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Prediction of pre-eclampsia combining NGAL and other biochemical markers with Doppler in the first and/or second trimester of pregnancy : A pilot study

Karampas, Grigorios A. LU ; Eleftheriades, Makarios I.; Panoulis, Konstantinos C.; Rizou, Myrto D.; Haliassos, Alexander D.; Metallinou, Dimitra K.; Mastorakos, George P. and Rizos, Demetrios A. (2016) In European Journal of Obstetrics, Gynecology and Reproductive Biology 205. p.153-157
Abstract

Objective To determine the performance of maternal characteristics, Doppler and a set of biochemical markers for pre-eclampsia (PE) screening at 11 + 0 to 13 + 6 and 20 + 1 to 25 + 6 weeks’ gestation. Study design Prospectively enrolled women at 11 + 0 to 13 + 6 and 20 + 1 to 25 + 6 weeks. Maternal characteristics, uterine artery pulsatility index (UtA-PI), ductus venosus pulsatility index (DV-PI) and serum biomarkers including pregnancy associated plasma protein – A (PAPP-A), placental growth factor (PlGF), soluble fms-like tyrosine kinase 1 (sFlt-1), s-Flt-1/PLGF ratio, asymmetric dimethylarginine (ADMA), matrix metalloproteinase 9 (MMP-9), neutrophil gelatinase-associated lipocalin (NGAL) and MMP-9/NGAL complex were recorded. Results... (More)

Objective To determine the performance of maternal characteristics, Doppler and a set of biochemical markers for pre-eclampsia (PE) screening at 11 + 0 to 13 + 6 and 20 + 1 to 25 + 6 weeks’ gestation. Study design Prospectively enrolled women at 11 + 0 to 13 + 6 and 20 + 1 to 25 + 6 weeks. Maternal characteristics, uterine artery pulsatility index (UtA-PI), ductus venosus pulsatility index (DV-PI) and serum biomarkers including pregnancy associated plasma protein – A (PAPP-A), placental growth factor (PlGF), soluble fms-like tyrosine kinase 1 (sFlt-1), s-Flt-1/PLGF ratio, asymmetric dimethylarginine (ADMA), matrix metalloproteinase 9 (MMP-9), neutrophil gelatinase-associated lipocalin (NGAL) and MMP-9/NGAL complex were recorded. Results Combination of NGAL and BMI in a logistic regression model detected 70% of PE in the first trimester (p = 0.001). Including UtA-PI and DV-PI in the model sensitivity reached 77.8% with 96.6% specificity (p = 0.004). Combination of second trimester NGAL and s-Flt-1/PLGF ratio yield specificity 100% (p = 0.001). Combination of second trimester UtA-PI with first trimester NGAL, BMI and age detected 80% of PE with specificity 91.9% (p = 0.001). Conclusion Combination of NGAL, maternal characteristics and Doppler parameters in the first and/or second trimester can detect a consistent number of PE pregnancies. NGAL is a potent new biomarker for the prediction of preeclampsia.

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author
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Biochemical makers, Ductus venosus pulsatility Index, First and/or second trimester screening, Neutrophil gelatinase-associated lipocalin, Pre-eclampsia, Uterine artery pulsatility index
in
European Journal of Obstetrics, Gynecology and Reproductive Biology
volume
205
pages
5 pages
publisher
Elsevier
external identifiers
  • Scopus:84984993532
ISSN
0301-2115
DOI
10.1016/j.ejogrb.2016.08.034
language
English
LU publication?
no
id
8d26b716-2cd4-4196-8998-572b20ac58db
date added to LUP
2016-09-29 11:46:20
date last changed
2016-09-30 03:00:02
@misc{8d26b716-2cd4-4196-8998-572b20ac58db,
  abstract     = {<p>Objective To determine the performance of maternal characteristics, Doppler and a set of biochemical markers for pre-eclampsia (PE) screening at 11 + 0 to 13 + 6 and 20 + 1 to 25 + 6 weeks’ gestation. Study design Prospectively enrolled women at 11 + 0 to 13 + 6 and 20 + 1 to 25 + 6 weeks. Maternal characteristics, uterine artery pulsatility index (UtA-PI), ductus venosus pulsatility index (DV-PI) and serum biomarkers including pregnancy associated plasma protein – A (PAPP-A), placental growth factor (PlGF), soluble fms-like tyrosine kinase 1 (sFlt-1), s-Flt-1/PLGF ratio, asymmetric dimethylarginine (ADMA), matrix metalloproteinase 9 (MMP-9), neutrophil gelatinase-associated lipocalin (NGAL) and MMP-9/NGAL complex were recorded. Results Combination of NGAL and BMI in a logistic regression model detected 70% of PE in the first trimester (p = 0.001). Including UtA-PI and DV-PI in the model sensitivity reached 77.8% with 96.6% specificity (p = 0.004). Combination of second trimester NGAL and s-Flt-1/PLGF ratio yield specificity 100% (p = 0.001). Combination of second trimester UtA-PI with first trimester NGAL, BMI and age detected 80% of PE with specificity 91.9% (p = 0.001). Conclusion Combination of NGAL, maternal characteristics and Doppler parameters in the first and/or second trimester can detect a consistent number of PE pregnancies. NGAL is a potent new biomarker for the prediction of preeclampsia.</p>},
  author       = {Karampas, Grigorios A. and Eleftheriades, Makarios I. and Panoulis, Konstantinos C. and Rizou, Myrto D. and Haliassos, Alexander D. and Metallinou, Dimitra K. and Mastorakos, George P. and Rizos, Demetrios A.},
  issn         = {0301-2115},
  keyword      = {Biochemical makers,Ductus venosus pulsatility Index,First and/or second trimester screening,Neutrophil gelatinase-associated lipocalin,Pre-eclampsia,Uterine artery pulsatility index},
  language     = {eng},
  month        = {10},
  pages        = {153--157},
  publisher    = {ARRAY(0xb45c668)},
  series       = {European Journal of Obstetrics, Gynecology and Reproductive Biology},
  title        = {Prediction of pre-eclampsia combining NGAL and other biochemical markers with Doppler in the first and/or second trimester of pregnancy : A pilot study},
  url          = {http://dx.doi.org/10.1016/j.ejogrb.2016.08.034},
  volume       = {205},
  year         = {2016},
}