assessment begins with a thorough analysis of existing data followed by in silico analysis, identification of 'read across' analogs, generation of additional data through in vitro testing as well as consideration of the TTC approach. If necessary, risk management may be considered. (Less)
Please use this url to cite or link to this publication:
author
, et al. (More)
(Less)
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
publisher
Elsevier
external identifiers
  • PMID:25510979
  • Scopus:84934443891
ISSN
1873-6351
DOI
10.1016/j.fct.2014.11.014
language
English
LU publication?
yes
id
b89e8ef1-aacf-4c59-bede-fa1f91ae6fe9 (old id 4908204)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/25510979?dopt=Abstract
date added to LUP
2015-01-07 17:19:22
date last changed
2016-12-04 04:39:22
@misc{b89e8ef1-aacf-4c59-bede-fa1f91ae6fe9,
  abstract     = {The Research Institute for Fragrance Materials, Inc. (RIFM) has been engaged in the generation and evaluation of safety data for fragrance materials since its inception over 45 years ago. Over time, RIFM's approach to gathering data, estimating exposure and assessing safety has evolved as the tools for risk assessment evolved. This publication is designed to update the RIFM safety assessment process, which follows a series of decision trees, reflecting advances in approaches in risk assessment and new and classical toxicological methodologies employed by RIFM over the past ten years. These changes include incorporating 1) new scientific information including a framework for choosing structural analogs, 2) consideration of the Threshold of Toxicological Concern (TTC), 3) the Quantitative Risk Assessment (QRA) for dermal contact sensitization, 4) the respiratory route of exposure, 5) aggregate exposure assessment methodology, 6) the latest methodology and approaches to risk assessments, 7) the latest alternatives to animal testing methodology and 8) environmental risk assessment. The assessment begins with a thorough analysis of existing data followed by in silico analysis, identification of 'read across' analogs, generation of additional data through in vitro testing as well as consideration of the TTC approach. If necessary, risk management may be considered.},
  author       = {Api, A M and Belsito, D and Bruze, Magnus and Cadby, P and Calow, P and Dagli, M L and Dekant, W and Dent, M and Ellis, G and Fryer, A D and Fukayama, M and Griem, P and Hickey, C and Kromidas, L and Lalko, J F and Liebler, D C and Miyachi, Y and Politano, V T and Renskers, K and Ritacco, G and Salvito, D and Schultz, T W and Sipes, I G and Smith, B and Vitale, D and Wilcox, D K},
  issn         = {1873-6351},
  language     = {eng},
  publisher    = {ARRAY(0xaf64a08)},
  series       = {Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association},
  title        = {Criteria for the Research Institute for Fragrance Materials, Inc. (RIFM) safety evaluation process for fragrance ingredients.},
  url          = {http://dx.doi.org/10.1016/j.fct.2014.11.014},
  year         = {2014},
}