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High folate intake is associated with lower breast cancer incidence in postmenopausal women in the Malmö Diet and Cancer cohort

Ericson, Ulrika LU ; Sonestedt, Emily LU ; Gullberg, Bo LU ; Olsson, Håkan LU and Wirfält, Elisabet LU (2007) In American Journal of Clinical Nutrition 86(2). p.43-434
Abstract

BACKGROUND: Epidemiologic studies of associations between folate intake and breast cancer are inconclusive, but folate and other plant food nutrients appear protective in women at elevated risk.

OBJECTIVE: The objective was to examine the association between folate intake and the incidence of postmenopausal breast cancer.

DESIGN: This prospective study included all women aged >or=50 y (n = 11699) from the Malmö Diet and Cancer cohort. The mean follow-up time was 9.5 y. We used a modified diet-history method to collect nutrient intake data. At the end of follow-up, 392 incident invasive breast cancer cases were verified. We used proportional hazard regression to calculate hazard ratios (HRs).

RESULTS: Compared with... (More)

BACKGROUND: Epidemiologic studies of associations between folate intake and breast cancer are inconclusive, but folate and other plant food nutrients appear protective in women at elevated risk.

OBJECTIVE: The objective was to examine the association between folate intake and the incidence of postmenopausal breast cancer.

DESIGN: This prospective study included all women aged >or=50 y (n = 11699) from the Malmö Diet and Cancer cohort. The mean follow-up time was 9.5 y. We used a modified diet-history method to collect nutrient intake data. At the end of follow-up, 392 incident invasive breast cancer cases were verified. We used proportional hazard regression to calculate hazard ratios (HRs).

RESULTS: Compared with the lowest quintile, the incidence of invasive breast cancer was reduced in the highest quintile of dietary folate intake (HR: 0.56; 95% CI: 0.35, 0.90; P for trend = 0.02); total folate intake, including supplements (HR: 0.56; 95% CI: 0.34, 0.91; P for trend = 0.006); and dietary folate equivalents (HR: 0.59; 95% CI: 0.36, 0.97; P for trend = 0.01).

CONCLUSION: A high folate intake was associated with a lower incidence of postmenopausal breast cancer in this cohort.

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published
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keywords
Aged, Alcohol Drinking, Breast Neoplasms, Cohort Studies, Female, Folic Acid, Humans, Incidence, Leisure Activities, Middle Aged, Neoplasm Invasiveness, Postmenopause, Proportional Hazards Models, Smoking, Socioeconomic Factors, Sweden
in
American Journal of Clinical Nutrition
volume
86
issue
2
pages
10 pages
publisher
American Society for Clinical Nutrition
external identifiers
  • Scopus:34547884338
ISSN
0002-9165
language
English
LU publication?
yes
id
693c5be5-5623-49ed-b6c4-d80bea61f1e0
date added to LUP
2016-09-18 12:13:10
date last changed
2016-10-30 04:49:50
@misc{693c5be5-5623-49ed-b6c4-d80bea61f1e0,
  abstract     = {<p>BACKGROUND: Epidemiologic studies of associations between folate intake and breast cancer are inconclusive, but folate and other plant food nutrients appear protective in women at elevated risk.</p><p>OBJECTIVE: The objective was to examine the association between folate intake and the incidence of postmenopausal breast cancer.</p><p>DESIGN: This prospective study included all women aged &gt;or=50 y (n = 11699) from the Malmö Diet and Cancer cohort. The mean follow-up time was 9.5 y. We used a modified diet-history method to collect nutrient intake data. At the end of follow-up, 392 incident invasive breast cancer cases were verified. We used proportional hazard regression to calculate hazard ratios (HRs).</p><p>RESULTS: Compared with the lowest quintile, the incidence of invasive breast cancer was reduced in the highest quintile of dietary folate intake (HR: 0.56; 95% CI: 0.35, 0.90; P for trend = 0.02); total folate intake, including supplements (HR: 0.56; 95% CI: 0.34, 0.91; P for trend = 0.006); and dietary folate equivalents (HR: 0.59; 95% CI: 0.36, 0.97; P for trend = 0.01).</p><p>CONCLUSION: A high folate intake was associated with a lower incidence of postmenopausal breast cancer in this cohort.</p>},
  author       = {Ericson, Ulrika and Sonestedt, Emily and Gullberg, Bo and Olsson, Håkan and Wirfält, Elisabet},
  issn         = {0002-9165},
  keyword      = {Aged,Alcohol Drinking,Breast Neoplasms,Cohort Studies,Female,Folic Acid,Humans,Incidence,Leisure Activities,Middle Aged,Neoplasm Invasiveness,Postmenopause,Proportional Hazards Models,Smoking,Socioeconomic Factors,Sweden},
  language     = {eng},
  number       = {2},
  pages        = {43--434},
  publisher    = {ARRAY(0xa07b3c0)},
  series       = {American Journal of Clinical Nutrition},
  title        = {High folate intake is associated with lower breast cancer incidence in postmenopausal women in the Malmö Diet and Cancer cohort},
  volume       = {86},
  year         = {2007},
}