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Sensitivity of mongolian gerbils to trichloroethylene exposure during neonatal growth

Kjellstrand, Per; Månsson, Lennart; Bjerkemo, M; Lanke, Jan LU ; Holmquist, Björn LU and Zetterqvist, Lena LU (1982) In Toxicology Letters 14(1-2). p.97-101
Abstract
Continuous exposure of young mongolian gerbils to trichloroethylene (230 ppm) was started at different times during the first month of life. The onset of exposure was accompanied by an increased number of deaths among the pups and by an immediate reduction in growth rate. The proportion of dead pups was greatest when exposure was started at birth, and decreased rapidly with increasing age at onset of exposure. Growth rate was partially restored approx. 1 week after the onset of exposure. After weaning the effect of the exposure on growth decreased, and the variation in the effect among different litters was considerably reduced. The enhanced sensitivity of the pups to trichloroethylene (TCE) exposure is believed to be due to a disturbance... (More)
Continuous exposure of young mongolian gerbils to trichloroethylene (230 ppm) was started at different times during the first month of life. The onset of exposure was accompanied by an increased number of deaths among the pups and by an immediate reduction in growth rate. The proportion of dead pups was greatest when exposure was started at birth, and decreased rapidly with increasing age at onset of exposure. Growth rate was partially restored approx. 1 week after the onset of exposure. After weaning the effect of the exposure on growth decreased, and the variation in the effect among different litters was considerably reduced. The enhanced sensitivity of the pups to trichloroethylene (TCE) exposure is believed to be due to a disturbance in the mother-offspring relationship. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Mongolian gerbil, trichloroethylene, Meriones unguiculatus, neonatal, growth
in
Toxicology Letters
volume
14
issue
1-2
pages
97 - 101
publisher
Elsevier
external identifiers
  • Scopus:0020422239
ISSN
1879-3169
DOI
10.1016/0378-4274(82)90015-7
language
English
LU publication?
yes
id
cc7d58a0-e51d-4663-b517-a4ab45c88ab2 (old id 4934726)
date added to LUP
2015-01-22 13:12:30
date last changed
2016-10-13 04:47:46
@misc{cc7d58a0-e51d-4663-b517-a4ab45c88ab2,
  abstract     = {Continuous exposure of young mongolian gerbils to trichloroethylene (230 ppm) was started at different times during the first month of life. The onset of exposure was accompanied by an increased number of deaths among the pups and by an immediate reduction in growth rate. The proportion of dead pups was greatest when exposure was started at birth, and decreased rapidly with increasing age at onset of exposure. Growth rate was partially restored approx. 1 week after the onset of exposure. After weaning the effect of the exposure on growth decreased, and the variation in the effect among different litters was considerably reduced. The enhanced sensitivity of the pups to trichloroethylene (TCE) exposure is believed to be due to a disturbance in the mother-offspring relationship.},
  author       = {Kjellstrand, Per and Månsson, Lennart and Bjerkemo, M and Lanke, Jan and Holmquist, Björn and Zetterqvist, Lena},
  issn         = {1879-3169},
  keyword      = {Mongolian gerbil,trichloroethylene,Meriones unguiculatus,neonatal,growth},
  language     = {eng},
  number       = {1-2},
  pages        = {97--101},
  publisher    = {ARRAY(0x9df0060)},
  series       = {Toxicology Letters},
  title        = {Sensitivity of mongolian gerbils to trichloroethylene exposure during neonatal growth},
  url          = {http://dx.doi.org/10.1016/0378-4274(82)90015-7},
  volume       = {14},
  year         = {1982},
}