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Buserelin treatment to rats causes enteric neurodegeneration with moderate effects on CRF-immunoreactive neurons and Enterobacteriaceae in colon, and in acetylcholine-mediated permeability in ileum.

Sand, Elin LU ; Linninge, Caroline; Lozinska, Liudmyla; Egecioglu, Emil; Roth, Bodil LU ; Molin, Göran; Weström, Björn; Ekblad, Eva LU and Ohlsson, Bodil LU (2015) In BMC Research Notes 8(1).
Abstract
The gonadotropin-releasing hormone (GnRH) analog buserelin causes enteric neuronal loss. Acute stress or injection of corticotropin-releasing factor (CRF) affects motility, secretion, and barrier function of the gastrointestinal tract. The aim of the study was to characterize the CRF immunoreactivity in enteric neurons after buserelin treatment, and to evaluate possible effects of enteric neuropathy on gut microbiota, intestinal permeability, and stress response behavior.
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
BMC Research Notes
volume
8
issue
1
publisher
BioMed Central
external identifiers
  • PMID:26710832
  • Scopus:84955395423
ISSN
1756-0500
DOI
10.1186/s13104-015-1800-x
language
English
LU publication?
yes
id
0729119f-be87-460c-a2be-47a26630ceb6 (old id 8500358)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/26710832?dopt=Abstract
date added to LUP
2016-01-06 19:39:07
date last changed
2016-10-13 04:34:09
@misc{0729119f-be87-460c-a2be-47a26630ceb6,
  abstract     = {The gonadotropin-releasing hormone (GnRH) analog buserelin causes enteric neuronal loss. Acute stress or injection of corticotropin-releasing factor (CRF) affects motility, secretion, and barrier function of the gastrointestinal tract. The aim of the study was to characterize the CRF immunoreactivity in enteric neurons after buserelin treatment, and to evaluate possible effects of enteric neuropathy on gut microbiota, intestinal permeability, and stress response behavior.},
  author       = {Sand, Elin and Linninge, Caroline and Lozinska, Liudmyla and Egecioglu, Emil and Roth, Bodil and Molin, Göran and Weström, Björn and Ekblad, Eva and Ohlsson, Bodil},
  issn         = {1756-0500},
  language     = {eng},
  number       = {1},
  publisher    = {ARRAY(0x97c1430)},
  series       = {BMC Research Notes},
  title        = {Buserelin treatment to rats causes enteric neurodegeneration with moderate effects on CRF-immunoreactive neurons and Enterobacteriaceae in colon, and in acetylcholine-mediated permeability in ileum.},
  url          = {http://dx.doi.org/10.1186/s13104-015-1800-x},
  volume       = {8},
  year         = {2015},
}