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Hepatosplenic candidiasis after neutropenic phase of acute leukaemia

Colović, M; LAZAREVIC, VLADIMIR LU ; Colović, R; Janković, G; Suvajdzić, N; Bogdanović, A and Bila, J (1999) In Medical Oncology 16(2). p.42-139
Abstract

Hepatosplenic candidiasis following granulocytopenic periods is a relatively recently recognised problem in immunocompromised patients, particularly in those with acute leukaemia. We present three patients in whom diagnosis of hepatosplenic candidiasis was suspected on the basis of ultrasonographic (US), computed tomographic (CT) findings and confirmed by laparoscopy and biopsy of liver lesions. All three patients were successfully treated briefly with amphotericin B, followed by a longer period of fluconazole. In one patient laparotomy and surgical evacuation of abscesses was performed. This condition could be more often recognised by careful follow-up of liver function test, C-reactive protein level, ultrasonography, CT and MRI after... (More)

Hepatosplenic candidiasis following granulocytopenic periods is a relatively recently recognised problem in immunocompromised patients, particularly in those with acute leukaemia. We present three patients in whom diagnosis of hepatosplenic candidiasis was suspected on the basis of ultrasonographic (US), computed tomographic (CT) findings and confirmed by laparoscopy and biopsy of liver lesions. All three patients were successfully treated briefly with amphotericin B, followed by a longer period of fluconazole. In one patient laparotomy and surgical evacuation of abscesses was performed. This condition could be more often recognised by careful follow-up of liver function test, C-reactive protein level, ultrasonography, CT and MRI after recovery from chemotherapy-induced neutropenia.

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author
publishing date
type
Contribution to journal
publication status
published
keywords
Adult, Amphotericin B, Antifungal Agents, Antineoplastic Combined Chemotherapy Protocols, Candidiasis, Female, Fluconazole, Humans, Leukemia, Monocytic, Acute, Leukemia, Myeloid, Acute, Leukemia-Lymphoma, Adult T-Cell, Liver Diseases, Male, Middle Aged, Neutropenia, Opportunistic Infections, Splenic Diseases
in
Medical Oncology
volume
16
issue
2
pages
4 pages
publisher
Humana Press
external identifiers
  • Scopus:0032814026
ISSN
1357-0560
language
English
LU publication?
no
id
4d2560ea-5dc6-4983-a2d1-fcb637669742
date added to LUP
2016-05-24 17:25:54
date last changed
2016-10-13 05:09:25
@misc{4d2560ea-5dc6-4983-a2d1-fcb637669742,
  abstract     = {<p>Hepatosplenic candidiasis following granulocytopenic periods is a relatively recently recognised problem in immunocompromised patients, particularly in those with acute leukaemia. We present three patients in whom diagnosis of hepatosplenic candidiasis was suspected on the basis of ultrasonographic (US), computed tomographic (CT) findings and confirmed by laparoscopy and biopsy of liver lesions. All three patients were successfully treated briefly with amphotericin B, followed by a longer period of fluconazole. In one patient laparotomy and surgical evacuation of abscesses was performed. This condition could be more often recognised by careful follow-up of liver function test, C-reactive protein level, ultrasonography, CT and MRI after recovery from chemotherapy-induced neutropenia.</p>},
  author       = {Colović, M and LAZAREVIC, VLADIMIR and Colović, R and Janković, G and Suvajdzić, N and Bogdanović, A and Bila, J},
  issn         = {1357-0560},
  keyword      = {Adult,Amphotericin B,Antifungal Agents,Antineoplastic Combined Chemotherapy Protocols,Candidiasis,Female,Fluconazole,Humans,Leukemia, Monocytic, Acute,Leukemia, Myeloid, Acute,Leukemia-Lymphoma, Adult T-Cell,Liver Diseases,Male,Middle Aged,Neutropenia,Opportunistic Infections,Splenic Diseases},
  language     = {eng},
  number       = {2},
  pages        = {42--139},
  publisher    = {ARRAY(0x9da8aa0)},
  series       = {Medical Oncology},
  title        = {Hepatosplenic candidiasis after neutropenic phase of acute leukaemia},
  volume       = {16},
  year         = {1999},
}