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Platelet-derived S100A8/A9 and cardiovascular disease in systemic lupus erythematosus.

Lood, Christian LU ; Tydén, Helena LU ; Gullstrand, Birgitta LU ; Jönsen, Andreas LU ; Källberg, Eva LU ; Mörgelin, Matthias LU ; Kahn, Robin LU ; Gunnarsson, Iva; Leanderson, Tomas LU and Ivars, Fredrik LU , et al. (2016) In Arthritis & rheumatology (Hoboken, N.J.)
Abstract
S100A8/A9, a pro-inflammatory and pro-thrombotic protein complex, is increased in several diseases and high levels predispose to cardiovascular disease (CVD). Recently, platelet S100A8/A9 synthesis was described in mouse and humans in relation to CVD. However, the role of platelet S100A8/A9 in systemic lupus erythematosus (SLE), a disease with markedly increased cardiovascular morbidity, as well as the exact platelet distribution of the S100A8/A9 proteins has not been investigated.
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Arthritis & rheumatology (Hoboken, N.J.)
publisher
Wiley-Blackwell
external identifiers
  • PMID:26946461
  • Scopus:84979519316
ISSN
2326-5205
DOI
10.1002/art.39656
language
English
LU publication?
yes
id
858696a3-63aa-4d02-8836-1ee6358bc039 (old id 8856087)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/26946461?dopt=Abstract
date added to LUP
2016-03-15 11:57:32
date last changed
2016-10-13 04:31:28
@misc{858696a3-63aa-4d02-8836-1ee6358bc039,
  abstract     = {S100A8/A9, a pro-inflammatory and pro-thrombotic protein complex, is increased in several diseases and high levels predispose to cardiovascular disease (CVD). Recently, platelet S100A8/A9 synthesis was described in mouse and humans in relation to CVD. However, the role of platelet S100A8/A9 in systemic lupus erythematosus (SLE), a disease with markedly increased cardiovascular morbidity, as well as the exact platelet distribution of the S100A8/A9 proteins has not been investigated.},
  author       = {Lood, Christian and Tydén, Helena and Gullstrand, Birgitta and Jönsen, Andreas and Källberg, Eva and Mörgelin, Matthias and Kahn, Robin and Gunnarsson, Iva and Leanderson, Tomas and Ivars, Fredrik and Svenungsson, Elisabet and Bengtsson, Anders},
  issn         = {2326-5205},
  language     = {eng},
  month        = {03},
  publisher    = {ARRAY(0x9a54ce0)},
  series       = {Arthritis & rheumatology (Hoboken, N.J.)},
  title        = {Platelet-derived S100A8/A9 and cardiovascular disease in systemic lupus erythematosus.},
  url          = {http://dx.doi.org/10.1002/art.39656},
  year         = {2016},
}