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Cartilage proteoglycans

Aspberg, Anders LU (2016) In Cartilage: Volume 1: Physiology and Development 1. p.1-22
Abstract

Proteoglycans are key components of the cartilage extracellular matrix and essential for normal tissue function. The core protein and the glycosaminoglycan chains both contribute to function and provide different properties of the individual proteoglycans. This review is focused on the two main families of cartilage proteoglycans.The first of these is the lectican family, including aggrecan, versican, and the cartilage link protein. The aggregating proteoglycan network formed by aggrecan, link protein, and hyaluronan provides biomechanical properties that give the tissue its ability to withstand and distribute load.The second group discussed is the small leucine-rich repeat proteoglycan family, which includes decorin, biglycan, asporin,... (More)

Proteoglycans are key components of the cartilage extracellular matrix and essential for normal tissue function. The core protein and the glycosaminoglycan chains both contribute to function and provide different properties of the individual proteoglycans. This review is focused on the two main families of cartilage proteoglycans.The first of these is the lectican family, including aggrecan, versican, and the cartilage link protein. The aggregating proteoglycan network formed by aggrecan, link protein, and hyaluronan provides biomechanical properties that give the tissue its ability to withstand and distribute load.The second group discussed is the small leucine-rich repeat proteoglycan family, which includes decorin, biglycan, asporin, fibromodulin, lumican, keratocan, osteoadherin, proline-/arginine-rich end leucine-rich repeat protein, epiphycan, mimecan, opticin, chondroadherin, and chondroadherin-like. These proteoglycans bind collagens and are important regulators of cartilage extracellular matrix assembly. In addition, some of these proteoglycans bind and regulate growth factors and their receptors and regulate innate immunity through interactions with Toll-like receptors or the complement system.This review will give an overview of the structure and function of the different aggregating proteoglycans and small leucine-rich repeat proteoglycans in normal cartilage extracellular matrix.

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Please use this url to cite or link to this publication:
author
organization
publishing date
type
Chapter in Book/Report/Conference proceeding
publication status
published
subject
in
Cartilage: Volume 1: Physiology and Development
editor
Grässel, S and Aszódi, A
volume
1
pages
22 pages
publisher
Springer International Publishing
external identifiers
  • Scopus:84978194546
ISBN
9783319295688
9783319295664
DOI
10.1007/978-3-319-29568-8_1
language
English
LU publication?
yes
id
791a7fd3-cb1d-460f-b562-e6b863889773
date added to LUP
2016-07-25 13:48:01
date last changed
2016-07-28 13:47:37
@misc{791a7fd3-cb1d-460f-b562-e6b863889773,
  abstract     = {<p>Proteoglycans are key components of the cartilage extracellular matrix and essential for normal tissue function. The core protein and the glycosaminoglycan chains both contribute to function and provide different properties of the individual proteoglycans. This review is focused on the two main families of cartilage proteoglycans.The first of these is the lectican family, including aggrecan, versican, and the cartilage link protein. The aggregating proteoglycan network formed by aggrecan, link protein, and hyaluronan provides biomechanical properties that give the tissue its ability to withstand and distribute load.The second group discussed is the small leucine-rich repeat proteoglycan family, which includes decorin, biglycan, asporin, fibromodulin, lumican, keratocan, osteoadherin, proline-/arginine-rich end leucine-rich repeat protein, epiphycan, mimecan, opticin, chondroadherin, and chondroadherin-like. These proteoglycans bind collagens and are important regulators of cartilage extracellular matrix assembly. In addition, some of these proteoglycans bind and regulate growth factors and their receptors and regulate innate immunity through interactions with Toll-like receptors or the complement system.This review will give an overview of the structure and function of the different aggregating proteoglycans and small leucine-rich repeat proteoglycans in normal cartilage extracellular matrix.</p>},
  author       = {Aspberg, Anders},
  editor       = {Grässel, S and Aszódi, A},
  isbn         = {9783319295688},
  language     = {eng},
  month        = {01},
  pages        = {1--22},
  publisher    = {ARRAY(0xa743cf0)},
  series       = {Cartilage: Volume 1: Physiology and Development},
  title        = {Cartilage proteoglycans},
  url          = {http://dx.doi.org/10.1007/978-3-319-29568-8_1},
  volume       = {1},
  year         = {2016},
}