Prediction of pre-eclampsia combining NGAL and other biochemical markers with Doppler in the first and/or second trimester of pregnancy : A pilot study
(2016) In European Journal of Obstetrics, Gynecology, and Reproductive Biology 205. p.153-157- Abstract
Objective To determine the performance of maternal characteristics, Doppler and a set of biochemical markers for pre-eclampsia (PE) screening at 11 + 0 to 13 + 6 and 20 + 1 to 25 + 6 weeks’ gestation. Study design Prospectively enrolled women at 11 + 0 to 13 + 6 and 20 + 1 to 25 + 6 weeks. Maternal characteristics, uterine artery pulsatility index (UtA-PI), ductus venosus pulsatility index (DV-PI) and serum biomarkers including pregnancy associated plasma protein – A (PAPP-A), placental growth factor (PlGF), soluble fms-like tyrosine kinase 1 (sFlt-1), s-Flt-1/PLGF ratio, asymmetric dimethylarginine (ADMA), matrix metalloproteinase 9 (MMP-9), neutrophil gelatinase-associated lipocalin (NGAL) and MMP-9/NGAL complex were recorded. Results... (More)
Objective To determine the performance of maternal characteristics, Doppler and a set of biochemical markers for pre-eclampsia (PE) screening at 11 + 0 to 13 + 6 and 20 + 1 to 25 + 6 weeks’ gestation. Study design Prospectively enrolled women at 11 + 0 to 13 + 6 and 20 + 1 to 25 + 6 weeks. Maternal characteristics, uterine artery pulsatility index (UtA-PI), ductus venosus pulsatility index (DV-PI) and serum biomarkers including pregnancy associated plasma protein – A (PAPP-A), placental growth factor (PlGF), soluble fms-like tyrosine kinase 1 (sFlt-1), s-Flt-1/PLGF ratio, asymmetric dimethylarginine (ADMA), matrix metalloproteinase 9 (MMP-9), neutrophil gelatinase-associated lipocalin (NGAL) and MMP-9/NGAL complex were recorded. Results Combination of NGAL and BMI in a logistic regression model detected 70% of PE in the first trimester (p = 0.001). Including UtA-PI and DV-PI in the model sensitivity reached 77.8% with 96.6% specificity (p = 0.004). Combination of second trimester NGAL and s-Flt-1/PLGF ratio yield specificity 100% (p = 0.001). Combination of second trimester UtA-PI with first trimester NGAL, BMI and age detected 80% of PE with specificity 91.9% (p = 0.001). Conclusion Combination of NGAL, maternal characteristics and Doppler parameters in the first and/or second trimester can detect a consistent number of PE pregnancies. NGAL is a potent new biomarker for the prediction of preeclampsia.
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- author
- Karampas, Grigorios A. LU ; Eleftheriades, Makarios I. ; Panoulis, Konstantinos C. ; Rizou, Myrto D. ; Haliassos, Alexander D. ; Metallinou, Dimitra K. ; Mastorakos, George P. and Rizos, Demetrios A.
- publishing date
- 2016-10-01
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Biochemical makers, Ductus venosus pulsatility Index, First and/or second trimester screening, Neutrophil gelatinase-associated lipocalin, Pre-eclampsia, Uterine artery pulsatility index
- in
- European Journal of Obstetrics, Gynecology, and Reproductive Biology
- volume
- 205
- pages
- 5 pages
- publisher
- Elsevier
- external identifiers
-
- scopus:84984993532
- pmid:27599094
- wos:000385323100028
- ISSN
- 0301-2115
- DOI
- 10.1016/j.ejogrb.2016.08.034
- language
- English
- LU publication?
- no
- id
- 8d26b716-2cd4-4196-8998-572b20ac58db
- date added to LUP
- 2016-09-29 11:46:20
- date last changed
- 2024-04-19 09:37:53
@article{8d26b716-2cd4-4196-8998-572b20ac58db,
abstract = {{<p>Objective To determine the performance of maternal characteristics, Doppler and a set of biochemical markers for pre-eclampsia (PE) screening at 11 + 0 to 13 + 6 and 20 + 1 to 25 + 6 weeks’ gestation. Study design Prospectively enrolled women at 11 + 0 to 13 + 6 and 20 + 1 to 25 + 6 weeks. Maternal characteristics, uterine artery pulsatility index (UtA-PI), ductus venosus pulsatility index (DV-PI) and serum biomarkers including pregnancy associated plasma protein – A (PAPP-A), placental growth factor (PlGF), soluble fms-like tyrosine kinase 1 (sFlt-1), s-Flt-1/PLGF ratio, asymmetric dimethylarginine (ADMA), matrix metalloproteinase 9 (MMP-9), neutrophil gelatinase-associated lipocalin (NGAL) and MMP-9/NGAL complex were recorded. Results Combination of NGAL and BMI in a logistic regression model detected 70% of PE in the first trimester (p = 0.001). Including UtA-PI and DV-PI in the model sensitivity reached 77.8% with 96.6% specificity (p = 0.004). Combination of second trimester NGAL and s-Flt-1/PLGF ratio yield specificity 100% (p = 0.001). Combination of second trimester UtA-PI with first trimester NGAL, BMI and age detected 80% of PE with specificity 91.9% (p = 0.001). Conclusion Combination of NGAL, maternal characteristics and Doppler parameters in the first and/or second trimester can detect a consistent number of PE pregnancies. NGAL is a potent new biomarker for the prediction of preeclampsia.</p>}},
author = {{Karampas, Grigorios A. and Eleftheriades, Makarios I. and Panoulis, Konstantinos C. and Rizou, Myrto D. and Haliassos, Alexander D. and Metallinou, Dimitra K. and Mastorakos, George P. and Rizos, Demetrios A.}},
issn = {{0301-2115}},
keywords = {{Biochemical makers; Ductus venosus pulsatility Index; First and/or second trimester screening; Neutrophil gelatinase-associated lipocalin; Pre-eclampsia; Uterine artery pulsatility index}},
language = {{eng}},
month = {{10}},
pages = {{153--157}},
publisher = {{Elsevier}},
series = {{European Journal of Obstetrics, Gynecology, and Reproductive Biology}},
title = {{Prediction of pre-eclampsia combining NGAL and other biochemical markers with Doppler in the first and/or second trimester of pregnancy : A pilot study}},
url = {{http://dx.doi.org/10.1016/j.ejogrb.2016.08.034}},
doi = {{10.1016/j.ejogrb.2016.08.034}},
volume = {{205}},
year = {{2016}},
}