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Gender-specific incidence of autoimmune diseases from national registers

Ji, Jianguang LU ; Sundquist, Jan LU and Sundquist, Kristina LU (2016) In Journal of Autoimmunity 69. p.6-102
Abstract

BACKGROUND: It is widely believed that autoimmune diseases affect predominantly in women, but the available evidence came from case control study with potential selection and recall bias. We aimed to examine the gender-specific incidence of autoimmune diseases by using national wide registers in Sweden.

METHODS: Swedish Hospital Discharge Register and Outpatient Register were used to identify a set of autoimmune diseases between 1987 and 2010. Gender-specific incidence rate was standardized directly according to the Swedish age distribution in 2000.

RESULTS: A total of 403,757 individuals were diagnosed with autoimmune diseases between 1987 and 2010 in Sweden. The overall incidence of 32 autoimmune disease was 60% higher in... (More)

BACKGROUND: It is widely believed that autoimmune diseases affect predominantly in women, but the available evidence came from case control study with potential selection and recall bias. We aimed to examine the gender-specific incidence of autoimmune diseases by using national wide registers in Sweden.

METHODS: Swedish Hospital Discharge Register and Outpatient Register were used to identify a set of autoimmune diseases between 1987 and 2010. Gender-specific incidence rate was standardized directly according to the Swedish age distribution in 2000.

RESULTS: A total of 403,757 individuals were diagnosed with autoimmune diseases between 1987 and 2010 in Sweden. The overall incidence of 32 autoimmune disease was 60% higher in women than men. Female predominance was noted in 18 specific diseases, whereas the rest of them showed no difference or male predominance. The age of onset was different between men and women in 27 autoimmune diseases.

CONCLUSIONS: Our study suggested that the classical view of female predominance of autoimmune diseases may be far from striking than previously believed. Further studies are needed to examine whether there is true difference between men and women.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Autoimmunity
volume
69
pages
5 pages
publisher
Elsevier
external identifiers
  • Scopus:84961195626
ISSN
0896-8411
DOI
10.1016/j.jaut.2016.03.003
language
English
LU publication?
yes
id
525ccf28-b388-4c93-905b-a9455c55bc49
date added to LUP
2016-04-13 08:52:27
date last changed
2016-12-04 04:50:25
@misc{525ccf28-b388-4c93-905b-a9455c55bc49,
  abstract     = {<p>BACKGROUND: It is widely believed that autoimmune diseases affect predominantly in women, but the available evidence came from case control study with potential selection and recall bias. We aimed to examine the gender-specific incidence of autoimmune diseases by using national wide registers in Sweden.</p><p>METHODS: Swedish Hospital Discharge Register and Outpatient Register were used to identify a set of autoimmune diseases between 1987 and 2010. Gender-specific incidence rate was standardized directly according to the Swedish age distribution in 2000.</p><p>RESULTS: A total of 403,757 individuals were diagnosed with autoimmune diseases between 1987 and 2010 in Sweden. The overall incidence of 32 autoimmune disease was 60% higher in women than men. Female predominance was noted in 18 specific diseases, whereas the rest of them showed no difference or male predominance. The age of onset was different between men and women in 27 autoimmune diseases.</p><p>CONCLUSIONS: Our study suggested that the classical view of female predominance of autoimmune diseases may be far from striking than previously believed. Further studies are needed to examine whether there is true difference between men and women.</p>},
  author       = {Ji, Jianguang and Sundquist, Jan and Sundquist, Kristina},
  issn         = {0896-8411},
  language     = {eng},
  pages        = {6--102},
  publisher    = {ARRAY(0xbf546d8)},
  series       = {Journal of Autoimmunity},
  title        = {Gender-specific incidence of autoimmune diseases from national registers},
  url          = {http://dx.doi.org/10.1016/j.jaut.2016.03.003},
  volume       = {69},
  year         = {2016},
}