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Increased levels of proteoglycan fragments in knee joint fluid after injury

Lohmander, Stefan LU ; Dahlberg, Leif LU ; Ryd, Leif LU and Heinegård, Dick LU (1989) In Arthritis and Rheumatism 32(11). p.1434-1442
Abstract

We measured the levels of cartilage proteoglycan (PG) fragments in knee joint synovial fluid obtained from patients with previous trauma of the knee, early gonarthrosis, or pyrophosphate synovitis, and in age-matched control subjects. During the initial 3-4 weeks after rupture of the anterior cruciate ligament or the meniscus (confirmed by arthroscopy), markedly increased PG fragment levels were found. At later times after trauma (up to 4 years), many of these patients still had significantly elevated levels of cartilage PG fragments in the joint fluid. In a group of older patients with gonarthrosis, these levels were only moderately elevated, while in patients with acute pseudogout, greatly increased levels were observed. Although... (More)

We measured the levels of cartilage proteoglycan (PG) fragments in knee joint synovial fluid obtained from patients with previous trauma of the knee, early gonarthrosis, or pyrophosphate synovitis, and in age-matched control subjects. During the initial 3-4 weeks after rupture of the anterior cruciate ligament or the meniscus (confirmed by arthroscopy), markedly increased PG fragment levels were found. At later times after trauma (up to 4 years), many of these patients still had significantly elevated levels of cartilage PG fragments in the joint fluid. In a group of older patients with gonarthrosis, these levels were only moderately elevated, while in patients with acute pseudogout, greatly increased levels were observed. Although longitudinal studies are needed to validate the significance, PG fragments in joint fluid may be a marker for early posttraumatic arthrosis.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Arthritis and Rheumatism
volume
32
issue
11
pages
9 pages
publisher
John Wiley & Sons
external identifiers
  • Scopus:0024352667
ISSN
0004-3591
DOI
10.1002/anr.1780321113
language
English
LU publication?
yes
id
581f99e7-1fc6-4c0b-85ca-03516b59d4bf
date added to LUP
2016-05-04 18:13:32
date last changed
2016-07-04 12:19:15
@misc{581f99e7-1fc6-4c0b-85ca-03516b59d4bf,
  abstract     = {<p>We measured the levels of cartilage proteoglycan (PG) fragments in knee joint synovial fluid obtained from patients with previous trauma of the knee, early gonarthrosis, or pyrophosphate synovitis, and in age-matched control subjects. During the initial 3-4 weeks after rupture of the anterior cruciate ligament or the meniscus (confirmed by arthroscopy), markedly increased PG fragment levels were found. At later times after trauma (up to 4 years), many of these patients still had significantly elevated levels of cartilage PG fragments in the joint fluid. In a group of older patients with gonarthrosis, these levels were only moderately elevated, while in patients with acute pseudogout, greatly increased levels were observed. Although longitudinal studies are needed to validate the significance, PG fragments in joint fluid may be a marker for early posttraumatic arthrosis.</p>},
  author       = {Lohmander, Stefan and Dahlberg, Leif and Ryd, Leif and Heinegård, Dick},
  issn         = {0004-3591},
  language     = {eng},
  number       = {11},
  pages        = {1434--1442},
  publisher    = {ARRAY(0x7a72948)},
  series       = {Arthritis and Rheumatism},
  title        = {Increased levels of proteoglycan fragments in knee joint fluid after injury},
  url          = {http://dx.doi.org/10.1002/anr.1780321113},
  volume       = {32},
  year         = {1989},
}