Advanced

Compounds for deactivating phospholamban function on Ca-ATPase (phospholamban inhibitors)

Pollesello, Piero; Ovaska, Martti; Tenhunen, J.; Vidgren, J.; Yliperttula, Marjo; Tilgmann, Carola LU ; Lotta, T. and Kaivola, Juha (2004) US 6774103 B1
Abstract
This invention relates to determining the three-dimensional structure of the cytosolic domain of phospholamban (PLB) and its active site from NMR data of sufficiently high resolution for the three-dimensional structure determination. The invention also relates to methods for rational drug design enabling the design of phospholamban inhibitors based on using the three-dimensional structure data provided on computer readable media, as analyzed on a computer system having suitable computer algorithms. The invention also relates to phospholamban inhibiting compounds with certain structural, physicochemical and spatial characteristics that allow for the interaction of said compounds with specific residues of the active site of phospholamban
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Patent
publication status
published
subject
keywords
calcium-ATPase, phospholamban, drug discovery
patent number
US 6774103 B1
language
English
LU publication?
yes
id
63d51c6e-a488-48a7-8758-a5e1b8640f1a
date added to LUP
2016-04-20 13:24:52
date last changed
2016-04-20 13:24:52
@misc{63d51c6e-a488-48a7-8758-a5e1b8640f1a,
  abstract     = {This invention relates to determining the three-dimensional structure of the cytosolic domain of phospholamban (PLB) and its active site from NMR data of sufficiently high resolution for the three-dimensional structure determination. The invention also relates to methods for rational drug design enabling the design of phospholamban inhibitors based on using the three-dimensional structure data provided on computer readable media, as analyzed on a computer system having suitable computer algorithms. The invention also relates to phospholamban inhibiting compounds with certain structural, physicochemical and spatial characteristics that allow for the interaction of said compounds with specific residues of the active site of phospholamban},
  author       = {Pollesello, Piero and Ovaska, Martti and Tenhunen, J. and Vidgren, J. and Yliperttula, Marjo and Tilgmann, Carola and Lotta, T. and Kaivola, Juha},
  keyword      = {calcium-ATPase,phospholamban,drug discovery},
  language     = {eng},
  month        = {08},
  title        = {Compounds for deactivating phospholamban function on Ca-ATPase (phospholamban inhibitors)},
  year         = {2004},
}