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Matrix metalloproteinase-8 activity is increased in type 1 diabetes children with high-risk diabetes hla and systemic inflammation

Liuba, P. LU ; Odermarsky, M.; Pussinen, P.; Sorsa, T. and Maxedius, A. LU (2012) In Cardiology in the young 22. p.115-116
Abstract
Background: Matrix metalloproteinases (MMPs) and myeloperoxidase (MPO) are colocalized to lipid-laden macrophages, and play a central role in initiation and propagation of chronic vascular diseases including atherosclerosis. Prior cross-sectional studies from our centre on children and adolescents with type 1 diabetes suggested possible propensity conferred by diabetes-risk HLA DQ2/8, particularly in an inflammatory milieu, to peripheral vascular dysfunction, an important precursor of atherosclerosis. In the same population, we aimed to assess whether this putative interplay between DQ2/8 and inflammation also reflects into increased activity of MMP and MPO. Methods: Blood pressure, inflammatory, lipid, HbA1c, cyclic guanilate monophospate... (More)
Background: Matrix metalloproteinases (MMPs) and myeloperoxidase (MPO) are colocalized to lipid-laden macrophages, and play a central role in initiation and propagation of chronic vascular diseases including atherosclerosis. Prior cross-sectional studies from our centre on children and adolescents with type 1 diabetes suggested possible propensity conferred by diabetes-risk HLA DQ2/8, particularly in an inflammatory milieu, to peripheral vascular dysfunction, an important precursor of atherosclerosis. In the same population, we aimed to assess whether this putative interplay between DQ2/8 and inflammation also reflects into increased activity of MMP and MPO. Methods: Blood pressure, inflammatory, lipid, HbA1c, cyclic guanilate monophospate (cGMP), along with degree of exposure to secondhand tobacco smoke (STS) were determined in 74 children and adolescents with type 1 diabetes at baseline and 1 year later. MMP-8 and MPO levels were measured only at the 2nd time-point. Results: In univariate regression, baseline BMI, HbA1c, CRP(log), and TC/HDL were all predictors of 1-year MMP-2 (p,.05 for all), while exposure to STS, BMI, cGMP, and TC/ HDL predicted levels of MPO (p,.05 for all). The rise in serum MMP-8 was most increased in those with both DQ2/8 and CRP .1 mg/l (p=0.01), but no such difference was noted with regard to MPO. Conclusion: In young patients with type 1 diabetes, increased activities of MMP and MPO appear to relate mainly to dyslipidemia, but inflammation, particularly in those with diabetes-risk HLA, and exposure to tobacco smoke could be important stimuli as well. (Less)
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author
organization
publishing date
type
Chapter in Book/Report/Conference proceeding
publication status
published
subject
keywords
neutrophil collagenase, lipid, hemoglobin A1c, cyclic GMP, matrix metalloproteinase, myeloperoxidase, tobacco smoke, high density lipoprotein, gelatinase A, insulin dependent diabetes mellitus, child, human, risk, diabetes mellitus, HLA system, inflammation, cardiology, Japanese (people), society, pediatric cardiology, heart surgery, exposure, adolescent, atherosclerosis, blood pressure, population, precursor, dyslipidemia, cross-sectional study, patient, serum, stimulus, vascular disease, macrophage, passive smoking
in
Cardiology in the young
volume
22
pages
2 pages
DOI
10.1017/S1047951112000509
language
English
LU publication?
yes
id
72e70fa3-c425-4fda-9838-22b53ec4bce7
date added to LUP
2016-05-04 05:24:49
date last changed
2016-05-16 11:31:05
@misc{72e70fa3-c425-4fda-9838-22b53ec4bce7,
  abstract     = {Background: Matrix metalloproteinases (MMPs) and myeloperoxidase (MPO) are colocalized to lipid-laden macrophages, and play a central role in initiation and propagation of chronic vascular diseases including atherosclerosis. Prior cross-sectional studies from our centre on children and adolescents with type 1 diabetes suggested possible propensity conferred by diabetes-risk HLA DQ2/8, particularly in an inflammatory milieu, to peripheral vascular dysfunction, an important precursor of atherosclerosis. In the same population, we aimed to assess whether this putative interplay between DQ2/8 and inflammation also reflects into increased activity of MMP and MPO. Methods: Blood pressure, inflammatory, lipid, HbA1c, cyclic guanilate monophospate (cGMP), along with degree of exposure to secondhand tobacco smoke (STS) were determined in 74 children and adolescents with type 1 diabetes at baseline and 1 year later. MMP-8 and MPO levels were measured only at the 2nd time-point. Results: In univariate regression, baseline BMI, HbA1c, CRP(log), and TC/HDL were all predictors of 1-year MMP-2 (p,.05 for all), while exposure to STS, BMI, cGMP, and TC/ HDL predicted levels of MPO (p,.05 for all). The rise in serum MMP-8 was most increased in those with both DQ2/8 and CRP .1 mg/l (p=0.01), but no such difference was noted with regard to MPO. Conclusion: In young patients with type 1 diabetes, increased activities of MMP and MPO appear to relate mainly to dyslipidemia, but inflammation, particularly in those with diabetes-risk HLA, and exposure to tobacco smoke could be important stimuli as well.},
  author       = {Liuba, P. and Odermarsky, M. and Pussinen, P. and Sorsa, T. and Maxedius, A.},
  keyword      = {neutrophil collagenase,lipid,hemoglobin A1c,cyclic GMP,matrix metalloproteinase,myeloperoxidase,tobacco smoke,high density lipoprotein,gelatinase A,insulin dependent diabetes mellitus,child,human,risk,diabetes mellitus,HLA system,inflammation,cardiology,Japanese (people),society,pediatric cardiology,heart surgery,exposure,adolescent,atherosclerosis,blood pressure,population,precursor,dyslipidemia,cross-sectional study,patient,serum,stimulus,vascular disease,macrophage,passive smoking},
  language     = {eng},
  month        = {05},
  pages        = {115--116},
  series       = {Cardiology in the young},
  title        = {Matrix metalloproteinase-8 activity is increased in type 1 diabetes children with high-risk diabetes hla and systemic inflammation},
  url          = {http://dx.doi.org/10.1017/S1047951112000509},
  volume       = {22},
  year         = {2012},
}