Selective vulnerability in neurodegeneration: insights from clinical variants of Alzheimer's disease.
Mattsson, Niklas LU
; Schott, Jonathan M
; Hardy, John
; Turner, Martin R
and Zetterberg, Henrik
(2016)
In Journal of Neurology, Neurosurgery and Psychiatry
87.
p.1000-1004
- Abstract
- Selective vulnerability in the nervous system refers to the fact that subpopulations of neurons in different brain systems may be more or less prone to abnormal function or death in response to specific types of pathological states or injury. The concept has been used extensively as a potential way of explaining differences in degeneration patterns and the clinical presentation of different neurodegenerative diseases. Yet the increasing complexity of molecular histopathology at the cellular level in neurodegenerative disorders frequently appears at odds with phenotyping based on clinically-directed, macroscopic regional brain involvement. While cross-disease comparisons can provide insights into the differential vulnerability of networks... (More)
- Selective vulnerability in the nervous system refers to the fact that subpopulations of neurons in different brain systems may be more or less prone to abnormal function or death in response to specific types of pathological states or injury. The concept has been used extensively as a potential way of explaining differences in degeneration patterns and the clinical presentation of different neurodegenerative diseases. Yet the increasing complexity of molecular histopathology at the cellular level in neurodegenerative disorders frequently appears at odds with phenotyping based on clinically-directed, macroscopic regional brain involvement. While cross-disease comparisons can provide insights into the differential vulnerability of networks and neuronal populations, we focus here on what is known about selective vulnerability-related factors that might explain the differential phenotypic expressions of the same disease-in this case, typical and atypical forms of Alzheimer's disease. Whereas considerable progress has been made in this area, much is yet to be elucidated; further studies comparing different phenotypic variants aimed at identifying both vulnerability and resilience factors may provide valuable insights into disease pathogenesis, and suggest novel targets for therapy. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/8592617
- author
- Mattsson, Niklas
LU
; Schott, Jonathan M
; Hardy, John
; Turner, Martin R
and Zetterberg, Henrik
- organization
- publishing date
- 2016-01-08
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Journal of Neurology, Neurosurgery and Psychiatry
- volume
- 87
- pages
- 1000 - 1004
- publisher
- BMJ Publishing Group
- external identifiers
-
- pmid:26746185
- pmid:26746185
- scopus:84979791955
- wos:000383290700013
- ISSN
- 1468-330X
- DOI
- 10.1136/jnnp-2015-311321
- language
- English
- LU publication?
- yes
- id
- 04528990-ab4c-4a59-9e3c-81f60798972c (old id 8592617)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/26746185?dopt=Abstract
- date added to LUP
- 2016-04-04 09:33:41
- date last changed
- 2023-12-14 15:23:10
@article{04528990-ab4c-4a59-9e3c-81f60798972c,
abstract = {{Selective vulnerability in the nervous system refers to the fact that subpopulations of neurons in different brain systems may be more or less prone to abnormal function or death in response to specific types of pathological states or injury. The concept has been used extensively as a potential way of explaining differences in degeneration patterns and the clinical presentation of different neurodegenerative diseases. Yet the increasing complexity of molecular histopathology at the cellular level in neurodegenerative disorders frequently appears at odds with phenotyping based on clinically-directed, macroscopic regional brain involvement. While cross-disease comparisons can provide insights into the differential vulnerability of networks and neuronal populations, we focus here on what is known about selective vulnerability-related factors that might explain the differential phenotypic expressions of the same disease-in this case, typical and atypical forms of Alzheimer's disease. Whereas considerable progress has been made in this area, much is yet to be elucidated; further studies comparing different phenotypic variants aimed at identifying both vulnerability and resilience factors may provide valuable insights into disease pathogenesis, and suggest novel targets for therapy.}},
author = {{Mattsson, Niklas and Schott, Jonathan M and Hardy, John and Turner, Martin R and Zetterberg, Henrik}},
issn = {{1468-330X}},
language = {{eng}},
month = {{01}},
pages = {{1000--1004}},
publisher = {{BMJ Publishing Group}},
series = {{Journal of Neurology, Neurosurgery and Psychiatry}},
title = {{Selective vulnerability in neurodegeneration: insights from clinical variants of Alzheimer's disease.}},
url = {{http://dx.doi.org/10.1136/jnnp-2015-311321}},
doi = {{10.1136/jnnp-2015-311321}},
volume = {{87}},
year = {{2016}},
}