Advanced

Intraarticular injections of hyaluronan in patients with cartilage abnormalities and knee pain : A one-year double-blind, placebo-controlled study

Dahlberg, Leif LU ; Lohmander, L. Stefan LU and Ryd, Leif LU (1994) In Arthritis and Rheumatism 37(4). p.521-528
Abstract

Objective. To compare the effect of intraarticular injections of hyaluronan and placebo (vehicle, saline) in patients with knee pain on exertion and with joint cartilage abnormalities. Methods. Fifty-two patients with arthroscopically verified deep cartilage fissures and villus-like flakes in the symptomatic knee were randomly assigned to receive intraarticular injections of 2.5 ml of either hyaluronan or vehicle, weekly for 5 weeks. The effect was evaluated by both primary and secondary parameters of efficacy at 2, 4, 13, 26, and 52 weeks. Results. At the followup visits, both groups had improvement from baseline; however, there was no difference between the groups in any of the relevant variables at any time point. Conclusion. The... (More)

Objective. To compare the effect of intraarticular injections of hyaluronan and placebo (vehicle, saline) in patients with knee pain on exertion and with joint cartilage abnormalities. Methods. Fifty-two patients with arthroscopically verified deep cartilage fissures and villus-like flakes in the symptomatic knee were randomly assigned to receive intraarticular injections of 2.5 ml of either hyaluronan or vehicle, weekly for 5 weeks. The effect was evaluated by both primary and secondary parameters of efficacy at 2, 4, 13, 26, and 52 weeks. Results. At the followup visits, both groups had improvement from baseline; however, there was no difference between the groups in any of the relevant variables at any time point. Conclusion. The effects of intraarticular hyaluronan do not differ significantly from those of placebo in patients with knee pain and cartilage disease.

(Less)
Please use this url to cite or link to this publication:
author
publishing date
type
Contribution to journal
publication status
published
subject
in
Arthritis and Rheumatism
volume
37
issue
4
pages
8 pages
publisher
John Wiley & Sons
external identifiers
  • Scopus:0028299551
ISSN
0004-3591
language
English
LU publication?
no
id
80c89d34-9e7e-40d2-8041-6282db4bffa0
date added to LUP
2016-05-04 23:44:32
date last changed
2016-11-13 04:39:18
@misc{80c89d34-9e7e-40d2-8041-6282db4bffa0,
  abstract     = {<p>Objective. To compare the effect of intraarticular injections of hyaluronan and placebo (vehicle, saline) in patients with knee pain on exertion and with joint cartilage abnormalities. Methods. Fifty-two patients with arthroscopically verified deep cartilage fissures and villus-like flakes in the symptomatic knee were randomly assigned to receive intraarticular injections of 2.5 ml of either hyaluronan or vehicle, weekly for 5 weeks. The effect was evaluated by both primary and secondary parameters of efficacy at 2, 4, 13, 26, and 52 weeks. Results. At the followup visits, both groups had improvement from baseline; however, there was no difference between the groups in any of the relevant variables at any time point. Conclusion. The effects of intraarticular hyaluronan do not differ significantly from those of placebo in patients with knee pain and cartilage disease.</p>},
  author       = {Dahlberg, Leif and Lohmander, L. Stefan and Ryd, Leif},
  issn         = {0004-3591},
  language     = {eng},
  number       = {4},
  pages        = {521--528},
  publisher    = {ARRAY(0xa284da8)},
  series       = {Arthritis and Rheumatism},
  title        = {Intraarticular injections of hyaluronan in patients with cartilage abnormalities and knee pain : A one-year double-blind, placebo-controlled study},
  volume       = {37},
  year         = {1994},
}