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Growth and risk for islet autoimmunity and progression to type 1 diabetes in early childhood : The environmental determinants of diabetes in the young study

Larsson, Helena Elding LU ; Vehik, Kendra LU ; Haller, Michael J.; Liu, Xiang; Akolkar, Beena; Hagopian, William; Krischer, Jeffrey; Lernmark, Åke LU ; She, Jin Xiong and Simell, Olli, et al. (2016) In Diabetes 65(7). p.1988-1995
Abstract

Increased growth in early childhood has been suggested to increase the risk of type 1 diabetes. This study explored the relationship between weight or height and development of persistent islet autoimmunity and progression to type 1 diabetes during the first 4 years of life in 7,468 children at genetic risk for type 1 diabetes followed in Finland, Germany, Sweden, and the U.S. Growth data collected every third month were used to estimate individual growth curves by mixed models. Cox proportional hazards models were used to evaluate body size and risk of islet autoimmunity and type 1 diabetes. In the overall cohort, development of islet autoimmunity (n = 575) was related to weight z scores at 12 months (hazard ratio [HR] 1.16 per 1.14 kg... (More)

Increased growth in early childhood has been suggested to increase the risk of type 1 diabetes. This study explored the relationship between weight or height and development of persistent islet autoimmunity and progression to type 1 diabetes during the first 4 years of life in 7,468 children at genetic risk for type 1 diabetes followed in Finland, Germany, Sweden, and the U.S. Growth data collected every third month were used to estimate individual growth curves by mixed models. Cox proportional hazards models were used to evaluate body size and risk of islet autoimmunity and type 1 diabetes. In the overall cohort, development of islet autoimmunity (n = 575) was related to weight z scores at 12 months (hazard ratio [HR] 1.16 per 1.14 kg in males or per 1.02 kg in females, 95% CI 1.06-1.27, P <0.001, false discovery rate [FDR] = 0.008) but not at 24 or 36 months. A similar relationship was seen between weight z scores and development of multiple islet autoantibodies (1 year: HR 1.21, 95% CI 1.08-1.35, P = 0.001, FDR = 0.008; 2 years: HR 1.18, 95% CI 1.06-1.32, P = 0.004, FDR = 0.02). No association was found between weight or height and type 1 diabetes (n = 169). In conclusion, greater weight in the first years of life was associated with an increased risk of islet autoimmunity.

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organization
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type
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publication status
published
subject
in
Diabetes
volume
65
issue
7
pages
8 pages
publisher
American Diabetes Association
external identifiers
  • Scopus:84975797049
ISSN
0012-1797
DOI
10.2337/db15-1180
language
English
LU publication?
yes
id
4d59b7d8-00a9-4d38-90a6-d6cd5e61accf
date added to LUP
2016-07-19 13:37:05
date last changed
2016-10-31 09:49:34
@misc{4d59b7d8-00a9-4d38-90a6-d6cd5e61accf,
  abstract     = {<p>Increased growth in early childhood has been suggested to increase the risk of type 1 diabetes. This study explored the relationship between weight or height and development of persistent islet autoimmunity and progression to type 1 diabetes during the first 4 years of life in 7,468 children at genetic risk for type 1 diabetes followed in Finland, Germany, Sweden, and the U.S. Growth data collected every third month were used to estimate individual growth curves by mixed models. Cox proportional hazards models were used to evaluate body size and risk of islet autoimmunity and type 1 diabetes. In the overall cohort, development of islet autoimmunity (n = 575) was related to weight z scores at 12 months (hazard ratio [HR] 1.16 per 1.14 kg in males or per 1.02 kg in females, 95% CI 1.06-1.27, P &lt;0.001, false discovery rate [FDR] = 0.008) but not at 24 or 36 months. A similar relationship was seen between weight z scores and development of multiple islet autoantibodies (1 year: HR 1.21, 95% CI 1.08-1.35, P = 0.001, FDR = 0.008; 2 years: HR 1.18, 95% CI 1.06-1.32, P = 0.004, FDR = 0.02). No association was found between weight or height and type 1 diabetes (n = 169). In conclusion, greater weight in the first years of life was associated with an increased risk of islet autoimmunity.</p>},
  author       = {Larsson, Helena Elding and Vehik, Kendra and Haller, Michael J. and Liu, Xiang and Akolkar, Beena and Hagopian, William and Krischer, Jeffrey and Lernmark, Åke and She, Jin Xiong and Simell, Olli and Toppari, Jorma and Ziegler, Anette G. and Rewers, Marian},
  issn         = {0012-1797},
  language     = {eng},
  month        = {07},
  number       = {7},
  pages        = {1988--1995},
  publisher    = {ARRAY(0xafdc6d8)},
  series       = {Diabetes},
  title        = {Growth and risk for islet autoimmunity and progression to type 1 diabetes in early childhood : The environmental determinants of diabetes in the young study},
  url          = {http://dx.doi.org/10.2337/db15-1180},
  volume       = {65},
  year         = {2016},
}