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Population genetics of the Malmö polymorphism of coagulation factor IX

Wallmark, Anders LU ; Kunkel, Glenna; Mouhli, Hassan; Bosco, John; Ljung, Rolf LU ; Nilsson, Inga Marie and Graham, John B. (1991) In Human Heredity 41(6). p.391-396
Abstract

The distribution of 1.198 Malmö alleles was examined in 822 men from 16 indigenous populations and 188 women from 7 of the ethnic groups. Subjects were from several European countries, the Mediterranean, East Asia, and the USA (Anglo- and African-Americans). The frequencies of the rarer (Malmö B) allele were approximately equal across Europe, the highest frequencies (0.36) being in the French and Anglo-Americans; no population was observed with clearly the highest frequency. They diminished slightly at moderate distances from Europe (Tunisia. Ethiopia) and greatly at longer distances (East Asia and West Africa). In Orientals, the frequencies ranged from 0.07 (East Indians) to 0.03 (the Chinese) and from 0.0 to 0.15 in African-Americans.... (More)

The distribution of 1.198 Malmö alleles was examined in 822 men from 16 indigenous populations and 188 women from 7 of the ethnic groups. Subjects were from several European countries, the Mediterranean, East Asia, and the USA (Anglo- and African-Americans). The frequencies of the rarer (Malmö B) allele were approximately equal across Europe, the highest frequencies (0.36) being in the French and Anglo-Americans; no population was observed with clearly the highest frequency. They diminished slightly at moderate distances from Europe (Tunisia. Ethiopia) and greatly at longer distances (East Asia and West Africa). In Orientals, the frequencies ranged from 0.07 (East Indians) to 0.03 (the Chinese) and from 0.0 to 0.15 in African-Americans. Assuming selective neutrality, the data are consistent with the European origin of the ‘B’ allele when the population was small and outward spread. © 1991 S. Karger AG, Basel.

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author
organization
publishing date
type
Contribution to journal
publication status
published
keywords
Factor IX, Malmö polymorphism, Population genetics
in
Human Heredity
volume
41
issue
6
pages
391 - 396
publisher
Karger
external identifiers
  • Scopus:0026332716
ISSN
0001-5652
DOI
10.1159/000154032
language
English
LU publication?
yes
id
6a900200-f304-4812-b9ac-7990f872f660
date added to LUP
2016-11-08 15:09:33
date last changed
2016-11-27 04:44:03
@misc{6a900200-f304-4812-b9ac-7990f872f660,
  abstract     = {<p>The distribution of 1.198 Malmö alleles was examined in 822 men from 16 indigenous populations and 188 women from 7 of the ethnic groups. Subjects were from several European countries, the Mediterranean, East Asia, and the USA (Anglo- and African-Americans). The frequencies of the rarer (Malmö B) allele were approximately equal across Europe, the highest frequencies (0.36) being in the French and Anglo-Americans; no population was observed with clearly the highest frequency. They diminished slightly at moderate distances from Europe (Tunisia. Ethiopia) and greatly at longer distances (East Asia and West Africa). In Orientals, the frequencies ranged from 0.07 (East Indians) to 0.03 (the Chinese) and from 0.0 to 0.15 in African-Americans. Assuming selective neutrality, the data are consistent with the European origin of the ‘B’ allele when the population was small and outward spread. © 1991 S. Karger AG, Basel.</p>},
  author       = {Wallmark, Anders and Kunkel, Glenna and Mouhli, Hassan and Bosco, John and Ljung, Rolf and Nilsson, Inga Marie and Graham, John B.},
  issn         = {0001-5652},
  keyword      = {Factor IX,Malmö polymorphism,Population genetics},
  language     = {eng},
  number       = {6},
  pages        = {391--396},
  publisher    = {ARRAY(0x8693978)},
  series       = {Human Heredity},
  title        = {Population genetics of the Malmö polymorphism of coagulation factor IX},
  url          = {http://dx.doi.org/10.1159/000154032},
  volume       = {41},
  year         = {1991},
}