Advanced

RIFM fragrance ingredient safety assessment, Benzyl propionate, CAS Registry Number 122-63-4.

Api, A M; Belsito, D; Bhatia, S; Bruze, Magnus LU ; Calow, P; Dagli, M L; Dekant, W; Fryer, A D; Kromidas, L and La Cava, S, et al. (2015) In Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
Abstract
The use of this material under current use conditions is supported by the existing information. This material was evaluated for genotoxicity, repeated dose toxicity, developmental toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity, skin sensitization potential, as well as, environmental safety. Repeated dose toxicity was determined to have the most conservative systemic exposure derived NO[A]EL of 14.5 mg/kg/day. A dietary 2-year chronic toxicity study conducted in rats on a suitable read across analog resulted in a MOE of 1318 while considering 78.7% absorption from skin contact and 100% from inhalation. A MOE of >100 is deemed acceptable.
Please use this url to cite or link to this publication:
author
, et al. (More)
(Less)
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
publisher
Elsevier
external identifiers
  • PMID:26702987
  • Scopus:84964679943
ISSN
1873-6351
DOI
10.1016/j.fct.2015.12.015
language
English
LU publication?
yes
id
df910352-2d0f-457d-9171-1671a9cb5421 (old id 8503664)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/26702987?dopt=Abstract
date added to LUP
2016-01-06 13:27:51
date last changed
2016-10-13 04:27:23
@misc{df910352-2d0f-457d-9171-1671a9cb5421,
  abstract     = {The use of this material under current use conditions is supported by the existing information. This material was evaluated for genotoxicity, repeated dose toxicity, developmental toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity, skin sensitization potential, as well as, environmental safety. Repeated dose toxicity was determined to have the most conservative systemic exposure derived NO[A]EL of 14.5 mg/kg/day. A dietary 2-year chronic toxicity study conducted in rats on a suitable read across analog resulted in a MOE of 1318 while considering 78.7% absorption from skin contact and 100% from inhalation. A MOE of >100 is deemed acceptable.},
  author       = {Api, A M and Belsito, D and Bhatia, S and Bruze, Magnus and Calow, P and Dagli, M L and Dekant, W and Fryer, A D and Kromidas, L and La Cava, S and Lalko, J F and Lapczynski, A and Liebler, D C and Politano, V T and Ritacco, G and Salvito, D and Schultz, T W and Shen, J and Sipes, I G and Wall, B and Wilcox, D K},
  issn         = {1873-6351},
  language     = {eng},
  month        = {12},
  publisher    = {ARRAY(0x9d22110)},
  series       = {Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association},
  title        = {RIFM fragrance ingredient safety assessment, Benzyl propionate, CAS Registry Number 122-63-4.},
  url          = {http://dx.doi.org/10.1016/j.fct.2015.12.015},
  year         = {2015},
}