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Acoustic Trapping: System Design, Optimization and Applications

Evander, Mikael LU ; Johansson, Linda; Lilliehorn, Tobias; Almqvist, Monica LU ; Wallman, Lars LU ; Johansson, Stefan; Laurell, Thomas LU and Nilsson, Johan LU (2006) Micro Structure Workshop 2006 In Proceedings of the sixth Micro Structure Workshop 1. p.33-33
Abstract
Manipulation, separation and trapping of particles and cells are very important tools in today's bioanalytical and medical field. The acoustic no-contact trapping method presented at earlier MSW 2004 provides a flexible platform for performing cell and particle assays in a perfusion-based microsystem. To further develop the system microfabricated glass channels are now used, resulting in shorter fabrication times and a very inert channel material. The fluidic design has been revised to minimise the risks of leaking and hydrodynamic focusing has been incorporated to ensure a high trapping efficiency. A change of piezoelectric materials has resulted in less thermal losses in the material, higher reproducibility and shorter manufacturing... (More)
Manipulation, separation and trapping of particles and cells are very important tools in today's bioanalytical and medical field. The acoustic no-contact trapping method presented at earlier MSW 2004 provides a flexible platform for performing cell and particle assays in a perfusion-based microsystem. To further develop the system microfabricated glass channels are now used, resulting in shorter fabrication times and a very inert channel material. The fluidic design has been revised to minimise the risks of leaking and hydrodynamic focusing has been incorporated to ensure a high trapping efficiency. A change of piezoelectric materials has resulted in less thermal losses in the material, higher reproducibility and shorter manufacturing time. The trapping force was estimated by calculating the fluid force exerted on a single particle levitated in the standing wave as a reference. The temperature increase due to the losses in the transducer was measured using a fluorescent dye, indicating a maximum temperature increase of 10 degrees Celsius. Live cells have been trapped and shown to be viable while still suspended in the standing wave, thus making it possible to do on-line studies on, for example, drug response of cell populations. (Less)
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Proceedings of the sixth Micro Structure Workshop
volume
1
pages
1 pages
conference name
Micro Structure Workshop 2006
language
English
LU publication?
yes
id
8367aea9-3473-46f5-80f5-2b923f3d660e (old id 789930)
date added to LUP
2007-12-21 10:57:11
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@misc{8367aea9-3473-46f5-80f5-2b923f3d660e,
  abstract     = {Manipulation, separation and trapping of particles and cells are very important tools in today's bioanalytical and medical field. The acoustic no-contact trapping method presented at earlier MSW 2004 provides a flexible platform for performing cell and particle assays in a perfusion-based microsystem. To further develop the system microfabricated glass channels are now used, resulting in shorter fabrication times and a very inert channel material. The fluidic design has been revised to minimise the risks of leaking and hydrodynamic focusing has been incorporated to ensure a high trapping efficiency. A change of piezoelectric materials has resulted in less thermal losses in the material, higher reproducibility and shorter manufacturing time. The trapping force was estimated by calculating the fluid force exerted on a single particle levitated in the standing wave as a reference. The temperature increase due to the losses in the transducer was measured using a fluorescent dye, indicating a maximum temperature increase of 10 degrees Celsius. Live cells have been trapped and shown to be viable while still suspended in the standing wave, thus making it possible to do on-line studies on, for example, drug response of cell populations.},
  author       = {Evander, Mikael and Johansson, Linda and Lilliehorn, Tobias and Almqvist, Monica and Wallman, Lars and Johansson, Stefan and Laurell, Thomas and Nilsson, Johan},
  language     = {eng},
  pages        = {33--33},
  series       = {Proceedings of the sixth Micro Structure Workshop},
  title        = {Acoustic Trapping: System Design, Optimization and Applications},
  volume       = {1},
  year         = {2006},
}