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What PASSes for good? : Experience-based Swedish and hypothetical British EuroQol 5-Dimensions preference sets yield markedly different point estimates and patient acceptable symptom state cut-off values in chronic arthritis patients on TNF blockade

Cooper, A; KARLSSON WALLMAN, JOHAN LU and Gülfe, A LU (2016) In Scandinavian Journal of Rheumatology
Abstract

OBJECTIVES: Health utilities derived from answers to generic health-related quality of life (HRQoL) questionnaires such as the EuroQol 5-Dimensions (EQ-5D) are often used in cost-utility analyses (CUAs) of new and expensive treatments. Different preference sets (tariffs) used in the computation of utility values and quality-adjusted life-years (QALYs) from questionnaire responses (health states) yield varying results, potentially affecting decisions of resource allocation. The objective of the present study was to compare British (UK), hypothetical, and Swedish (SE), experience-based, EQ-5D utilities using data from clinical practice.

METHOD: UK and SE EQ-5D utilities were computed in an observational cohort of patients with... (More)

OBJECTIVES: Health utilities derived from answers to generic health-related quality of life (HRQoL) questionnaires such as the EuroQol 5-Dimensions (EQ-5D) are often used in cost-utility analyses (CUAs) of new and expensive treatments. Different preference sets (tariffs) used in the computation of utility values and quality-adjusted life-years (QALYs) from questionnaire responses (health states) yield varying results, potentially affecting decisions of resource allocation. The objective of the present study was to compare British (UK), hypothetical, and Swedish (SE), experience-based, EQ-5D utilities using data from clinical practice.

METHOD: UK and SE EQ-5D utilities were computed in an observational cohort of patients with rheumatoid arthritis (RA), spondyloarthritis (SpA), and psoriatic arthritis (PsA) treated with tumour necrosis factor (TNF) blockers, comparing point estimates and patient acceptable symptom state (PASS) cut-off levels.

RESULTS: SE utilities were found to be consistently higher than UK utilities, and PASS cut-offs were essentially stable over time.

CONCLUSIONS: With higher baseline utilities, there may be less room for improvement after an intervention and thus less accumulation of QALYs in CUAs applying the SE, as opposed to the UK, EQ-5D tariff.

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author
organization
publishing date
type
Contribution to journal
publication status
epub
subject
in
Scandinavian Journal of Rheumatology
pages
4 pages
publisher
Taylor & Francis
external identifiers
  • Scopus:84961938169
ISSN
1502-7732
DOI
10.3109/03009742.2016.1143965
language
English
LU publication?
yes
id
6aa6d2d7-91f8-4d95-a337-026045709a39
date added to LUP
2016-04-18 10:54:20
date last changed
2016-10-13 05:06:28
@misc{6aa6d2d7-91f8-4d95-a337-026045709a39,
  abstract     = {<p>OBJECTIVES: Health utilities derived from answers to generic health-related quality of life (HRQoL) questionnaires such as the EuroQol 5-Dimensions (EQ-5D) are often used in cost-utility analyses (CUAs) of new and expensive treatments. Different preference sets (tariffs) used in the computation of utility values and quality-adjusted life-years (QALYs) from questionnaire responses (health states) yield varying results, potentially affecting decisions of resource allocation. The objective of the present study was to compare British (UK), hypothetical, and Swedish (SE), experience-based, EQ-5D utilities using data from clinical practice.</p><p>METHOD: UK and SE EQ-5D utilities were computed in an observational cohort of patients with rheumatoid arthritis (RA), spondyloarthritis (SpA), and psoriatic arthritis (PsA) treated with tumour necrosis factor (TNF) blockers, comparing point estimates and patient acceptable symptom state (PASS) cut-off levels.</p><p>RESULTS: SE utilities were found to be consistently higher than UK utilities, and PASS cut-offs were essentially stable over time.</p><p>CONCLUSIONS: With higher baseline utilities, there may be less room for improvement after an intervention and thus less accumulation of QALYs in CUAs applying the SE, as opposed to the UK, EQ-5D tariff.</p>},
  author       = {Cooper, A and KARLSSON WALLMAN, JOHAN and Gülfe, A},
  issn         = {1502-7732},
  language     = {eng},
  month        = {03},
  pages        = {4},
  publisher    = {ARRAY(0xa4f5d10)},
  series       = {Scandinavian Journal of Rheumatology},
  title        = {What PASSes for good? : Experience-based Swedish and hypothetical British EuroQol 5-Dimensions preference sets yield markedly different point estimates and patient acceptable symptom state cut-off values in chronic arthritis patients on TNF blockade},
  url          = {http://dx.doi.org/10.3109/03009742.2016.1143965},
  year         = {2016},
}