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CD4+CD57+ T cells derived from peripheral blood do not support immunoglobulin production by B cells

Andersson, Eva LU ; Ohlin, Mats LU ; Borrebaeck, Carl A K LU and Carlsson, Roland LU (1995) In Cellular Immunology 163(2). p.245-253
Abstract

A small subpopulation of CD4+ T cells found in peripheral blood coexpresses the CD57+ marker normally found on, e.g., NK cells. It is known that this population occurs in a higher frequency in certain diseases. The same antigen has also been shown to be expressed on CD4+ T cells derived from germinal centers. The localization of this cell population to specialized lymphoid structures suggests that it may play a role in the evolution of the antibody response following antigenic stimulation in vivo. We have examined the ability of peripheral blood helper T cells coexpressing CD57 to participate in B cell activation/differentiation and evaluated their responses to polyclonal stimulation. The... (More)

A small subpopulation of CD4+ T cells found in peripheral blood coexpresses the CD57+ marker normally found on, e.g., NK cells. It is known that this population occurs in a higher frequency in certain diseases. The same antigen has also been shown to be expressed on CD4+ T cells derived from germinal centers. The localization of this cell population to specialized lymphoid structures suggests that it may play a role in the evolution of the antibody response following antigenic stimulation in vivo. We have examined the ability of peripheral blood helper T cells coexpressing CD57 to participate in B cell activation/differentiation and evaluated their responses to polyclonal stimulation. The CD4+CD57+ T cells do not express mRNA for a number of different cytokines or for the CD40 ligand after activation in vitro. Furthermore these cells do not induce differentiation of B cells into immunoglobulin-producing cells. Consequently, despite their CD4 phenotype and their ability to be activated, to express the IL-2 receptor, and to enter into the cell cycle, they do not act as T helper cells under conditions where CD4+/CD57- cells normally do so. The findings suggest that this peripheral blood helper T cell population is functionally different from regular CD4+ T cells. The basis for the lack of proper costimulatory signals for immunoglobulin production might be related to the low expression of CD28.

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author
organization
publishing date
type
Contribution to journal
publication status
published
in
Cellular Immunology
volume
163
issue
2
pages
9 pages
publisher
Elsevier
external identifiers
  • Scopus:0028998009
ISSN
0008-8749
DOI
10.1006/cimm.1995.1123
language
English
LU publication?
yes
id
8ac958c8-4be0-4551-ab8d-2579f91ef1bc
date added to LUP
2016-04-19 14:11:51
date last changed
2016-04-22 13:08:11
@misc{8ac958c8-4be0-4551-ab8d-2579f91ef1bc,
  abstract     = {<p>A small subpopulation of CD4<sup>+</sup> T cells found in peripheral blood coexpresses the CD57<sup>+</sup> marker normally found on, e.g., NK cells. It is known that this population occurs in a higher frequency in certain diseases. The same antigen has also been shown to be expressed on CD4<sup>+</sup> T cells derived from germinal centers. The localization of this cell population to specialized lymphoid structures suggests that it may play a role in the evolution of the antibody response following antigenic stimulation in vivo. We have examined the ability of peripheral blood helper T cells coexpressing CD57 to participate in B cell activation/differentiation and evaluated their responses to polyclonal stimulation. The CD4<sup>+</sup>CD57<sup>+</sup> T cells do not express mRNA for a number of different cytokines or for the CD40 ligand after activation in vitro. Furthermore these cells do not induce differentiation of B cells into immunoglobulin-producing cells. Consequently, despite their CD4 phenotype and their ability to be activated, to express the IL-2 receptor, and to enter into the cell cycle, they do not act as T helper cells under conditions where CD4<sup>+</sup>/CD57<sup>-</sup> cells normally do so. The findings suggest that this peripheral blood helper T cell population is functionally different from regular CD4<sup>+</sup> T cells. The basis for the lack of proper costimulatory signals for immunoglobulin production might be related to the low expression of CD28.</p>},
  author       = {Andersson, Eva and Ohlin, Mats and Borrebaeck, Carl A K and Carlsson, Roland},
  issn         = {0008-8749},
  language     = {eng},
  number       = {2},
  pages        = {245--253},
  publisher    = {ARRAY(0x62f3360)},
  series       = {Cellular Immunology},
  title        = {CD4+CD57+ T cells derived from peripheral blood do not support immunoglobulin production by B cells},
  url          = {http://dx.doi.org/10.1006/cimm.1995.1123},
  volume       = {163},
  year         = {1995},
}