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Gd-DTPA2--enhanced MRI of femoral knee cartilage. : A dose-response study in healthy volunteers

Tiderius, C J LU ; Olsson, L E LU ; de Verdier, H; Leander, P LU ; Ekberg, O LU and Dahlberg, L LU (2001) In Magnetic Resonance in Medicine 46(6). p.71-1067
Abstract

The negatively charged contrast agent Gd-DTPA2- distributes inversely to the cartilage fixed charged density. This enables structural cartilage examinations by contrast-enhanced MRI. In line with the development of a clinically applicable protocol for such examinations, this study describes the temporal pattern of Gd-DTPA2- distribution in femoral knee cartilage at three different doses in healthy volunteers. Nineteen volunteers (ages 21-28 years) were examined with a 1.5T MRI system. Quantitative relaxation rate measurements were made in weight-bearing central parts of femoral cartilage using sets of five turbo inversion recovery images with different inversion times. The cartilage was analyzed before and four times (1-4 h) after an... (More)

The negatively charged contrast agent Gd-DTPA2- distributes inversely to the cartilage fixed charged density. This enables structural cartilage examinations by contrast-enhanced MRI. In line with the development of a clinically applicable protocol for such examinations, this study describes the temporal pattern of Gd-DTPA2- distribution in femoral knee cartilage at three different doses in healthy volunteers. Nineteen volunteers (ages 21-28 years) were examined with a 1.5T MRI system. Quantitative relaxation rate measurements were made in weight-bearing central parts of femoral cartilage using sets of five turbo inversion recovery images with different inversion times. The cartilage was analyzed before and four times (1-4 h) after an intravenous injection of Gd-DTPA2- at single, double, and triple doses: 0.1, 0.2, and 0.3 mmol/kg body weight, respectively. The increase in R1 postcontrast was linearly dose-related at all times. The highest R1 values were registered at 2 and 3 h postcontrast, suggesting 2 h to be optimal in the clinical situation. The triple dose indicated a subtle compartmental difference in men, with higher contrast distribution medially than laterally. Results suggest that the triple dose is needed to detect minor cartilage matrix differences.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Adult, Cartilage, Articular, Contrast Media, Dose-Response Relationship, Drug, Female, Gadolinium DTPA, Humans, Knee Joint, Magnetic Resonance Imaging, Male
in
Magnetic Resonance in Medicine
volume
46
issue
6
pages
5 pages
publisher
John Wiley & Sons
external identifiers
  • Scopus:0034747168
ISSN
0740-3194
DOI
10.1002/mrm.1300
language
English
LU publication?
yes
id
8b2b4cc3-b27b-474b-9c7e-d8433232ddc3
date added to LUP
2016-08-16 12:13:35
date last changed
2016-10-13 05:12:18
@misc{8b2b4cc3-b27b-474b-9c7e-d8433232ddc3,
  abstract     = {<p>The negatively charged contrast agent Gd-DTPA2- distributes inversely to the cartilage fixed charged density. This enables structural cartilage examinations by contrast-enhanced MRI. In line with the development of a clinically applicable protocol for such examinations, this study describes the temporal pattern of Gd-DTPA2- distribution in femoral knee cartilage at three different doses in healthy volunteers. Nineteen volunteers (ages 21-28 years) were examined with a 1.5T MRI system. Quantitative relaxation rate measurements were made in weight-bearing central parts of femoral cartilage using sets of five turbo inversion recovery images with different inversion times. The cartilage was analyzed before and four times (1-4 h) after an intravenous injection of Gd-DTPA2- at single, double, and triple doses: 0.1, 0.2, and 0.3 mmol/kg body weight, respectively. The increase in R1 postcontrast was linearly dose-related at all times. The highest R1 values were registered at 2 and 3 h postcontrast, suggesting 2 h to be optimal in the clinical situation. The triple dose indicated a subtle compartmental difference in men, with higher contrast distribution medially than laterally. Results suggest that the triple dose is needed to detect minor cartilage matrix differences.</p>},
  author       = {Tiderius, C J and Olsson, L E and de Verdier, H and Leander, P and Ekberg, O and Dahlberg, L},
  issn         = {0740-3194},
  keyword      = {Adult,Cartilage, Articular,Contrast Media,Dose-Response Relationship, Drug,Female,Gadolinium DTPA,Humans,Knee Joint,Magnetic Resonance Imaging,Male},
  language     = {eng},
  number       = {6},
  pages        = {71--1067},
  publisher    = {ARRAY(0x68dd0e8)},
  series       = {Magnetic Resonance in Medicine},
  title        = {Gd-DTPA2--enhanced MRI of femoral knee cartilage. : A dose-response study in healthy volunteers},
  url          = {http://dx.doi.org/10.1002/mrm.1300},
  volume       = {46},
  year         = {2001},
}