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The amino-terminal phosphorylation sites of C-MYC are frequently mutated in Burkitt's lymphoma lines but not in mouse plasmacytomas and rat immunocytomas

Axelson, H LU ; Henriksson, M LU ; Wang, Y LU ; Magnusson, K P LU and Klein, G (1995) In European Journal of Cancer 31A(12). p.104-2099
Abstract

We sequenced the region encoding the amino-terminal phosphorylation sites of C-MYC in the Ig/MYC translocation-carrying Burkitt lymphomas (BL), mouse plasmacytomas (MPC) and rat immunocytomas (RIC). Mutations affecting the Thr-58 codon or the immediate flanking region were found in seven of the 10 in vitro propagated BL lines. No mutations were found in any of the eight BL biopsies analysed. Germ-line sequences were also found in six in vivo and five in vitro passaged MPCs and in four in vivo transplanted RICs. These findings indicate that mutations in this region do not represent a general phenomena in Ig/MYC translocation-carrying tumours, but may confer growth advantage on BL cells under continuous in vitro propagation.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Animals, Base Sequence, Burkitt Lymphoma, Genes, myc, Humans, Leukemia, Lymphocytic, Chronic, B-Cell, Mice, Molecular Sequence Data, Phosphorylation, Plasmacytoma, Point Mutation, Polymerase Chain Reaction, Rats, Translocation, Genetic, Tumor Cells, Cultured
in
European Journal of Cancer
volume
31A
issue
12
pages
6 pages
publisher
Elsevier
external identifiers
  • Scopus:0029176520
ISSN
0959-8049
language
English
LU publication?
yes
id
87c83116-f84d-44c7-8b49-ede1e44205dd
date added to LUP
2016-08-09 09:18:39
date last changed
2016-08-10 04:00:18
@misc{87c83116-f84d-44c7-8b49-ede1e44205dd,
  abstract     = {<p>We sequenced the region encoding the amino-terminal phosphorylation sites of C-MYC in the Ig/MYC translocation-carrying Burkitt lymphomas (BL), mouse plasmacytomas (MPC) and rat immunocytomas (RIC). Mutations affecting the Thr-58 codon or the immediate flanking region were found in seven of the 10 in vitro propagated BL lines. No mutations were found in any of the eight BL biopsies analysed. Germ-line sequences were also found in six in vivo and five in vitro passaged MPCs and in four in vivo transplanted RICs. These findings indicate that mutations in this region do not represent a general phenomena in Ig/MYC translocation-carrying tumours, but may confer growth advantage on BL cells under continuous in vitro propagation.</p>},
  author       = {Axelson, H and Henriksson, M and Wang, Y and Magnusson, K P and Klein, G},
  issn         = {0959-8049},
  keyword      = {Animals,Base Sequence,Burkitt Lymphoma,Genes, myc,Humans,Leukemia, Lymphocytic, Chronic, B-Cell,Mice,Molecular Sequence Data,Phosphorylation,Plasmacytoma,Point Mutation,Polymerase Chain Reaction,Rats,Translocation, Genetic,Tumor Cells, Cultured},
  language     = {eng},
  number       = {12},
  pages        = {104--2099},
  publisher    = {ARRAY(0x82c7c58)},
  series       = {European Journal of Cancer},
  title        = {The amino-terminal phosphorylation sites of C-MYC are frequently mutated in Burkitt's lymphoma lines but not in mouse plasmacytomas and rat immunocytomas},
  volume       = {31A},
  year         = {1995},
}