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Chronic cobalt exposure affects antioxidants and ATP production in rat myocardium

Clyne, N. LU ; Hofman-Bang, C.; Haga, Y.; Hatori, N.; Marklund, S. L.; Pehrsson, S. K. and Wibom, R. (2001) In Scandinavian Journal of Clinical & Laboratory Investigation 61(8). p.609-614
Abstract

Chronic cobalt exposure is characterized by severe cardiac insufficiency. Since the mechanisms of cobalt toxicity are not yet clear, we analysed the effects of chronic cobalt exposure on antioxidant enzyme activities and myocardial mitochondrial ATP production rate in a rat model. One group of rats was fed a conventional diet and another a cobalt supplemented diet for 24 weeks. The manganese-superoxide dismutase activity was markedly reduced in the cobalt rats (18±4.7 U/mg protein) compared to the control rats (100±22 U/mg protein; p

Please use this url to cite or link to this publication:
author
publishing date
type
Contribution to journal
publication status
published
keywords
ATP production rate, Chronic cobalt toxicity, Manganese-superoxide dismutase, Rat myocardium, Superoxide radicals
in
Scandinavian Journal of Clinical & Laboratory Investigation
volume
61
issue
8
pages
6 pages
publisher
Informa Healthcare
external identifiers
  • Scopus:0035193192
ISSN
0036-5513
DOI
10.1080/003655101753267964
language
English
LU publication?
no
id
6199c653-377d-481b-91e4-f9f03dfe0cab
date added to LUP
2016-08-30 21:53:01
date last changed
2016-09-16 15:09:52
@misc{6199c653-377d-481b-91e4-f9f03dfe0cab,
  abstract     = {<p>Chronic cobalt exposure is characterized by severe cardiac insufficiency. Since the mechanisms of cobalt toxicity are not yet clear, we analysed the effects of chronic cobalt exposure on antioxidant enzyme activities and myocardial mitochondrial ATP production rate in a rat model. One group of rats was fed a conventional diet and another a cobalt supplemented diet for 24 weeks. The manganese-superoxide dismutase activity was markedly reduced in the cobalt rats (18±4.7 U/mg protein) compared to the control rats (100±22 U/mg protein; p </p>},
  author       = {Clyne, N. and Hofman-Bang, C. and Haga, Y. and Hatori, N. and Marklund, S. L. and Pehrsson, S. K. and Wibom, R.},
  issn         = {0036-5513},
  keyword      = {ATP production rate,Chronic cobalt toxicity,Manganese-superoxide dismutase,Rat myocardium,Superoxide radicals},
  language     = {eng},
  number       = {8},
  pages        = {609--614},
  publisher    = {ARRAY(0x8684bf8)},
  series       = {Scandinavian Journal of Clinical & Laboratory Investigation},
  title        = {Chronic cobalt exposure affects antioxidants and ATP production in rat myocardium},
  url          = {http://dx.doi.org/10.1080/003655101753267964},
  volume       = {61},
  year         = {2001},
}