Population genetics of the Malmö polymorphism of coagulation factor IX
Wallmark, Anders LU ; Kunkel, Glenna ; Mouhli, Hassan ; Bosco, John ; Ljung, Rolf LU
; Nilsson, Inga Marie
and Graham, John B.
(1991)
In Human Heredity
41(6).
p.391-396
- Abstract
The distribution of 1.198 Malmö alleles was examined in 822 men from 16 indigenous populations and 188 women from 7 of the ethnic groups. Subjects were from several European countries, the Mediterranean, East Asia, and the USA (Anglo- and African-Americans). The frequencies of the rarer (Malmö B) allele were approximately equal across Europe, the highest frequencies (0.36) being in the French and Anglo-Americans; no population was observed with clearly the highest frequency. They diminished slightly at moderate distances from Europe (Tunisia. Ethiopia) and greatly at longer distances (East Asia and West Africa). In Orientals, the frequencies ranged from 0.07 (East Indians) to 0.03 (the Chinese) and from 0.0 to 0.15 in African-Americans.... (More)
The distribution of 1.198 Malmö alleles was examined in 822 men from 16 indigenous populations and 188 women from 7 of the ethnic groups. Subjects were from several European countries, the Mediterranean, East Asia, and the USA (Anglo- and African-Americans). The frequencies of the rarer (Malmö B) allele were approximately equal across Europe, the highest frequencies (0.36) being in the French and Anglo-Americans; no population was observed with clearly the highest frequency. They diminished slightly at moderate distances from Europe (Tunisia. Ethiopia) and greatly at longer distances (East Asia and West Africa). In Orientals, the frequencies ranged from 0.07 (East Indians) to 0.03 (the Chinese) and from 0.0 to 0.15 in African-Americans. Assuming selective neutrality, the data are consistent with the European origin of the ‘B’ allele when the population was small and outward spread.
(Less)
- author
- Wallmark, Anders
LU
; Kunkel, Glenna
; Mouhli, Hassan
; Bosco, John
; Ljung, Rolf
LU
; Nilsson, Inga Marie
and Graham, John B.
- organization
- publishing date
- 1991
- type
- Contribution to journal
- publication status
- published
- keywords
- Factor IX, Malmö polymorphism, Population genetics
- in
- Human Heredity
- volume
- 41
- issue
- 6
- pages
- 391 - 396
- publisher
- Karger
- external identifiers
-
- pmid:1797633
- scopus:0026332716
- ISSN
- 0001-5652
- DOI
- 10.1159/000154032
- language
- English
- LU publication?
- yes
- id
- 6a900200-f304-4812-b9ac-7990f872f660
- date added to LUP
- 2016-11-08 15:09:33
- date last changed
- 2024-01-04 15:59:05
@article{6a900200-f304-4812-b9ac-7990f872f660,
abstract = {{<p>The distribution of 1.198 Malmö alleles was examined in 822 men from 16 indigenous populations and 188 women from 7 of the ethnic groups. Subjects were from several European countries, the Mediterranean, East Asia, and the USA (Anglo- and African-Americans). The frequencies of the rarer (Malmö B) allele were approximately equal across Europe, the highest frequencies (0.36) being in the French and Anglo-Americans; no population was observed with clearly the highest frequency. They diminished slightly at moderate distances from Europe (Tunisia. Ethiopia) and greatly at longer distances (East Asia and West Africa). In Orientals, the frequencies ranged from 0.07 (East Indians) to 0.03 (the Chinese) and from 0.0 to 0.15 in African-Americans. Assuming selective neutrality, the data are consistent with the European origin of the ‘B’ allele when the population was small and outward spread.</p>}},
author = {{Wallmark, Anders and Kunkel, Glenna and Mouhli, Hassan and Bosco, John and Ljung, Rolf and Nilsson, Inga Marie and Graham, John B.}},
issn = {{0001-5652}},
keywords = {{Factor IX; Malmö polymorphism; Population genetics}},
language = {{eng}},
number = {{6}},
pages = {{391--396}},
publisher = {{Karger}},
series = {{Human Heredity}},
title = {{Population genetics of the Malmö polymorphism of coagulation factor IX}},
url = {{http://dx.doi.org/10.1159/000154032}},
doi = {{10.1159/000154032}},
volume = {{41}},
year = {{1991}},
}