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Pancreatic cancer and thromboembolic disease, 150 years after Trousseau.

Ansari, David LU ; Ansari, Daniel LU ; Andersson, Roland LU and Andrén-Sandberg, Åke LU (2015) In Hepatobiliary surgery and nutrition 4(5). p.325-335
Abstract
The connection between pancreatic cancer and venous thrombosis has been discussed for almost 150 years. The exact pathophysiological mechanisms are still partly understood, but it is known that pancreatic cancer induces a prothrombotic and hypercoagulable state and genetic events involved in neoplastic transformation (e.g., KRAS, c-MET, p53), procoagulant factors [e.g., tissue factor (TF), platelet factor 4 (PF4), plasminogen activator inhibitor type 1 (PAI-1)], mucin production (e.g., through activation of P- and L-selectin) and pro-inflammatory factors [e.g., cytokines, cyclooxygenase-2 (COX-2)] may be implicated. Also pancreatitis, both acute and chronic, is associated with increased risk of venous thrombosis, but in this circumstance a... (More)
The connection between pancreatic cancer and venous thrombosis has been discussed for almost 150 years. The exact pathophysiological mechanisms are still partly understood, but it is known that pancreatic cancer induces a prothrombotic and hypercoagulable state and genetic events involved in neoplastic transformation (e.g., KRAS, c-MET, p53), procoagulant factors [e.g., tissue factor (TF), platelet factor 4 (PF4), plasminogen activator inhibitor type 1 (PAI-1)], mucin production (e.g., through activation of P- and L-selectin) and pro-inflammatory factors [e.g., cytokines, cyclooxygenase-2 (COX-2)] may be implicated. Also pancreatitis, both acute and chronic, is associated with increased risk of venous thrombosis, but in this circumstance a direct inflammatory process may be more important. This article discusses the incidence, treatment and outcome of venous thromboembolism (VTE) complicating pancreatic disease, with special emphasis on new knowledge obtained during the last fifteen years. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Hepatobiliary surgery and nutrition
volume
4
issue
5
pages
325 - 335
external identifiers
  • PMID:26605280
ISSN
2304-3881
DOI
10.3978/j.issn.2304-3881.2015.06.08
language
English
LU publication?
yes
id
7097def3-dce6-4e88-9c2a-c4e6cda95a07 (old id 8234554)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/26605280?dopt=Abstract
date added to LUP
2015-12-02 20:57:09
date last changed
2016-09-30 05:54:15
@misc{7097def3-dce6-4e88-9c2a-c4e6cda95a07,
  abstract     = {The connection between pancreatic cancer and venous thrombosis has been discussed for almost 150 years. The exact pathophysiological mechanisms are still partly understood, but it is known that pancreatic cancer induces a prothrombotic and hypercoagulable state and genetic events involved in neoplastic transformation (e.g., KRAS, c-MET, p53), procoagulant factors [e.g., tissue factor (TF), platelet factor 4 (PF4), plasminogen activator inhibitor type 1 (PAI-1)], mucin production (e.g., through activation of P- and L-selectin) and pro-inflammatory factors [e.g., cytokines, cyclooxygenase-2 (COX-2)] may be implicated. Also pancreatitis, both acute and chronic, is associated with increased risk of venous thrombosis, but in this circumstance a direct inflammatory process may be more important. This article discusses the incidence, treatment and outcome of venous thromboembolism (VTE) complicating pancreatic disease, with special emphasis on new knowledge obtained during the last fifteen years.},
  author       = {Ansari, David and Ansari, Daniel and Andersson, Roland and Andrén-Sandberg, Åke},
  issn         = {2304-3881},
  language     = {eng},
  number       = {5},
  pages        = {325--335},
  series       = {Hepatobiliary surgery and nutrition},
  title        = {Pancreatic cancer and thromboembolic disease, 150 years after Trousseau.},
  url          = {http://dx.doi.org/10.3978/j.issn.2304-3881.2015.06.08},
  volume       = {4},
  year         = {2015},
}