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Pancreas volume and fat fraction in children with Type 1 diabetes

ERINGSMARK REGNÉLL, SIMON LU ; Peterson, P LU ; Trinh, L LU ; Broberg, P LU ; Leander, P LU ; Lernmark, Å LU ; Månsson, S LU and Elding Larsson, H LU (2016) In Diabetic Medicine 33(10). p.1374-1379
Abstract

AIMS: People with Type 1 diabetes have smaller pancreases than healthy individuals. Several diseases causing pancreatic atrophy are associated with pancreatic steatosis, but pancreatic fat in Type 1 diabetes has not been measured. This cross-sectional study aimed to compare pancreas size and fat fraction in children with Type 1 diabetes and controls.

METHODS: The volume and fat fraction of the pancreases of 22 children with Type 1 diabetes and 29 controls were determined using magnetic resonance imaging.

RESULTS: Pancreas volume was 27% smaller in children with diabetes (median 34.9 cm(3) ) than in controls (47.8 cm(3) ; P < 0.001). Pancreas volume correlated positively with age in controls (P = 0.033), but not in... (More)

AIMS: People with Type 1 diabetes have smaller pancreases than healthy individuals. Several diseases causing pancreatic atrophy are associated with pancreatic steatosis, but pancreatic fat in Type 1 diabetes has not been measured. This cross-sectional study aimed to compare pancreas size and fat fraction in children with Type 1 diabetes and controls.

METHODS: The volume and fat fraction of the pancreases of 22 children with Type 1 diabetes and 29 controls were determined using magnetic resonance imaging.

RESULTS: Pancreas volume was 27% smaller in children with diabetes (median 34.9 cm(3) ) than in controls (47.8 cm(3) ; P < 0.001). Pancreas volume correlated positively with age in controls (P = 0.033), but not in children with diabetes (P = 0.649). Pancreas volume did not correlate with diabetes duration, but it did correlate positively with units of insulin/kg body weight/day (P = 0.048). A linear model of pancreas volume as influenced by age, body surface area and insulin units/kg body weight/day found that insulin dosage correlated with pancreas volume after controlling for both age and body surface area (P = 0.009). Pancreatic fat fraction was not significantly different between the two groups (1.34% vs. 1.57%; P = 0.891).

CONCLUSIONS: Our findings do not indicate that pancreatic atrophy in Type 1 diabetes is associated with an increased pancreatic fat fraction, unlike some other diseases featuring reduced pancreatic volume. We speculate that our results may support the hypotheses that much of pancreatic atrophy in Type 1 diabetes occurs before the clinical onset of the disease and that exogenous insulin administration decelerates pancreatic atrophy after diabetes onset. This article is protected by copyright. All rights reserved.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Diabetic Medicine
volume
33
issue
10
pages
1374 - 1379
publisher
Wiley-Blackwell
external identifiers
  • Scopus:84963546276
ISSN
1464-5491
DOI
10.1111/dme.13115
language
English
LU publication?
yes
id
80fec8f0-f5bd-4468-bd26-a19ce8516935
date added to LUP
2016-04-13 14:04:04
date last changed
2016-10-14 14:52:21
@misc{80fec8f0-f5bd-4468-bd26-a19ce8516935,
  abstract     = {<p>AIMS: People with Type 1 diabetes have smaller pancreases than healthy individuals. Several diseases causing pancreatic atrophy are associated with pancreatic steatosis, but pancreatic fat in Type 1 diabetes has not been measured. This cross-sectional study aimed to compare pancreas size and fat fraction in children with Type 1 diabetes and controls.</p><p>METHODS: The volume and fat fraction of the pancreases of 22 children with Type 1 diabetes and 29 controls were determined using magnetic resonance imaging.</p><p>RESULTS: Pancreas volume was 27% smaller in children with diabetes (median 34.9 cm(3) ) than in controls (47.8 cm(3) ; P &lt; 0.001). Pancreas volume correlated positively with age in controls (P = 0.033), but not in children with diabetes (P = 0.649). Pancreas volume did not correlate with diabetes duration, but it did correlate positively with units of insulin/kg body weight/day (P = 0.048). A linear model of pancreas volume as influenced by age, body surface area and insulin units/kg body weight/day found that insulin dosage correlated with pancreas volume after controlling for both age and body surface area (P = 0.009). Pancreatic fat fraction was not significantly different between the two groups (1.34% vs. 1.57%; P = 0.891).</p><p>CONCLUSIONS: Our findings do not indicate that pancreatic atrophy in Type 1 diabetes is associated with an increased pancreatic fat fraction, unlike some other diseases featuring reduced pancreatic volume. We speculate that our results may support the hypotheses that much of pancreatic atrophy in Type 1 diabetes occurs before the clinical onset of the disease and that exogenous insulin administration decelerates pancreatic atrophy after diabetes onset. This article is protected by copyright. All rights reserved.</p>},
  author       = {ERINGSMARK REGNÉLL, SIMON and Peterson, P and Trinh, L and Broberg, P and Leander, P and Lernmark, Å and Månsson, S and Elding Larsson, H},
  issn         = {1464-5491},
  language     = {eng},
  month        = {03},
  number       = {10},
  pages        = {1374--1379},
  publisher    = {ARRAY(0x9dde6d0)},
  series       = {Diabetic Medicine},
  title        = {Pancreas volume and fat fraction in children with Type 1 diabetes},
  url          = {http://dx.doi.org/10.1111/dme.13115},
  volume       = {33},
  year         = {2016},
}